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Author Topic: Something new on the HIV/AIDS Battle  (Read 3033 times)

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Offline Life

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  • Posts: 2,389
  • Member 2005
Something new on the HIV/AIDS Battle
« on: August 23, 2006, 07:42:46 PM »
Is this news worthy??

Major Strategic Breakthrough In Controlling The AIDS Virus Made By Montreal Researchers

23 Aug 2006



A team of researchers from the Universite de Montreal and the Centre hospitalier de l'Universite de Montreal (CHUM) have announced an important breakthrough in fighting the human immunodeficiency virus (HIV). For the first time, scientists have identified a defect in the immune response to HIV and found a way to correct the flaw. Dr. Rafick-Pierre Sekaly, an eminent researcher in cell biology, immunology, and virology, has confirmed the identification of a new therapeutic target (the PD-1 protein) that restores the function of the T cells whose role is to eliminate cells infected with the virus. This constitutes a major breakthrough, opening new prospects for the development of therapeutic strategies for controlling HIV infection. The research findings appear in today's issue of the journal Nature Medicine.

Dr. Sekaly explained that "immune system cells made non-functional by HIV can be identified by the presence of a protein that is significantly overexpressed when infected by the virus." In fact, high levels of the protein are associated with a more serious dysfunction. "The most important discovery made in this study arises from the fact that by stimulating this protein, we succeeded in preventing the virus from making immune system cells dysfunctional," he added.

The findings were simultaneously reproduced by two other laboratories - the labs headed by Dr. Bruce Walker at Harvard and Dr. Richard Koup at the NIH.

"It's a rare occurrence for three teams to work together on attacking a major problem. Up until now, the virus has been more or less invincible. By combining our efforts, we found the missing link that may enable us to defeat the virus," noted Dr. Sekaly. Discussions with partners are also underway to translate these research findings into clinical trials, which could start during the coming year.

Thanks to the joint efforts of the Universite de Montreal, the CHUM Research Centre, Genome Quebec, Genome Canada, the Canadian Institutes of Health Research (CIHR), the Canada Foundation for Innovation, the NIH, and the Fonds de la recherche en sante du Quebec (FRSQ), Quebec continues to show great leadership in the life sciences.

Paul L'Archeveque and Martin Godbout, the presidents of Genome Quebec and Genome Canada respectively, saluted the vision of the research team and the importance for Quebec and Canada of continuing to invest in genomics research. "The $14 million invested in this project certainly played a role in accelerating the researchers' work, and in helping Montreal to remain competitive on the international scene," noted the agency heads, adding that Dr. Sekaly's team was the first in the world to present the findings of this major study.

"The results of Dr. Sekaly's study represent an important step in the development of a new therapeutic approach in the fight against HIV," said Dr. Alan Bernstein, CIHR President. "This study is a compelling example of the excellence of Canadian health researchers and of Canada's contribution to the world's response to the HIV-AIDS pandemic."

"This important discovery is a powerful example of what can be achieved through partnership," added Dr. Eliot Phillipson, President and CEO of the Canada Foundation for Innovation. "Canada is proud to have researchers of Dr. Sekaly's calibre keeping our country at the forefront of the global fight against HIV-AIDS."

Dr. Mark Wainberg, Co-Director of the FRSQ-AIDS and infectious diseases Network and Co-Chair of the 16th World AIDS Conference held in Toronto last week, congratulated Dr. Sekaly and his team: "This scientific breakthrough is a giant step in the fight against AIDS. It is particularly interesting to see that some of the best research teams are working together to stop this terrible curse."

« Last Edit: August 23, 2006, 08:48:49 PM by Eric »

Offline jkinatl2

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  • Doo. Dah. Dipp-ity.
Re: Something new on the HIV/AIDS Battle??
« Reply #1 on: August 23, 2006, 07:50:57 PM »
I firmly believe we must look outside the USA for breakthroughs in science, as well as pressuring the US to utilize stem cell and genetic research.
"Many people, especially in the gay community, turn to oral sex as a safer alternative in the age of AIDS. And with HIV rates rising, people need to remember that oral sex is safer sex. It's a reasonable alternative."

-Kimberly Page-Shafer, PhD, MPH

Welcome Thread

Offline getbusyliving

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  • Posts: 33
Re: Something new on the HIV/AIDS Battle
« Reply #2 on: August 23, 2006, 08:49:54 PM »
Promising news always makes me smile.  Thanks for the smile. 
I decided it was either time to get busy living or get busy dying.

120304 diagnosed cd4 26 vl 30,000.
012305 started meds - Reyataz, Norvir, Truvada
06xx05 simply undetectable
07xx06 cd4 202 vl 94
0507 cd4 198 vl undetectable
today - feeling strong

Offline LatinAlexander

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  • Posts: 599
  • Bogota, Colombia
Re: Something new on the HIV/AIDS Battle
« Reply #3 on: August 23, 2006, 10:55:11 PM »
Thank you :)
Poz since Jul 19 2006
Initial numbers : CD4-250 VL 3500
First labs after HAART (Dec 04-2006) : CD4-432 VL-<40 (Undetectable)  cd4%=25.11%
Started HAART: Combivir+Efavirenz Aug 26 7:38 pm
Feb 08 2007 - Gradually stopping HAART cause of Myalgia. Protecting Efavirenz. Stopped Efavirenz, ahead with Combivir....
February 17 Combivir stopped.
April 3 -07 : Started ddi+3tc+efavirenz...
Gay and positive (What a lack of Identity...:) )
Looking for my Ben....

Offline RobT

  • Member
  • Posts: 319
Re: Something new on the HIV/AIDS Battle
« Reply #4 on: August 23, 2006, 11:00:28 PM »
Thankx for sharing. I always welcome good news of medical breakthrus in controlling this damned bug. I h8 it already  >:(


9/27/2005-1st test results
Viral Load >1,000,000
CD4 204
CD4%age 18
CD4/CD8 ratio .23
11/24/2005- Sustiva/Truvada
Viral Load 140
CD4 402
CD4%age .21
CD4/CD8 ratio .39
Viral Load 42
CD4 409
CD4%age .21
Viral load- undetectable
CD4 493
CD4%age .33

Next lab: 09/01/2006

Current meds: Atripla
VL: undetectable
CD4: 630

Offline Eldon

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  • Posts: 2,664
Re: Something new on the HIV/AIDS Battle
« Reply #5 on: August 23, 2006, 11:03:33 PM »
Hello Eirc, Thank you for sharing this with the family. It is always good to hear some good news concerning the breaktroughs that our researchers are working on for us in the interim.

Offline J220

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  • Posts: 587
Re: Something new on the HIV/AIDS Battle
« Reply #6 on: August 24, 2006, 12:56:40 AM »
Awesome news indeed. I read this on the Wall Street Journal, and it went into quite a bit into the technical detail. I can't remember exactly, but I think it had to do with the P1 molecule on the outside of the CD8 cells that interacted with another molecule of the virus. The results was that the CD8 cell was incapacitaded and could not seek and kill other infected cells. The best part was that they were able to use some kind of antibody to interrupt this interaction in lab tests, thereby reactivating the CD8 cell to work properly. This raises the exciting possibility that this could lead to a way to make the body fight off the infection on its own, maybe to the point of completely eliminating the infection...!
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline angels4kelly

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  • Posts: 305
  • IT JUST IS!!.....OKAY!
Re: Something new on the HIV/AIDS Battle
« Reply #7 on: August 24, 2006, 08:52:46 AM »
WOW Eric, Thanks so much!
This is great news to wake up to!!!
It all sounds so promising ;D
It seems like there's been an extra lot of breakthrough's lately! ;D




Knowing others is intelligence;
knowing yourself is true wisdom.
Mastering others is strength;
mastering yourself is true power.
Failure is not in falling down,
but the staying down

Offline Jeffreyj

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  • Posts: 1,403
Re: Something new on the HIV/AIDS Battle
« Reply #8 on: August 24, 2006, 09:01:38 AM »
Wow Thanks Eric! Sounds like a break through!
Positive since 1985


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