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Author Topic: SWEET Study feedback  (Read 905 times)

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Offline Gary

  • Member
  • Posts: 37
SWEET Study feedback
« on: October 22, 2008, 04:53:38 AM »
Hi everyone,
I've not been on here in ages. I just wanted to give some feedback about a trial I took part in two years ago.  This summary of information is taken from a patient news letter that was sent to me from Gilead.

The SWEET study, conducted in the UK and Ireland was a randomised, open-label, 48 week comparative trial of Truvada and Combivir in patients with stable viral loads also taking Efavirenz.

The main aim was to look at changes in haemoglobin levels due to the fact that anaemia can have a large effect on the patients quality of life, due mostly to its association with fatigue.  Anaemia, within HIV has been linked to future deterioration of the disease independent of CD4 or VL.

The second aim of the study was to look at drug adherence, since poor adherence is a significant cause of poor viral suppression and leads to emergence of resistant viruses.  Side effects and  drug interactions are some of the factors that contribute to poor levels of drugs in the blood which can cause HIV drugs to stop working.

It is known that the use of Combivir causes short term anaemia and, in addition, long-term therapy with d4t and AZT have been associated with abnormal lipid effects (the amount of fat in the blood) and body fat distribution (lipodystrophy).

The SWEET study looked at the effects of Truvada on chronic anaemia and how that affected patients' quality of life and also its affect on lipid profiles and fat distribution.

The total length of the study was one year, with a total of 234 patients (197males and 37 females).

The two main findings of the study were:
1. Switching treatments from Combivir to Truvada when given with Efavirenz lead to improvements in haemoglobin levels and hence a reduction in the effects of anaemia.
2. Patients that switched treatments from Combivir to Truvada when given with Efavirenz, did not continure to lose limb fat and some patients regained some of their limb fat.

In January 2007, after the trial finished, I switched from Combivir to Truvada, within less than a month I felt better than I ever had done in my life, I had more energy than I knew what to do with and now almost two years on, my bum is round and full and my limbs are almost back to normal.  The effect of Combivir on my physical health was a gradual wearing down of my energy levels and slow thinning of my buttocks, limbs and face, this was starting to take its toll on my mental health, now I feel fantastic :)
Gary   ;D

Offline emeraldize

  • Member
  • Posts: 3,398
Re: SWEET Study feedback
« Reply #1 on: October 22, 2008, 06:32:13 AM »
Congratulations Gary (and Gilead)! This is a great piece of news to read first thing in the morning. May you continue to feel good, be energetic and enjoy sitting on and strutting with that re-rounded bum!

Offline Robert

  • Member
  • Posts: 2,658
Re: SWEET Study feedback
« Reply #2 on: October 22, 2008, 11:58:15 AM »
this is good news.  Thanks Gilead and GAry for participating and sharing the good news.



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