Welcome, Guest. Please login or register.
November 24, 2017, 05:05:15 PM

Login with username, password and session length

  • Total Posts: 722769
  • Total Topics: 58743
  • Online Today: 360
  • Online Ever: 1421
  • (August 13, 2016, 05:18:44 AM)
Users Online


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Am I Infected?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: PD-1 HIV reservoir may be involved new study starting in Canada Amfar  (Read 2090 times)

0 Members and 1 Guest are viewing this topic.

Offline bimazek

  • Member
  • Posts: 781
PD-1 study of HIV reservoir PD-1  may be involved new study starting in Canada Amfar

New AmfAR Research Grants HIV Treatment

this is the a major researcher in canada,  now good news pd-1 may be involved with reservior!   i am really blown away by this news... i mean who would have thought that pd-1 would be suspected or have anything to do with HIV-1 reservoir.  But this is one of the top people in field so they must have some amazing clues.. gives me hope... and i cannot believe that PD-1 is turning up associated with the viral reservoir.

New AmfAR Research Grants HIV Treatment

Elias Haddad, Ph.D.
Universite de Montreal, Quebec, Canada

Impact of PD-1 on the establishment and maintenance of the HIV-1 reservoir: The PD-1 molecule has recently been shown to be associated with the reduced ability of certain immune cells to survive and proliferate during HIV infection. Dr. Haddad will test the hypothesis that PD-1, which is present in increased amounts in immune cells specialized to fight HIV, is also involved in the establishment and/or maintenance of the HIV reservoir. This reservoir contains HIV that is resistant to both antiretroviral therapy as well as the immune system's efforts to destroy it, and so constitutes the major barrier to curing HIV infection. Discovering the role of PD-1 in establishing and maintaining the reservoir may lead to new therapies designed to eradicate the virus from the body.


i like this phrase...
new therapies designed to eradicate the virus from the body.

also interesting......  seems that maraviroc stops the immune system from getting over revved up in hiv disease...
Nancy Shulman, M.D.
Stanford University and Palo Alto VA Medical Center, Palo Alto, CA
Immunologic benefits of CCR5 inhibitor intensification: The new antiretroviral maraviroc works by blocking the cell surface protein CCR5 and thus preventing the virus from entering cells. Dr. Shulman postulates that the drug might also prevent disease by reducing the activation state of the immune system. Immune activation has been implicated in promoting HIV disease - if maraviroc can decrease HIV disease both by blocking HIV entry into cells as well as by decreasing immune activation, this could have implications for using maraviroc even in patients who might otherwise seem to be unsuitable candidates for the drug.

Offline Central79

  • Member
  • Posts: 527
That's interesting - a therapy designed to target PD-1 would kill two birds with one stone.

1. The preservation of HIV specific immune responses.
2. The reduction in viral reservoir.

I'm sure that (1) is probably more complicated that PD-1 alone, but anything that moves us down the line in terms of eradication - understanding the viral reservoir and eliminating it is a big step forwards. It'll be interesting to see where this goes.

Diagnosed January 2006
26/1/06 - 860 (22%), VL > 500,000
24/4/06 - 820 (24.6%), VL 158,000
13/7/06 - 840 (22%), VL 268,000
1/11/06 - 680 (21%), VL 93,100
29/1/07 - 1,020 (27.5%), VL 46,500
15/5/07 - 1,140 (22.8%), VL not done.
13/10/07 - 759 (23.2%), VL 170,000
6/11/07 - 630 (25%), VL 19,324
14/1/08 - 650 (21%), VL 16,192
15/4/08 - 590 (21%), VL 40, 832

Offline NYCguy

  • Member
  • Posts: 181
I wonder if Sangamo's gene-therapy designed to permanently elminate CCR5 receptors, mimicing a small percentage of the populations natural mutation, would have the same effect as maraviroc in terms of the avoidance of over-stiumulation of the immune system?
11/9/06 = #$%^&!
sometime early Dec 2006:
CD4 530 20%/VL >250,000 (&*$$%!!)
started Reyataz300mg/Norvir/Truvada 12-27-06.
1/30/07 CD4 540 30%/VL <400
4/07 CD4 600+ 33%/VL <50
6/9/07 CD4 720 37%/VL <50
10/15/07 CD4 891 (!) %? VL <50
1/2010 CD4 599 (37%) VL<50 (drop due to acute HCV)
9/2010 - looks like HCV is gone for good! And I'm finally drinking again, thank GOD
2013 - considering a switch to Stribild. but I love my Kidneys (but I hate farting all the time!)...
June 2013 - switched to Stribild.  so far so good...


Terms of Membership for these forums

© 2017 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.