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Author Topic: VIRxSYS announcement at AIDS Vaccine Conference  (Read 2311 times)

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Offline loneranger

  • Member
  • Posts: 16
VIRxSYS announcement at AIDS Vaccine Conference
« on: October 01, 2010, 10:35:41 AM »
Hi all

Came across this on the web this afternoon. Interesting news!


VIRxSYS Corporation Demonstrates “Functional Cure” and Survival Benefit for the simian model of HIV in Preclinical Vaccine Study

VIRxSYS Corporation, a privately held company developing vaccines

and RNA therapies for serious human diseases,today presented

results from a study of VRX1116, a simian analog for an investigational,

lentiviral-based vaccine for HIV VRX1273, at the AIDS Vaccine 2010

conference in Atlanta, GA. In this prophylactic non human primate study,

two out of five monkeys immunized with the vaccine were able to

“functionally cure,” or fully control and suppress viral replication

over time after challenge with a highly pathogenic simian

immunodeficiency virus (SIV), and have shown stable or increased CD4

counts compared to pre-challenge baselines Additionally, the death of

several monkeys in the control, unvaccinated group showed that

VRX1116-based vaccination was capable of conferring a survival benefit

following SIV infection. The vaccine was safely and repeatedly

administered and proved to be highly immunogenic with sustained immune

responses. Virological and immunological benefits, including control of

viral load and preservation of the CD4 compartment, were sustained for

as long as one year post-challenge.

"We and HIV key opinion leaders are very optimistic about these

long-term results showing viral suppression, protection of the immune

system and survival in this prophylactic study.” said Gary J. McGarrity,

PhD, Executive Vice President of Scientific and Clinical Affairs at

VIRxSYS Corporation. “In addition, the full control of SIV replication

following infection of two of our monkeys is a significant milestone in

our research to develop effective therapeutic and prophylactic vaccines

for HIV.”

VIRxSYS’ investigational VRX1273 vaccine is part of the company’s work

to create a therapeutic HIV vaccine to potentially lower HIV

transmission rates and improve the lives of millions of individuals

infected with HIV worldwide who – if they have access at all – must rely

on expensive drugs associated with serious side effects to help control

their infection. VIRxSYS is the only biotechnology company using

lentiviral vectors to develop a therapeutic HIV vaccine.

AIDS Vaccine 2010 is being held September 28 - October 1, 2010 at the

Omni Hotel in Atlanta, Georgia. The VRX1116 data was presented as

“Highly immunogenic lentiviral vaccine provides control of viral load,

preservation of the CD4 compartment, and survival advantage post-SIV



Founded in 1998, VIRxSYS is a private biotechnology company

that develops therapies for the treatment of serious

human diseases utilizing its proprietary lentiviral vector and RNA

reprogramming platforms. The Company exclusively licensed its patented

lentiviral technology from The Johns Hopkins University and acquired its

SMaRT™ RNA reprogramming technology from Intronn Inc. More information

regarding VIRxSYS can be found at www.virxsys.com.

About VIRxSYS’ HIV Vaccine Program

VIRxSYS’ lentiviral vector vaccine program is testing investigational

HIV vaccine candidates for therapeutic and/or prophylactic use. The

company’s vaccine candidates against HIV are currently being evaluated

in preclinical studies in non-human primates.

Corinth Group Communications

Russell LaMontagne, 917-744-7957

Offline tednlou2

  • Member
  • Posts: 5,731
Re: VIRxSYS announcement at AIDS Vaccine Conference
« Reply #1 on: October 06, 2010, 11:18:25 PM »
I just saw this story on the new side-bar, widget thingy.  If this has been done in monkeys, is it far-fetched that this could be achieved in humans?  With the advances in science, should we know within the decade whether we can achieve a cure or functional cure, or whether it just isn't possible?


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