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Author Topic: Osteoporosis and HIV  (Read 1766 times)

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Offline smalltown66

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Osteoporosis and HIV
« on: July 24, 2008, 11:23:18 AM »
Does anyone have info or know where to get info on the side effects of meds that may cause Osteoporosis?
Can HIV itself cause Osteoporosis?
Is the Incidence of Hiv and Osteoporosis increase in long term survivors?

Thanks in advance for anything you may know


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Offline Miss Philicia

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Re: Osteoporosis and HIV
« Reply #1 on: July 24, 2008, 11:40:10 AM »

(there are several sections on this topic in the lesson section -- just keep clicking "next" to read it all)

Unfortunately this issue of HIV and osteoporosis in long-term survivors is QUITE new, and so you're going to find a lot of conflicting information out there.  My own view is that, like lipoatrophy, there are a lot of variables that are dependent on an individual patient's genetics, the underlying HIV infection, and certain HIV medications.  I'd be careful drawing a lot of conclusions at this time with this issue.

also see here:


On my part all I've been doing is making sure Vitamin D is one of the daily supplements I take, and limiting any glucocorticoid medication use.  The only HIV med I've had specifically mentioned by my doctor in terms of osteoporosis is Viread, but that might just be because he knows I'm on that one, and have been for years:


Viread may cause bone problems. In one clinical trial conducted by the manufacturer involving HIV-positive patients who were new to anti-HIV therapy, Viread [combined with Sustiva and Epivir] was more likely to cause decreased bone mineral density (osteopenia)—which can lead to osteoporosis—than Zerit (d4T) [combined with Sustiva and Epivir]. This can increase the risk of bone breakage, including the hip, spine, and wrist. Researchers are currently looking into the seriousness of this possible side effect. If you have a history of bone fracture or are at risk for osteopenia, your doctor may want to consider ordering bone scans on a regular basis while you are taking Viread. While it's not clear if calcium and vitamin D supplementation can help reverse this side effect, it might be a good idea if you have either osteopenia or osteoporosis and are taking Viread.
« Last Edit: July 24, 2008, 11:45:02 AM by philly267 »
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Re: Osteoporosis and HIV
« Reply #2 on: July 25, 2008, 08:49:42 PM »
Hi.   Yes, I've been told that osteoperosis can be an effect of HIV.   I was diagnosed shortly after my HIV diagnosis and am now on Alendronate (the new Fosamax generic) weekly.

Offline edfu

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Re: Osteoporosis and HIV
« Reply #3 on: July 25, 2008, 09:50:42 PM »
I've been diagnosed with osteopenia, a forerunner of osteoporosis.  It appears to be very difficult to disentangle all of the possible causes and blame only one, as is seen in the links Philly provided above.  In my case my doctor gave me four possible causes, all of which are listed as possibilities in the articles.  He couldn't/wouldn't specify which was/were applicable to my situation:

*age (I'm 65)
*long duration of HIV-positivity (more than 20 years)
*my HAART drug history (Trizivir, Epzicom, Sustiva)

Another possibility, which Philly also referred to:  genetics.  My mother, who died a year ago at 87, suffered from semi-severe osteoporosis.   
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