Welcome, Guest. Please login or register.
March 29, 2024, 11:46:51 am

Login with username, password and session length


Members
  • Total Members: 37614
  • Latest: bondann
Stats
  • Total Posts: 772955
  • Total Topics: 66311
  • Online Today: 741
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 4
Guests: 458
Total: 462

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: More risk of non-AIDS-defining cancers in HIV-positive folk despite combo  (Read 3165 times)

0 Members and 1 Guest are viewing this topic.

Offline newt

  • Member
  • Posts: 3,900
  • the one and original newt
Incidence of non-AIDS-defining cancers remains higher for HIV-positive individuals despite HAART (Aidsmap)

"A total of 33,420 HIV-infected [sic] patients were followed for a median of 5.1 years, with 66,840 HIV-negative individuals followed for a median of 6.4 years.

"Incidence rates of non-AIDS-defining cancers were 1260 per 100,000 person years in HIV-positive patients and 841 per 100,000 person years in HIV-negative patients. This corresponds to a 60% greater risk of developing a non-AIDS-defining cancer for HIV-positive versus HIV-negative patients (incidence rate ratio [IRR], 1.6; 95% CI: 1.5 – 1.7).

"The incidence of anal cancer (IRR 14.9; 95% CI: 10.1 – 22.1), Hodgkin's lymphoma (IRR: 4.6; 95% CI: 3.6 – 6.6), liver cancer (IRR: 2.8; 95% CI: 2.2 – 3.5), and lung cancer (IRR 2.0; 95% CI: 1.7 – 2.2) were particularly elevated in HIV-positive individuals compared to HIV-uninfected patients."

This suggests that, matching for age, gender and ethnicity, for every 1 HIV negative person who gets cancer, 1.6 HIV-positive people will do so.

Study report doesn't draw out role of coinfections in detail, particularly human papillomavirus for anal cancer and hepatitis B or C for liver cancer, which seems important.

There is a teeny bit of a problem with the HIV-negative sample being twice the size of the HIV-positive sample in the study....hmm. << this may not be important, but if it is, it would lower the relative risk somewhere more towards 1:1 rather than keep it at 1:1.6.

- matt
"The object is to be a well patient, not a good patient"

 


Terms of Membership for these forums
 

© 2024 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.