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Author Topic: Atripla Taken Every Other Day Still Suppresses HIV at High Rate  (Read 3101 times)

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Offline Ptrk3

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From the April 12, 2019, edition of POZ (online) magazine:

Lede and key paragraph:

People with HIV who switch from taking Atripla (efavirenz/tenofovir disoproxil fumarate/emtricitabine) daily to taking the single-tablet antiretroviral (ARV) regimen every other day still maintained a high rate of viral suppression at one year, aidsmap reports....

...The participants were randomized evenly to stay on daily Atripla or switch to every-other-day dosing of the regimen. After 48 weeks, 97 percent of those in the daily-dosing group and 94 percent of the group assigned to take Atripla every second day had a fully suppressed viral load. The difference between these two rates was not statistically significant, meaning it could have been driven by chance.

###

Link to story:

https://www.poz.com/article/atripla-taken-every-day-still-suppresses-hiv-high-rate

Source story links:

https://www.aidsmap.com/page/3471710/

https://www.ncbi.nlm.nih.gov/pubmed/30702517
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Offline Jim Allen

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Re: Atripla Taken Every Other Day Still Suppresses HIV at High Rate
« Reply #1 on: April 12, 2019, 02:55:25 pm »
Interesting to see that side effect rates were similar.
Quote
Regardless of their study group, the participants exhibited comparable rates of cholesterol or triglyceride changes and neuropsychological symptoms, such as sleep quality, anxiety and dizziness. Efavirenz’s association with such neuropsychiatric symptoms has contributed to the drug’s loss of status as a recommended component of first-line treatment in the United States.


All in all reminds me of FOTO study. (5 days on, 2 days off)

https://www.poz.com/article/hiv-efavirenz-intermittent-16959-8019

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Offline Jmarksto

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Re: Atripla Taken Every Other Day Still Suppresses HIV at High Rate
« Reply #2 on: April 21, 2019, 04:54:44 pm »
This seems like it would be a pretty big deal - it would essentially cut the cost of medications in 1/2.  Also, 1/2 the drugs through the body has to be easier on the body in the long run. 


Its interesting that the research is on Atripla, which is no longer a first line therapy.  The cynic in me thinks this kind of research on first line drugs isn't done or is scuttled -- 1/2 the revenue for a few very big drug companies would drive stock prices down pretty quick.
03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45% VL 25
02/25/14 CD4   792/37% VL UD
07/09/14 CD4 1004/39% VL UD
11/03/14 CD4   711/34% VL UD
03/13/15 CD4   833/36% VL UD
04/??/15 Truvada & Tivicay
06/01/15 CD4 1100/50% VL UD
10/16/15 CD4   826/43% VL UD
??/??/2017 Descov & Tivicay
2017 VL UD, CD4 stable around 850
2018 VL UD, CD4 stable around 850

Offline Cosmicdancer

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Re: Atripla Taken Every Other Day Still Suppresses HIV at High Rate
« Reply #3 on: April 25, 2019, 09:17:23 am »
I also remember a study that found that reducing the amount of Sustiva in Atripla from 600 mg to 400 mg did not reduce effectiveness but reduced side effects in study participants, but they've never reformulated it. 
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
2/2008 - 5/2015 - undetectable on Atripla
May, 2015 - UD, switched to Complera
September, 2015 - UD, 980 cd4, switched to Stribild (Complera interacted with acid reflux medication)
January, 2016 - Stribild, UD, 950 cd4
June, 2016 - UD, 929 cd4

Offline fabio

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Re: Atripla Taken Every Other Day Still Suppresses HIV at High Rate
« Reply #4 on: April 25, 2019, 11:08:12 am »
Wow! That's some good progress among the "cure for hiv" stuff that has been going on.
Not only it will cut costs,but say you take it every other day and the box has 30 pills,you will have one bottle per 2 month and won't have to supply every months or so. Hope we get more things like these,going from a day,to week and hopefully to months (that would certainly be the best treatment).

Offline tryingtostay

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Re: Atripla Taken Every Other Day Still Suppresses HIV at High Rate
« Reply #5 on: April 28, 2019, 07:49:33 pm »
I wonder what that would mean for Odefesy?  It basically has the better versions of Tenofovir, and Efavirenz.

Offline Grasshopper

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Re: Atripla Taken Every Other Day Still Suppresses HIV at High Rate
« Reply #6 on: April 28, 2019, 11:16:11 pm »
the "cure for hiv" stuff that has been going on.

Suppose you meant "management of hiv"   :)

Offline fabio

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Re: Atripla Taken Every Other Day Still Suppresses HIV at High Rate
« Reply #7 on: April 29, 2019, 07:36:05 am »
Yeah,haha. It feels like a cure,if it became every 4 months.
Considering other people with other conditions don't have such a good management as we do,with low mortality rate.
« Last Edit: April 29, 2019, 07:38:47 am by fabio »

 


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