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Author Topic: news pro-140?  (Read 2347 times)

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Offline brazilianman

  • Member
  • Posts: 92
news pro-140?
« on: July 12, 2009, 09:08:06 AM »
no with oneself sign-on the site.

anybody knows publish pro -140?  ???
fail? ???

 ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ??? ???

Offline marius68

  • Member
  • Posts: 27
Re: news pro-140?
« Reply #1 on: November 22, 2009, 10:25:24 PM »
It's kind of old news but still relevant. Only found it now >:(



Award Description: Award Title: HIV-1 Therapy with CCR5 mAb PRO 140 Award Description: PRO 140 is a humanized monoclonal antibody that binds to CCR5, a co-receptor that is the principal molecular portal used by HIV to enter and infect immune system cells. Some strains of HIV use the CXCR4 co-receptor as a portal of entry either exclusively or alternatively to CCR5. Unlike small-molecule CCR5 antagonists, PRO 140 inhibits HIV entry at concentrations that in vitro do not appear to block CCR5's natural activity of directing the migration of immune cells towards sites of inflammation in the body. As a viral-entry inhibitor, PRO 140 is designed to treat HIV by protecting healthy cells from infection. As a monoclonal antibody, PRO 140 may have the potential for a better tolerability profile than many of the existing small-molecule therapies for HIV infection. Clinical studies have established PRO 140 as a potent antiretroviral agent with long-lived activity and an encouraging safety profile. PRO 140 represents a distinct class of CCR5 inhibitor and has the potential to provide the first long-acting, self-administered drug for HIV-1. Successful proof-of-concept studies of PRO 140 in HIV-infected individuals were conducted under parent award U19 066329. Under this ARRA supplement to the parent award, we will conduct further clinical studies with the subcutaneous formulation of PRO 140. The clinical studies are designed to optimize dosing and other conditions prior to initiating the final, pivotal phase of clinical testing. The ARRA funding will accelerate the initiation of the pivotal program and, with success, the ultimate availability to patients of this innovative approach to HIV-1 therapy.

Project Description: We are developing a subcutaneous form of PRO 140 for the treatment of HIV infection. PRO 140 represents a distinct class of CCR5 inhibitor and has the potential to provide the first long-acting, self-administered drug for HIV-1. Previously, under parent award U19 066329, we obtained results from a phase 2 study in which the subcutaneous dosage form of PRO 140 demonstrated potent and highly significant antiviral effects compared to placebo at all doses of active drug examined and was generally well tolerated. Under this ARRA supplement to parent award U19 066329, we have initiated new clinical activities with the subcutaneous form of PRO 140. Successful completion of these activities will represent an important milestone in the development of a potential new treatment option for individuals living with HIV/AIDS.

Jobs Summary: The Associate Director, Clinical Research, Biologics is responsible for Biologics projects. This position represents the Clinical Department on project teams and has direct involvement in writing, conducting, and analyzing clinical studies. This position occasionally provides formal supervision of Clinical Project Managers (CPMs) and takes a leadership role in a matrix clinical team. (Total jobs reported: 1)

Project Status: Less Than 50% Completed

This award's data was last updated on Aug. 10, 2009. Help expand these official descriptions using the wiki below.


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