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Author Topic: Atripla v combivir/efavirenz study reported at IAS in Australia  (Read 4295 times)

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Offline Andy Velez

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  • Member
  • Posts: 34,126
Dear All,

FYI, I received this e mail this morning:



A three-year head-to-head study comparing AtriplaTM (efavirenz 600 mg/ emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg) components to a regimen of Combivir and efavirenz was presented today at the International AIDS Conference on HIV Pathogenesis, Treatment and Prevention in Sydney, Australia.


The study (Study 934) compares the safety and efficacy of a once-daily treatment regimen of Truvada® (emtricitabine and tenofovir disoproxil fumarate) and Sustiva® (efavirenz), to a twice-daily regimen of Combivir® (zidovudine/ lamivudine) with Sustiva once daily.  After 144 weeks of treatment, the regimen of Truvada/Sustiva was associated with significantly greater virologic suppression compared to a Combivir-based regimen, and also caused greater increases in CD4 cell counts and fewer side effects that resulted in study discontinuation.  (Truvada and Sustiva are now available in the United States as the fixed-dose tablet, Atripla.)


Full details are contained in the attached press release.  Please let me know if you would like any additional information about the study.


Thanks you,



James Loduca
Public Affairs
Gilead Sciences, Inc.
333 Lakeside Drive
Foster City, CA   94404
p: (650) 522-5908 l f: (650) 522-5953
jloduca@gilead.com l www.gilead.com
Andy Velez

Offline J220

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Re: Atripla v combivir/efavirenz study reported at IAS in Australia
« Reply #1 on: July 23, 2007, 09:35:13 am »
Excellent, thanks for posting this. J.
"Hope is my philosophy
Just needs days in which to be
Love of Life means hope for me
Born on a New Day" - John David

Offline emeraldize

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  • Posts: 3,397
Re: Atripla v combivir/efavirenz study reported at IAS in Australia
« Reply #2 on: July 23, 2007, 10:45:00 am »
Thanks Andy!

Offline vivyt

  • Member
  • Posts: 565
Re: Atripla v combivir/efavirenz study reported at IAS in Australia
« Reply #3 on: July 29, 2007, 04:27:43 pm »
I am taking Atripla and have responded very well to it. I was diagnosed 2 months ago and have been on it about that long so I can't really talk about the long term effects. I can tell you that my count has gone up and I feel MUCH better.


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