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Author Topic: CROI: Kivexa and Truvada have similar efficacy and safety  (Read 2846 times)

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Offline John2038

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CROI: Kivexa and Truvada have similar efficacy and safety
« on: February 18, 2008, 01:16:04 AM »
February 14, 2008

Abacavir/3TC is comparable to tenofovir/FTC in virologic efficacy when combined with lopinavir/ritonavir through 48 weeks.

After 48 weeks of treatment, equal numbers of patients treated with Kivexa (68%) and Truvada (67%) had a viral load below 50 copies/ml. This demonstrated the virologic non-inferiority of Kivexa to Truvada.

When the investigators looked at viral suppression in patients with high baseline viral loads - above 100,000 copies/ml, they once again found that the two products had equal efficacy, with 63% of Kivexa-treated patients with a viral load above this level having an undetectable viral load at week 48 compared to 65% of those taking Truvada.

Comparable proportions of patients taking each product (Kivexa, 12%; Truvada, 11%) experienced virologic failure. This failure was more likely to involve the NRTI-associated M184V mutation in the Truvada-treated patients than in the Kivexa-treated patients.

Median CD4 cell counts after 48 weeks of treatment were 429 cells/mm3 in the Kivexa-treated patients and 370 cells/mm3 in the patients taking Truvada.


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