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Author Topic: More risk of non-AIDS-defining cancers in HIV-positive folk despite combo  (Read 2015 times)

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Offline newt

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  • the one and original newt
Incidence of non-AIDS-defining cancers remains higher for HIV-positive individuals despite HAART (Aidsmap)

"A total of 33,420 HIV-infected [sic] patients were followed for a median of 5.1 years, with 66,840 HIV-negative individuals followed for a median of 6.4 years.

"Incidence rates of non-AIDS-defining cancers were 1260 per 100,000 person years in HIV-positive patients and 841 per 100,000 person years in HIV-negative patients. This corresponds to a 60% greater risk of developing a non-AIDS-defining cancer for HIV-positive versus HIV-negative patients (incidence rate ratio [IRR], 1.6; 95% CI: 1.5 – 1.7).

"The incidence of anal cancer (IRR 14.9; 95% CI: 10.1 – 22.1), Hodgkin's lymphoma (IRR: 4.6; 95% CI: 3.6 – 6.6), liver cancer (IRR: 2.8; 95% CI: 2.2 – 3.5), and lung cancer (IRR 2.0; 95% CI: 1.7 – 2.2) were particularly elevated in HIV-positive individuals compared to HIV-uninfected patients."

This suggests that, matching for age, gender and ethnicity, for every 1 HIV negative person who gets cancer, 1.6 HIV-positive people will do so.

Study report doesn't draw out role of coinfections in detail, particularly human papillomavirus for anal cancer and hepatitis B or C for liver cancer, which seems important.

There is a teeny bit of a problem with the HIV-negative sample being twice the size of the HIV-positive sample in the study....hmm. << this may not be important, but if it is, it would lower the relative risk somewhere more towards 1:1 rather than keep it at 1:1.6.

- matt
"The object is to be a well patient, not a good patient"


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