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Author Topic: Where the hell is the long acting ARV?  (Read 2683 times)

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Offline newnick61

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Where the hell is the long acting ARV?
« on: June 09, 2009, 02:45:06 AM »
I remember a few years ago that there was talk about weekly or monthly ARV treatments. I see that a lot of folks are using the 123-tripla pill but even with one pill it is still an albatross tied around Nick's neck. Anyone know if there are some long lasting ARV's in the drug development pipeline?

Offline David_CA

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Re: Where the hell is the long acting ARV?
« Reply #1 on: June 09, 2009, 08:34:02 AM »
I don't have any knowledge of any long-acting ARV's.  However, once-a-day dosing (Atripla) might as well be none-a-day for me.  It's just another pill in the box.  I take meds 3 times a day for ADD, once a day for hypertension, once a day for vitamins; Atripla just blends right in with the morning pills.  I can see a long-acting ARV being great for those with compliance issues or children, though. 
Black Friday 03-03-2006
03-23-06 CD4 359 @27.4% VL 75,938
06-01-06 CD4 462 @24.3% VL > 100,000
08-15-06 CD4 388 @22.8% VL >  "
10-21-06 CD4 285 @21.9% VL >  "
  Atripla started 12-01-2006
01-08-07 CD4 429 @26.8% VL 1872!
05-08-07 CD4 478 @28.1% VL 740
08-03-07 CD4 509 @31.8% VL 370
11-06-07 CD4 570 @30.0% VL 140
02-21-08 CD4 648 @32.4% VL 600
05-19-08 CD4 695 @33.1% VL < 48 undetectable!
08-21-08 CD4 725 @34.5%
11-11-08 CD4 672 @39.5%
02-11-09 CD4 773 @36.8%
05-11-09 CD4 615 @36.2%
08-19-09 CD4 770 @38.5%
11-19-09 CD4 944 @33.7%
02-17-10 CD4 678 @39.9%  
06-03-10 CD4 768 @34.9%
09-21-10 CD4 685 @40.3%
01-10-11 CD4 908 @36.3%
05-23-11 CD4 846 @36.8% VL 80
02-13-12 CD4 911 @41.4% VL<20
You must be the change you want to see in the world.  Mahatma Gandhi

Offline next2u

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Re: Where the hell is the long acting ARV?
« Reply #2 on: June 09, 2009, 08:45:20 AM »
yeah, i remember reading about those awhile back. something that is suspended in the blood stream like nano particles or whatnot. sounded interesting. hmm, maybe someone will chime in with more useful feedback.

on aidsmeds there is an interesting article touting new research that is being pursued as well. the link is below. have a good day.


midapr07 - seroconversion
sept07 - tested poz
oct07 cd4 1013; vl 13,900; cd4% 41
feb08 cd4  694;  vl 16,160; cd4% 50.1
may08 cd4 546; vl 91,480; cd4% 32
aug08 cd4 576; vl 48,190; cd4% 40.7
dec08 cd4 559; vl 63,020; cd4% 29.4
feb09 cd4 464; vl 11,000; cd4% 26
may09 cd4 544; vl 29,710; cd4% 27.2
oct09 cd4 ...; vl 23,350; cd4% 31.6
mar10 cd4 408; vl 59,050; cd4% 31.4
aug10 cd4 328; vl 80,000; cd4% 19.3 STARTED ATRIPLA
oct10 cd4 423; vl 410 ;); cd4% 30.2
jun11 cd4 439; vl <20 ;); cd4% 33.8 <-Undetectable!
mar12 cd4 695; vl ud; cd4% 38.6
jan13 cd4 738; vl ud; cd4% 36.8
aug13 cd4 930; vl ud; cd4% 44.3
jan14 cd4 813; vl ud; cd4% 42.8
may14 cd4 783; vl *; cd4%43.5
sept14 cd4 990; vl ud; cd4% *
jun15 cd4 1152; vl ud; cd4% *
oct15 cd4 583; vl 146; cd4% 42
mar16 cd4 860

Offline Inchlingblue

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Re: Where the hell is the long acting ARV?
« Reply #3 on: June 09, 2009, 01:56:27 PM »
There is an NNRTI in development called Rilpivirine (from Tibotec) that is still in the pipeline. Aidsmeds.com says that:  The developer is experimenting with a long-lasting formulation of rilpivirine that may allow for once-monthly dosing.

The thing is it still has to be combined with two other drugs which would have to be taken every day. It's probably not within the next five years that there will be enough nanotechnology versions of drugs available that can be taken once a week or once a month, but you never know.

Who knows, there may be more of a functional cure available before that so it won't matter. ;)



And here is another link to an article called Nanotechnology May Yield Long-Lasting Meds


« Last Edit: June 09, 2009, 05:47:28 PM by Inchlingblue »

Offline Assurbanipal

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Re: Where the hell is the long acting ARV?
« Reply #4 on: June 09, 2009, 03:50:34 PM »
I have to say I'm not wildly excited about a long term ARV.  What if you happen to be among the relatively few to have side effects?  How long do you want to live with something in your body that isn't working as planned?

This is based on my personal experience with Foxamax, which my doc put me on for osteoporosis.  It's a once a week drug.  I had the very rare side effect of a big jump in blood pressure and it took about 6 weeks to come all the way back down to where it usually is. (Three weeks out it was still 30 points higher, but that was a big improvement from the first week)

There's some advantages to drugs that only last a day or two... 
5/06 VL 1M+, CD4 22, 5% , pneumonia, thrush -- O2 support 2 months, 6/06 +Kaletra/Truvada
9/06 VL 3959 CD4 297 13.5% 12/06 VL <400 CD4 350 15.2% +Pravachol
2007 VL<400, 70, 50 CD4 408-729 16.0% -19.7%
2008 VL UD CD4 468 - 538 16.7% - 24.6% Osteoporosis 11/08 doubled Pravachol, +Calcium/D
02/09 VL 100 CD4 616 23.7% 03/09 VL 130 5/09 VL 100 CD4 540 28.4% +Actonel (osteoporosis) 7/09 VL 130
8/09  new regimen Isentress/Epzicom 9/09 VL UD CD4 621 32.7% 11/09 VL UD CD4 607 26.4% swap Isentress for Prezista/Norvir 12/09 (liver and muscle issues) VL 50
2010 VL UD CD4 573-680 26.1% - 30.9% 12/10 VL 20
2011 VL UD-20 CD4 568-673 24.7%-30.6%
2012 VL UD swap Prezista/Norvir for Reyataz drop statin CD4 768-828 26.7%-30.7%
2014 VL UD - 48
2015 VL 130 Moved to Triumeq

Offline Inchlingblue

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Re: Where the hell is the long acting ARV?
« Reply #5 on: June 09, 2009, 05:50:26 PM »
Assurbanipal: You bring up a good point, although the way I understand it, these drugs would also be available in "regular" versions so it seems to me that if someone tried them that way first and established that they had few if any side effects then they could go on the long-lasting version afterward.
« Last Edit: June 09, 2009, 06:49:33 PM by Inchlingblue »

Offline mecch

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  • red pill? or blue pill?
Re: Where the hell is the long acting ARV?
« Reply #6 on: June 09, 2009, 06:20:01 PM »
I am still waiting for the scubbing bubbles that will rid my resevoirs for EVUH, darling. Wiped clean to the last brain cell. Gone, bee-otch!
“From each, according to his ability; to each, according to his need” 1875 K Marx


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