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Author Topic: Kaletra boosts the amount of cymbalta?  (Read 4203 times)

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Offline gregftl

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Kaletra boosts the amount of cymbalta?
« on: December 12, 2007, 02:02:03 PM »
i take kaletra and 60mg. Cymbalta in the morning and was wondering if the kaletra boosts the amount of Cymbalta in the body like it does for wellbutrin sr.

Offline pozattitude

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Re: Kaletra boosts the amount of cymbalta?
« Reply #1 on: January 02, 2008, 04:22:45 PM »
Hi Greg,

Check out the cool tools under the homepage and "check my meds" you can get all info on the drug interactions.

I take both Kaletra and Cymbalta and I have not had any problems but there is a moderate interaction between the 2 drugs

 Moderate Drug-Drug Interaction: Kaletra (lopinavir-ritonavir) and Cymbalta (duloxetine)
* The interaction is due to ritonavir which is a component of lopinavir-ritonavir
MONITOR: Coadministration with drugs that are inhibitors of CYP450 2D6 may increase the plasma concentrations of duloxetine, which is partially metabolized by the isoenzyme. The interaction is expected to occur in patients who are CYP450 2D6 extensive metabolizers (approximately 93% of Caucasians and greater than 98% of Asians and individuals of African descent). MANAGEMENT: The possibility of prolonged and/or increased pharmacologic effects of duloxetine should be considered during concomitant therapy with CYP450 2D6 inhibitors, particularly potent inhibitors such as quinidine, paroxetine, and fluoxetine.


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Offline Miss Philicia

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Re: Kaletra boosts the amount of cymbalta?
« Reply #2 on: January 02, 2008, 04:45:21 PM »
Why aren't either your HIV specialist or psychopharmacist checking for these drug interactions? 
"Iíve slept with enough men to know that Iím not gay"


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