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Author Topic: anti-HIV-1 polyphenols isolated from Salvia yunnanensis  (Read 2290 times)

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Offline chadly

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anti-HIV-1 polyphenols isolated from Salvia yunnanensis
« on: June 11, 2008, 10:41:08 AM »
Hello all-

I'm looking to read an entire article/paper, not just the abstract portion.  Anyone happen to have an entire copy of the following journal entry?
They referenced this research, and the Salvia Root last night on NBC news.   Info, insight, and opinions appreciated as well!

Thanks to all

Three new derivatives of anti-HIV-1 polyphenols isolated from Salvia yunnanensis
Authors: Zheng-Fu Zhang a;  Zong-Gen Peng a;  Lei Gao a;  Biao Dong a;  Jian-Rui Li a;  Zhuo-Yong Li a; Hong-Shan Chen a
Affiliation:      a Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Medicinal Biotechnology, Beijing, China
DOI: 10.1080/10286020801966591
Published in: journal Journal of Asian Natural Products Research, Volume 10, Issue 5 May 2008 , pages 391 - 396

A new polyphenol, designated as salvianolic acid N, was isolated from the aqueous extracts of the roots of Salvia yunnanensis. Its chemical structure was elucidated as 3-(3,4-dihydroxylphenyl)-2-lcub(E)-3-(1,8,9-trihydroxyl-dibenzo[b,f]oxpin-3-yl)acryloxloxyrcubpropanoic acid (1) on the basis of NMR and MS spectral analyses. The new polyphenol inhibited both HIV-1 IN in vitro and also reduced HIV-1 p24 antigen in MT-4 cell lines.

During the study of anti-HIV-1 active components of the aqueous extracts of the roots of Salvia yunnanensis, three new derivatives of polyphenols, namely: methyl salvianolate A (2), ethyl salvianolate A (3) and cis-lithospermic acid (5) were isolated along with two known polyphenols, salvianolic acid A (1) and lithospermic acid (4) their structures were elucidated on the basis of NMR and MS spectral analyses. The anti-HIV-1 activities of the 5 polyphenols were tested for the inhibition of P24 antigen in HIV-1 infected MT-4 cell cultures and HIV-1 replicative enzymes in vitro.
Keywords: Salvia yunnanensis; Labiatae; Polyphenols; Anti-HIV-1 activity
« Last Edit: June 11, 2008, 11:38:57 AM by chadly »


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