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Author Topic: GSK's new Integrase Inhibitor  (Read 1701 times)

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Offline Matts

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  • Posts: 269
GSK's new Integrase Inhibitor
« on: August 10, 2009, 04:16:54 PM »
A study for treatment-naives and one for salvage patients At QuestClinical:

"The data from GSK's 10 day proof of concept study was just presented at the International AIDS Meeting in South Africa. The results show a whopping 2.5 log decrease in viral load, setting a new standard of potency for an HIV drug. This integrase inhibitor appears very well tolerated and is administered once/day without the need for a PK booster.

 We'd also like to alert you that 2 further studies of this agent will be opening shortly, one for treatment-naives and one for salvage patients.

 The naive study will compare 3 arms of once/day integrase (+ 2 nucs) versus Atripla and will run for 96 weeks.

 The salvage study is premised on the observation that GSK's integrase retains laboratory activity against raltegravir-resistant virus and will be open to salvage patients who have documented or current raltegravir resistance and at least one other fully active agent to use in the background regimen. This crucial study is slated to start enrolling in September.

 Both studies are now accepting names of patients who may be interested.

 As always, please feel free to contact me with any questions. If you prefer to be removed from this email list, simply reply with the word “remove.”

With kind regards,

Dr. Jay,


415-353-0800 "



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