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Author Topic: Lower CD4 counts seen in new infection, than previously.  (Read 952 times)

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Offline BM

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Offline newt

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Re: Lower CD4 counts seen in new infection, than previously.
« Reply #1 on: April 21, 2009, 12:42:54 PM »
For me this is a poor article. It's the kind of article which shows why I don't like much science reporting.

The report makes no comment on the important question of statistical method and clinical significance. footnote

It's reporting a rubbish study too. I dunno how it passed peer review, especially with the title beginning "Is HIV becoming more virulent? ...".

The NATAP writeup of the study reprises a Swiss analysis looking at the same question, a considerably better study design, which concluded: nothing to say about increased virulence etc.


- matt

Footnote: the stats lesson being mean is wrong for CD4 counts, median is right, even in aggregate, +/- 3-5%  on CD4% change over 15 years is clinically irrelevant, the range of results in the 4 time periods being, ahem, possibly equal despite what your calculator says about significance.
"The object is to be a well patient, not a good patient"

Offline John2038

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Re: Lower CD4 counts seen in new infection, than previously.
« Reply #2 on: April 21, 2009, 01:42:43 PM »
I also often get upset by reading some studies:

many of them are just rubbish, it's true:

bad study design, lack of confounding factors, sample size, etc

Many of them are also contradicting each others.

I guess that many authors just try to publish, no matter what.

EDIT to add:
I often think, reading studies that these doc needs to get a statiscien, physicist or mathematics to help them to write correctly a survey, and not just a Word template.
« Last Edit: April 21, 2009, 01:46:26 PM by John2038 »


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