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Author Topic: EBC-46  (Read 792 times)

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Offline hopeisvague

  • Member
  • Posts: 13
EBC-46
« on: January 31, 2025, 12:21:54 pm »
Kick-and-kill (or shock-and-kill) strategy as a proof of concept functional cure has been in our mind for many years, with names of many potential latency reversing agents (LRA) ringing in our head e.g. vorinostat, panobinostat and bryostatin (even old drugs like metformin and the notorious thalidomide) but so far none of these yield good latent reservoir reactivation performance. Not until tigilanol tiglate or EBC-46 which was approved by FDA in 2024 for the treatment of soft tissue sarcoma and currently available for veterinary purpose has been found capable of attaining up to 90% of the experimental samples when compared to some 20-30% of those LRAs above mentioned.

Stanford Report: Cancer-fighting compound shows immense potential to eradicate HIV

https://news.stanford.edu/stories/2025/01/double-duty-powerful-anticancer-compound-might-also-be-the-key-to-eradicating-hiv

In short:

Quote
Compared to similar-acting agents, EBC-46 excels at activating dormant cells where HIV is hiding, the study found. These “kicked” cells can then be targeted (“killed”) by immunotherapies to fully clear the insidious virus from the body. By pursuing this “kick and kill” strategy with EBC-46, researchers think achieving permanent elimination of HIV in patients – in other words, a cure – is possible.

Stunningly, some analogs deployed in the new HIV-focused study reversed latency in 90% of treated cells – a dramatic four-fold increase over the most powerful latency reversing agent demonstrated to date, bryostatin, which activates only about 20%. “Our studies show that EBC-46 analogs are exceptional latency reversing agents, representing a potentially significant step toward HIV eradication,” Wender said.

201206 351/95000 Started I/T

Offline Mindless

  • Member
  • Posts: 366
Re: EBC-46
« Reply #1 on: February 04, 2025, 05:06:06 am »
That's interesting. Thanks for sharing 🙏🏻
Dx Feb. 2018, CD 320, %14

- Atripla Feb/18 -->
- Complera (generic) 2019 -->
- Dovato (generic) 2021 -->

 


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