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Author Topic: KALETRA AND COMBIVIR  (Read 9176 times)

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Offline positvevibration

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« on: February 20, 2010, 03:42:45 pm »
My wife is HIV poz from cheating on me 8yrs ago which made me also HIV poz from her unknowingly.
However for the best interest of our kids and forgiveness we r still together after i found out the truth from her confession.
We have 3 kids and 1 on the way all NEG(DNA PROVEN)
She is now 4months Pregnant and on Kaletra and Combivir and she is always having diarrhea,its freaking me out.
Is there any other suggestions on other meds,the diarrhea is very often and for her being pregnant i am very scared.
Is this normal and if yes till when?

Offline Miss Philicia

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« Reply #1 on: February 20, 2010, 04:08:24 pm »
Yes, Kaletra can easily cause frequent diarrhea for many people.  I obtained a prescription for loperamide when I was on Kaletra and too some with every dose of Kaletra and it helped to control the diarrhea.  Loperamide is just prescription strength imodium (OTC imodium is 1 mg, loperamide is 2mg).  If your wife wishes to continue with Kaletra I would advise that she call her doctor and obtain a prescription for this.  She'll need to play around with dosing though, and it's not anything dangerous though since she's pregnant the doctor will obviously know more.  One 2mg capsule with each dose might suffice, and if it's not working just gradually increase the dose.  I was taking about 8 mg twice daily when I was on Kaletra, but most people don't have diarrhea issues as bad as I do - I've had it no matter what HIV med combo I'm on, but Kaletra is known to be one of the worst offenders.

But for now since it's a weekend maybe you should just run out and buy some OTC imodium at the drug store.

Oh, and the addition of a pancreatic enzyme also helps and increases absorption of food.  I take MS-8 Pancrecarb in addition to loperamide each day, and it's much better than just loperamide by itself.  This is also a prescription.
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Offline BT65

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« Reply #2 on: February 20, 2010, 07:06:08 pm »
Dear, I'm sending you a pm.  I don't think you know  you posted in the women's forum.

Edited to add:  In case anyone wonders who I'm talking to, it's Miss Philicia, not the OP.  But, it's alright, we won't spank her too hard, lol.
« Last Edit: February 21, 2010, 06:29:26 am by BT65 »
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Offline Brooke P.

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« Reply #3 on: February 20, 2010, 09:08:18 pm »
Just to let you know, I was on this same combo when I was pregnant and had the same side effects!  Luckily my son was negative and is healthy today and has been for 4 years! 

Good Luck to you!
Feb. 2003 -tested positive
Started Kaletra and Combivir
2/26/03  CD4=1080   VL=218,333
3/3/03    CD4=1072   VL=546,010
4/10/03  CD4=1886   VL=1901
12/23/03 CD4=1711   VL=<50
9/2009  CD4=274    VL=199,420
11/2009 CD4=574    VL=350
2/24/2010 CD4=851 VL=48

Offline TabooPrincess

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« Reply #4 on: February 23, 2010, 05:25:56 am »
Same combo for me and viread (just gave birth 2 months ago) - I suffered terribly with the loose motions all through my pregnancy. Presume that's what they've also advised for the baby to have after he/she is born? I wasn't undetectable at the birth so the baby needed to have all three.  He hated the kaletra.  Anyway I'm off the meds now and 'things' have returned back to normal.  It's not for long if she can put it up with it and it's for the baby afterall.
09/ 2008 - Seroconversion
11/2008 - Tested pos, cd4 640 vl 25400
12/2008 - cd4 794 vl 27798, 35%
03/2009 - cd4 844 vl 68846, 35%
06/2009 - cd4 476 vl 49151, 33% (pregnancy confirmed)
08/2009 - cd4 464 vl 54662, 32%
Started meds for pregnancy (Kaletra, AZT, Viread)
09/2009 - cd4 841 vl 3213, 42%
10/2009 - cd4 860 vl 1088, 41%
11/2009 - cd4 771 vl 563, 38%
12/2009 - cd4 885 vl 151 42%
Discontinued meds after baby born
02/2010 - cd4 841 vl 63781, 38%
05/2010 - cd4 1080 vl 113000, 39%
08/2010 - cd4 770 vl 109242
12/2010 - cd4 642 vl 111000, 34%
06/2011 - cd4 450 vl 222000, 33%
11/2011 - cd4 419 vl 212000, 24%
03/2012 - cd4 280 vl 118000, 26% (repeated Cd4 at 360)
05/2012 -cd4 360 vl 99,190
10/2012 Atripla, cd4 690, vl 80
12/2012 Darunavir, norvir, truvada, Cd4 680, vl u/d
07/2013 cd4 750,ud

Offline Ann

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« Reply #5 on: February 23, 2010, 07:03:14 am »
I've moved this thread out of the Women's forum as the original poster isn't a woman, even if he's asking about his wife.

I wish I had seen this thread earlier. (don't know how I missed it) It's not a great idea to recommend drugs to a pregnant woman without checking them out thoroughly. Loperimide isn't really recommended for pregnant women.

There are no adequate and well-controlled studies in pregnant women. Loperamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. source

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Offline jjmcm

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« Reply #6 on: February 23, 2010, 10:21:00 am »
Hello, I was on Kaletra for years and used fiber to eliminate the diarrhea.   I tried several but still prefer and use a product call Trufiber.  It dissolves completely in water, has no taste, and you just take it once per day before retiring.   I also use their probiotic, Theralac, which also helped me a lot.

You can buy the products here: http://store.master-supplements.com/p-18-trufiber.aspx

or here:  http://www.swansonvitamins.com/MSP002/ItemDetail?n=0


Offline newt

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« Reply #7 on: February 23, 2010, 06:06:51 pm »
Check this page for some tips, the fibre idea is good


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"The object is to be a well patient, not a good patient"


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