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Author Topic: AGS-004 Personalized Immunotherapy seems promissing  (Read 3610 times)

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Offline Jacques

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  • Posts: 171
AGS-004 Personalized Immunotherapy seems promissing
« on: July 28, 2008, 11:48:53 PM »
"Non-personalized HIV immunotherapies are unable to raise cytotoxic T lymphocytes against HIV antigens, fail to induce T cell memory, and, most importantly, do not provide antiviral protection against the patient's own particular virus," said Jean-Pierre Routy, M.D., of McGill University Health Center and Royal Victoria Hospital, the principle investigator and sponsor of the study. "A personalized immunotherapy addresses these issues because it is able to capture private viral mutations, providing a matched, complete immune response for each individual HIV patient. This approach may overcome the weaknesses of other available therapies and therefore could result in a better chance of success for HIV treatment."

LINK  to complete article:

All I know about this study  (held  in Montreal)   is that phase I  results will be presented  in Mexico Hiv conference  next week and that  phase II is  already  recruiting.

Living positively since 1987
latest lab :july 2010
Undetectable Cd4 1080
43% on Reyataz/Norvir/Truvada

Offline bimazek

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Re: AGS-004 Personalized Immunotherapy seems promissing
« Reply #1 on: July 29, 2008, 06:14:47 PM »
this seems a bit similar to some other treatment i posted about which is good in that the persons own hiv is disabled sliced up so to speak and the parts, peptides and proteins are forming a kind of super vaccine

if you saw the TV movie  John Adams about the 2nd usa president
that was kind of the state of ART of vaccines in 1700s i posted about that on my bimazek research or somewhere else

i just looked at the press release it is 2007

a few other points

according to one of the TOP hiv experts at Univ of California -- the body everyones body is great at suppressing the virus that was in body 6 months ago  -- he said this  in a lecture --- that if the body only had to deal with the version of virus  in a few months it completely is able to deal with it, but the virus constantly changes its outer shell or its shape or something

basically this is the familiar mutation issue but on a micro level

in other words
there can be millions of mutations that occur every day to the virus

ONLY a  few actually are big enough to cause RESISTANCE to an HIV med or class of meds

so basically it is the old story of the swarm of viruses constantly mutating micro mutation everyday

every few weeks the virus escapes the immune system and the body has to build defense and this constant process is very destructive over time

so personalized may help in some way

i never understood why they dont just get all the versions together and make a vaccine out of a million different versions

there must be some UPPER limit to the versions or maybe it is like shapes of cars and models of cars and cars with dents there are infinite number of car bodies if you include the little dents that get in a car

even though there are only 300k different car bodies produced in history

that kind of thing


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