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Author Topic: Kaletra and Invirase?  (Read 2190 times)

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Offline tnboy

  • Member
  • Posts: 108
Kaletra and Invirase?
« on: April 27, 2007, 05:51:24 PM »
 Hey Guys,

    I went to my HIV Doctor today to have my 90 day lab work done. As I shared before, I continue to struggle with getting financial assistance for meds and in spite of all the efforts myself and others have made there is still no hope in site.

  My Doc even admitted today that this is the first situation he has had like this and in his words "This is DAMM Ridiculous and I don't know what to do!"

 Just before I left his office he happened to remember that he had 1 sample bottle of Kaletra and 1 of Invirase. He said it is not the ideal combo for me at this time but at least it was something to try for a month.

 Hie did tell me that given my past history of  severe side effects he was concerned that I may not be able to tolerate it because I would most likely get very sick from it.

 I am just curious if anyone here has taken these and what you guys think?

I appreciate any advice or suggestions anyone may have to offer.


Offline J.R.E.

  • Member
  • Posts: 7,539
  • Joined Dec-2003 Living positive, since 1985.
Re: Kaletra and Invirase?
« Reply #1 on: April 27, 2007, 06:08:44 PM »
Hello Mike,

Are you currently taking any antacids, or acid reflux medications? The Invarase may react with those medications, if you are taking them. It seems to me that I remember you were taking them.


Current Meds ; Viramune, Epzicom, 20mg of Atorvastatin, 25 mg of Hydrochlorothiazide.
Amlodipine Besolate 5mg-- Updated 9/24/2017

Diagnosed positive in 1985,.. In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started on  HAART on October 24th, 2003.

 As of 9/18/2017,  Viral load remains <40
CD 4 @358 /  CD4 % @ 13

 65 years young.

Offline Matty the Damned

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Re: Kaletra and Invirase?
« Reply #2 on: April 27, 2007, 06:35:11 PM »

Matty the Damned is delighted to hear from you! :-*

Darlin' I'm no expert on meds but I agree the side-effects from Kaletra combined with Invirase have the potential to be fearsome. A phrase such as "the screaming shits" will probably not do it justice. What's more, it's a bit worrying that you're being given a combo made up of protease inhibitors alone. Perhaps Newt or Gerry can shed more light on the mechanics of this.

Nevertheless, as you note, you're in a dire financial situation so probably your doctor is working from a bit of an emergency basis. I hope this is resolved for you soon.

With much fondness,


Offline tnboy

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  • Posts: 108
Re: Kaletra and Invirase?
« Reply #3 on: April 27, 2007, 06:40:36 PM »

    First let me say that In the 3 years that I have been a member of aidsmeds I can remember very few, if any, post of mine that you have not replied to and with very helpful advice. I just wanted to tell you how much I appreciate it! You are a true friend!

 Yes, you remember correctly, I do have acid reflux. For a long time I was on Nexium but now that my Medicare Part D plan does not cover Nexium I take over the counter medications daily. My doctor has told me in the past that because of the acid reflux I am very limited to the meds I can take.

 He was so desperate to come up with something that he may well have forgot. Maybe I should check with him first?

Thanks, Ray ;)

Offline tnboy

  • Member
  • Posts: 108
Re: Kaletra and Invirase?
« Reply #4 on: April 27, 2007, 06:46:55 PM »

  Great to hear from you my man!

  I think of you all the time but just have not felt up to posting so much lately. You know I Love You! :-*

  Yes, he did mention what you said and , yes, he feels it is an emergency situation and this is all he said he had to offer.
He said these are the ONLY 2 companies that will even give him samples.


Offline gerry

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  • Posts: 522
  • Joined AM Feb 2003
Re: Kaletra and Invirase?
« Reply #5 on: April 27, 2007, 09:00:17 PM »
Kaletra/Invirase has actually been used with some success in treatment-experienced individuals, prior to other newer medications becoming available, such as Fuzeon, Prezista and the other new drugs now on expanded access.  Depending on your resistance test results and previous treatment history, this might be a reasonable option.  The dose is 400mg lopinavir/100mg ritonavir (Kaletra) + 1000 mg saquinavir (Invirase) twice a day.  The studies included NRTIs in the combo, but most participants already had multiple NRTI/NNRTI resistance mutations at baseline and they still responded to the double boosted PI strategy.  It would be helpful to know your resistance test results if you have it.  If your doc can find a way to get additional samples of the meds for at least 3 months, that might be worth a try.  Also, regarding the antireflux meds, it affects atazanavir, but not invirase.
« Last Edit: April 27, 2007, 09:14:15 PM by gerry »

Offline Dragonette

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    • NotPerfectAtAll
Re: Kaletra and Invirase?
« Reply #6 on: April 29, 2007, 07:30:52 PM »
I sent you a PM.

Be well,
"If you keep one foot in yesterday, and one in tomorrow, you piss all over today". Betty Tacy

Offline Maestro

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  • Posts: 225
Re: Kaletra and Invirase?
« Reply #7 on: April 30, 2007, 12:33:16 PM »
My Uncle actually takes Kaletra/Invirase and also Ziagen.  He started Invirase in place of Viread about 8 months ago.  Nothing out of the ordinary from the switch... 

Offline tnboy

  • Member
  • Posts: 108
Re: Kaletra and Invirase?
« Reply #8 on: April 30, 2007, 05:34:03 PM »
Thanks Gerry and Maestro for the information. I appreciate it very much!

Dragonette, Thank you as well and I have responded to your PM.

Hugs to all,

Offline MSPspud

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  • Posts: 614
  • Joined Mar 2005 - Formerly UofMurbs
Re: Kaletra and Invirase?
« Reply #9 on: April 30, 2007, 06:55:17 PM »
I did a Kaletra/Invirase combo for over a year and a half and lived with it fairly well.  The GI effects in most people eventually clear (including me after a month).  The sleep issues were another thing, though I was in the minority in that department.  Regardless, I was able to function with a full time job, boyfriend and working out 4 to 5 times a week.  I think the risk of not taking them may be higher than the risk of taking them.  Best of luck!


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