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Author Topic: herpes medication suppresses hiv?  (Read 2052 times)

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Offline positivmat

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herpes medication suppresses hiv?
« on: March 12, 2009, 12:55:42 PM »
Has anyone read the articles about Herpes acyclovir suppressing HIV?  Does that mean that the person already infected with herpes (2) can be newly infected with HIV and it takes longer to seroconvert?  Does it mean that it stops the HIV infection from happening to someone on acyclovir?

Has anyone had experience with acyclovir slowing down the progression of HIV?


Offline carpediem98

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Re: herpes medication suppresses hiv?
« Reply #1 on: March 12, 2009, 01:33:03 PM »
What I've read is that Herpes medicines (valtrex, acyclovir, etc) are effective against HIV in tissues that are ALSO infected with actively shedding Herpes virus.

This might actually explain the viral spike that I reference in my post below yours... I had a first outbreak of herpes at the same time as a 50-fold viral spike (i.e. from about 2000 to about 100,000) in a shortish period of time.  When I started valtrex, the viral load returned to 9000.  My doctor said that the reason for this is that HIV and herpes seem to somehow aid one another's replication.  Therefore, if we stop one, we provide some benefit to the other.

That's the working theory, anyway, from what I'm aware of.  Perhaps someone else is aware of something else...

Offline Inchlingblue

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Re: herpes medication suppresses hiv?
« Reply #2 on: March 12, 2009, 05:22:25 PM »
It's been shown that Acyclovir can lower HIV viral load, but it's possible that it may lead to some NRTI resistance with HIV meds. I asked Dr. Joel Gallant about this and he responded:

I have HIV and I'm not on meds yet. I also have herpes although I have not had an outbreak in many years. My doctor has recommended that I take suppressive therapy dosing of Valtrex (500 mg./day) saying it can help with keeping HIV viral load down (based on some studies that have shown herpes meds also fight HIV).

I have come across an article on the internet that says that doing this may lead to emergence of multi-drug resistant variants of HIV (link: http://www.sciencedaily.com/releases/2008/11/081106153636.htm)

What's your opinion about this? Thanks for your help and advice.

On Mar 5, 2009 Joel E. Gallant, M.D., M.P.H. replied:
The study mentioned above provides evidence for the first time that acyclovir (as well as Valtrex, which becomes acyclovir after administration) has modest anti-HIV activity. This may sound like a good thing, but as with entecavir (Baraclude, a hepatitis B drug), anti-HIV activity can lead to HIV drug resistance if the drug is taken by itself, without other anti-HIV medications. In the case of entecavir, the mutation selected is M184V, an important mutation that causes resistance to 3TC and FTC. The mutation that appears to be associated with acyclovir (in laboratory studies, not necessarily in humans) is V75I, a mutation that could have modest affects on susceptibility to ddI and d4T--drugs we don't use much anymore.

We've been treating people with acyclovir and related drugs for years, and haven't noticed that they have compromised the response to subsequent antiretroviral therapy. Nevertheless, this is interesting information, and perhaps should be yet another reason to ask, "Why not just treat the HIV from the beginning?"
« Last Edit: March 12, 2009, 06:53:41 PM by Inchlingblue »

Offline proud40

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Re: herpes medication suppresses hiv?
« Reply #3 on: March 31, 2009, 03:20:57 PM »
"Why not just treat the HIV from the beginning?"

Because that is not the idea. The idea is to keep HIV alive so that it remains as a means of controlling humanity, having this disease as incurable.

Offline Ann

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Re: herpes medication suppresses hiv?
« Reply #4 on: March 31, 2009, 09:27:04 PM »
"Why not just treat the HIV from the beginning?"

Because that is not the idea. The idea is to keep HIV alive so that it remains as a means of controlling humanity, having this disease as incurable.


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« Last Edit: April 01, 2009, 05:33:40 AM by Ann »
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