Welcome, Guest. Please login or register.
October 17, 2017, 03:29:24 PM

Login with username, password and session length

  • Total Posts: 720813
  • Total Topics: 58461
  • Online Today: 307
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Can we create sterile CD4 ?  (Read 2256 times)

0 Members and 1 Guest are viewing this topic.

Offline John2038

  • Member
  • Posts: 1,529
  • Happiness is a journey, not a destination.
    • HIV Research News (Twitter)
Can we create sterile CD4 ?
« on: December 05, 2007, 12:49:30 PM »
I was wondering if it is possible to create sterile CD4, in others words, CD4 that can't replicate (yes, they will die) ?

But then, the idea is to get fake target for the virus so the VL progression could be potentially slowed down:
if a virus try to use such cells, it won't be able to replicate itself (so die).

In the meantime, the good CD4 can fight the virus in the blood.
This approach should not be toxic (assuming the CD4 come from our body but rendered "unfertile").

A variant could be to obtain this non fertile CD4 injecting a product in the blood.
Assuming this product is active for a given time (let say 2 days - around the lifespan of the virus), then it might potentially eliminate safely a lot of virus (without toxicities).

Well, its just a question, even if I believe some of you will found arguments to say its not possible.

« Last Edit: December 05, 2007, 01:01:55 PM by John2038 »

Offline HIVworker

  • Member
  • Posts: 918
  • HIV researcher
Re: Can we create sterile CD4 ?
« Reply #1 on: December 16, 2007, 11:48:05 PM »
So aviral sponge then - that mops up HIV and prevents other infections? But wouldn't such cells become HIV factories? To make it useful you would have to shut down all viral production and make them not replicate...back to square one. You would also need a lot of them per body. As the CD4 cells don't last very long anyhow I can't see how it would work.
NB. Any advice about HIV is given in addition to your own medical advice and not intended to replace it. You should never make clinical decisions based on what anyone says on the internet but rather check with your ID doctor first. Discussions from the internet are just that - Discussions. They may give you food for thought, but they should not direct you to do anything but fuel discussion.


Terms of Membership for these forums

© 2017 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.