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Author Topic: Videx + Zerit = nono combination (for standinbymyself)  (Read 2170 times)

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Offline newt

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Videx + Zerit = nono combination (for standinbymyself)
« on: May 01, 2007, 06:22:50 AM »
Hello standin.. welcome

You wrote:

First time posting to any forum.  well i have been poz for 10+ years and i just found out im resitant to my meds sustiva and combivir took them for 7 years now the doc gaveme prezista novir  and videx and zerit. My problem i have read some bad results from videx and zerit. I called him but he said videx and zerit are very common can anybody please give any kind of advice I am really scared about these meds .

Your doc (1) needs to be more available to discuss your meds (2) is two cents short of a dollar (I am being polite).

Videx and Zerit are both "d" drugs.  Videx is ddI and Zerit d4T.  The d refers to the chemical formulation of the medicines.  As a rule of thumb, you don't use d drugs together. Never.

Your doc should have done a resistance test before starting you on a new combo.

If Sustiva + Combivir is all you have ever taken then you have many options for a new combo. 

Sustiva is from a class of drugs called non-nucleosuide reverse transcriptase inhibitors (NNRTIs).  Resistance to one NNRTI usually means resistance to all of them.  To replace Sustiva means using a different type of drug. The alternative is a choice from several protease inhibitors (PIs).  This includes well understood (standard) ones, like Kaletra, or Reyataz boosted with a small dose of Norvir. It also includes newer ones like Prezista boosted with a small dose of Norvir.  Prezista is kinda new, recently approved, but studies show it gives very good results.

Combivir is two drugs from a class called nucleoside analogues (nukes) in one tablet.  You will probably have have several alternatives these two drugs. You really need the info from a resistance test to find out exactly which ones.  But it is more than likely (almost certain) that you can take Truvada (Viread+FTC in one once-a-day tablet).   Depending on what the resistance test says, it is even possible that you can still use Combivir if you want.  Regardless, the alternatives will be (1) less likely to cause side effects than the d drugs (2) in line with US and other treatment guidelines.

If you have taken other drugs besisdes Sustiva and Combivir, you will still have good options for a combination.  But Videx + Zerit together shouldn't be part of any of them.

Hope this helps. :-)

- matt
"The object is to be a well patient, not a good patient"

Offline standinbymyself

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Re: Videx + Zerit = nono combination (for standinbymyself)
« Reply #1 on: May 01, 2007, 06:44:07 PM »
yes it does thank you.  I have been really worried about these meds . Thank you


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