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Author Topic: I would like to contribute my idea of mixing Tre recombinase with Hyaluronic Aci  (Read 2515 times)

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Offline hahaha

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I was exciting to see the news of recombinase enzyme yesterday.  I read thru the whole news again and found that there are some thing need to be conquered:

"(AIDSmeds.com) - Scientists in Germany...  Indrani Sarkar, PhD, of the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden—remain much more reserved. Curing any infection using this technique, they caution, would first require mastering one of HIV's sneakiest tricks: its ability to hide from the immune system by laying dormant for months or years in host cells. ....

The results are promising, he says, but researchers have to make sure the slow-acting Tre enzyme works on real-world strains of HIV and figure out how to safely and precisely administer it in gene form to give it time to snip.

Ideally, Engelman writes, researchers would like to find a way to send Tre enzymes into the small number of CD4 cells that carry the virus without producing new viral particles, which allows HIV to hide from both antiretroviral drugs and the immune system"

If Tre recombinase is relatively safe for human body and the only break thru we need is to "mastering one of HIV's sneakiest tricks: its ability to hide from the immune systerm by laying dorman for months or years in host cell", then I have a following idea that may works, that is: 

Tre recombinase +  nano Hyaluronic Acid (Type III? I forget what type) + HARRT and then inject into tonsil glan and gall-bladder

Why? The reason is simple:

1. Hyaluronic Acid may be a liquid form in room temperature, after injection to human body at body temperature (37 degree), it become a "gel" and will not move to else where in the body. (If you have done plastic surgery, you will know what I mean)

2.HA is a liquid form at the beginning, so it is possible to go "deepdown" in tonsil and gall.  It is also possible to mix Tre recombinase with HA with adjustable concentration. 

3. HA will be "absorbed" by human body within 6-12 months. (That is why you need to go back to your plastic surgery every 6-12 months)  It then may "gradually" release Tre recombinase to its neighborhood -- the "reservoir" of HIV --tonsil and gall.

3.Now, if we combine HA + Tre + Harrt, and inject to the tonsil and gall,  it may  (a.) stay there and not move for over 6 months; and (b) gradually release Tre and Haart for over 6 months.  Does it then solve the problem stated above?

I am not sure if this will work since I am not a bio-tech person.  However, I wish this idea can be passed to Dr. Indrani Sarkar as a reference, and hopefully it may work.  Maybe someone here can help me to pass this concept?

If it may be done like this, it won't need 10 years......Please help.  I get my finger cross........

Aug 9, 2006 Get infected in Japan #$%^*
Oct 2006 CD4 239
Nov 2006 CD4 299 VL 60,000
Dec 1, Sustiva, Ziagan and 3TC
Jan 07, CD4 400


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