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Author Topic: Vacc-4x Shows Response Seven Years after Inoculation  (Read 2811 times)

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Offline georgep77

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  • Posts: 150
Vacc-4x Shows Response Seven Years after Inoculation
« on: July 26, 2010, 02:14:23 PM »
Great news for all, hopefully soon available    :)

Researchers Present Findings Today at the XVIII International AIDS Conference, Vienna Austria
Bionor Immuno's Therapeutic HIV Vaccine Candidate Vacc-4x Targeting Conserved Domains of HIV Produce Immune Response Seven Years after Inoculation

(Vienna, Austria, 22 July 2010) Researchers at Oslo University Hospital and Bionor Pharma's subsidiary, Bionor Immuno AS today presented results from a recently conducted re-vaccination study at Norway's largest hospital, using Vacc-4x, the company's furthest advanced HIV-vaccine candidate. Twenty six of the forty HIV-patients from the 2002/03 phase IIa study were followed-up and re-vaccinated during the period January 2010-June 2010.

The data from 22 Vacc-4x primary responders was presented today in Vienna, Austria at the XVIII International AIDS Conference as a “late breaker” poster titled “Longterm proliferative CD4+ and CD8+ T cell memory detected 7 years after intradermal immunizations against short HIV Gag p24-like peptides targeting dendritic cells.” The abstract number is LB17810.

The 22 patients were studied prior to a voluntary “re-boost” of Vacc-4x. Results from the reboost of the 26 patients are expected in August / September.

"The Vacc-4x immunization technology using short peptide analogues to conserved viral protein domains has shown not only development of surprisingly long-term immunological memory T cells in these immunocompromised patients, but also that viral sequences changes during intermittent treatment interruptions were negligible," said Professor Dag Kvale, Oslo University Hospital, co-author of the study.

“Given this new data, and because Vacc-4x is comprised of 4 modified peptides that target conserved domains of the HIV p24 protein, we are especially optimistic about our ability to control HIV,” said Birger Sørensen, CEO, Bionor Immuno. “The research indicates that the vaccine is stimulating an immune response seven years after injection, which is, in itself, unprecedented in HIV. But we know we have more work to do.”

Vacc-4x has completed an international phase IIb placebo controlled, double-blind, multi-national trial in volunteers with HIV who stopped daily antiretroviral treatment. Data from this study is expected in September/October.

« Last Edit: July 26, 2010, 02:25:32 PM by georgep77 »
Come on Sangamo,  Geovax,  Bionor immuno, ...Make us happy !!!
+ 2008

Offline mecch

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  • red pill? or blue pill?
Re: Vacc-4x Shows Response Seven Years after Inoculation
« Reply #1 on: July 26, 2010, 03:37:34 PM »
nice news.
“From each, according to his ability; to each, according to his need” 1875 K Marx

Offline Inchlingblue

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  • Chad Ochocinco PETA Ad
Re: Vacc-4x Shows Response Seven Years after Inoculation
« Reply #2 on: July 26, 2010, 04:03:36 PM »
This is good news but confusing and surprising in light of their announcement that they were abandoning Vacc-4x except for its use as a CD4 booster:


So I guess it's back on track?

Offline veritas

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Re: Vacc-4x Shows Response Seven Years after Inoculation
« Reply #3 on: July 26, 2010, 04:29:44 PM »


Nice find! Oh the twists and turns of research.


Offline moskimo

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  • Posts: 31
Re: Vacc-4x Shows Response Seven Years after Inoculation
« Reply #4 on: August 09, 2010, 06:53:58 PM »
i am thrilled


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