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Author Topic: U took any monoclonal antibody for any disease PLEASE POST experience  (Read 1600 times)

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Offline bimazek

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If U have taken any monoclonal antibody to treat any disease-- usually a cancer, or transplant rejection or auto immune, or T cell CD3 Receptor inhibitor, or Respiratory Syncytial Virus (RSV) or  lymphoma, etc see complete list below then PLEASE POST -your experiences with these meds only if you had hiv at the time, i am curious about the effect on how you felt, your body, cd4 counts up or down, did doctor say anything about them being good or bad regarding hiv infection.

I have not seen any info and am curious to hear peoples first hand experience, supposedly they are tolerable for general population

Did you have any good or bad experiences on them, were you on HAART at the time or was it before you started haart

all these drugs end in letters...... mab  for example  Abciximab,


FDA-approved therapeutic monoclonal antibody

FDA approved therapeutic antibodies

The first FDA-approved therapeutic monoclonal antibody was a murine IgG2a CD3 specific transplant rejection drug, Muromonab (OKT-3), in 1986.  Currently, twenty-one FDA-approved therapies exist, and hundreds of therapies are undergoing clinical trials. Most are concerned with immunological and oncological targets.

FDA approved monoclonal antibodies

Antibody     Brand name     Approval date     Type     Target     Approved treatment(s) 

Abciximab   ReoPro   1994     inhibition of glycoprotein IIb/IIIa   Cardiovascular disease

Adalimumab   Humira   2002    inhibition TNF-a Inflammatory diseases (auto-immune disorders)

Alemtuzumab   Campath   2001   humanized   CD52   Chronic lymphocytic leukemia

Basiliximab   Simulect   1998   chimeric   IL-2 receptor a   Transplant rejection

Bevacizumab   Avastin   2004   humanized   vascular endothelial growth factor   Colorectal cancer

Cetuximab   Erbitux   2004   chimeric   epidermal growth factor receptor   Colorectal cancer

Daclizumab   Zenapax   1997   humanized   IL-2 receptor a   Transplant rejection

Eculizumab   Soliris   2007   humanized   complement system protein C5   Inflammatory diseases including paroxysmal nocturnal hemoglobinuria

Efalizumab   Raptiva   2002   humanized   CD11a   acute myelogenous leukemia-linked to a cytotoxic agent, calicheamicin

(99mTc) Fanolesomab   NeutroSpec   2002   humanized   CD15   anti-CD15 antibodies bind selectively to neutrophils, it could be used to localize the site of an infection

Gemtuzumab   Mylotarg   2001   humanized   CD33   Inflammatory diseases (psoriasis)

Ibritumomab tiuxetan   Zevalin   2002   murine   CD20   Non-Hodgkin lymphoma (with yttrium-90 or indium-111)

Infliximab   Remicade   1998   chimeric   inhibition of TNF-a signalling   Inflammatory diseases (mostly auto-immune disorders)
111In-capromab   Erbitux   2004   chimeric   Prostate-specific antigen (PSA)   localize and stage a new or recurrent prostate cancer

Imciromab   Myoscint   1996   chimeric   myosin(in heart)   radioimmune conjugate - Indium In 111 imciromab pentetate-used for radiodiagnostic imaging of dead heart tissue
Muromonab-CD3   Orthoclone OKT3   1986   murine   T cell CD3 Receptor   Transplant rejection

Natalizumab   Tysabri   2006   humanized   T cell VLA4 receptor   Inflammatory diseases (mainly autoimmune-related multiple sclerosis therapy)

Omalizumab   Xolair   2004   humanized   immunoglobulin E (IgE)   Inflammatory diseases (mainly allergy-related asthma therapy)

Palivizumab   Synagis   1998   humanized   an epitope of the F protein of RSV   Viral infection (especially Respiratory Syncytial Virus (RSV)

Panitumumab   Vectibix   2006   human   epidermal growth factor receptor   Colorectal cancer

Ranibizumab   Lucentis   2006   humanized   vascular endothelial growth factor   Macular degeneration

Gemtuzumab ozogamicin   Mylotarg   2000   humanized   CD33   Acute myelogenous leukemia (with calicheamicin)

Rituximab   Rituxan, Mabthera   1997   chimeric   CD20   Non-Hodgkin lymphoma

Tositumomab   Bexxar   2003   murine   CD20   Non-Hodgkin lymphoma

Trastuzumab   Herceptin   1998   humanized   ErbB2   Breast cancer


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