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Author Topic: "Undetectable" but testing HIV+?  (Read 3735 times)

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Offline GSOgymrat

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  • Posts: 5,122
  • HIV+ since 1993. Relentlessly gay.
"Undetectable" but testing HIV+?
« on: July 27, 2006, 05:25:36 AM »
I was wondering whether someone who had undetectable viral load due to taking HIV meds would still test positive for HIV. Does anyone know the answer to this one? Just curious.

Offline whizzer

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Re: "Undetectable" but testing HIV+?
« Reply #1 on: July 27, 2006, 07:28:29 AM »
Yes they would.  Antibodies to HIV would still be present, and would be picked up by the Elisa/Western Blot antibody tests.  Additionally, DNA PCR tests would show proviral DNA to be present, even with an undetectable RNA PCR.

Offline GSOgymrat

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  • Posts: 5,122
  • HIV+ since 1993. Relentlessly gay.
Re: "Undetectable" but testing HIV+?
« Reply #2 on: July 28, 2006, 05:08:19 AM »
Thanks for the info!

Offline lydgate

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Re: "Undetectable" but testing HIV+?
« Reply #3 on: August 03, 2006, 01:33:04 PM »
And "undetectable" doesn't mean that there is no more HIV in your body, just that the test isn't sensitive enough, beyond a certain point, to register what level of viremia is present. The two commonly used RNA PCR tests in clinical settings have detectability thresholds of 400 copies and 50 copies. (The former is generally used if the patient isn't on meds, assuming that his/her viral load will almost certainly be higher than 400; the latter is used in patients taking ART.) Super-duper-ultrasensitive assays used in research labs can now detect down to one copy.

Her finely-touched spirit had still its fine issues, though they were not widely visible. Her full nature, like that river of which Cyrus broke the strength, spent itself in channels which had no great name on the earth. But the effect of her being on those around her was incalculably diffusive: for the growing good of the world is partly dependent on unhistoric acts; and that things are not so ill with you and me as they might have been, is half owing to the number who lived faithfully a hidden life, and rest in unvisited tombs.

George Eliot, Middlemarch, final paragraph


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