Welcome, Guest. Please login or register.
August 14, 2022, 11:47:40 am

Login with username, password and session length


Members
  • Total Members: 36602
  • Latest: Jakrp
Stats
  • Total Posts: 765513
  • Total Topics: 65261
  • Online Today: 135
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 1
Guests: 96
Total: 97

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: IMPAACT P1107 Study - HIV remission in a US woman  (Read 826 times)

0 Members and 1 Guest are viewing this topic.

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 19,198
  • Twitter @JimAllenDublin
    • HIV Lessons
IMPAACT P1107 Study - HIV remission in a US woman
« on: February 15, 2022, 09:42:54 pm »
A woman in the USA has been in remission for 14 months without ART after a stell cell transplant with the CCR5 delta-32 mutation.  I've added links at the end of this post, including the initial 2018 publication of this case.

i-base full write-up:
https://i-base.info/htb/42182

In Short:

Quote
The case involves a woman living with HIV who was diagnosed with acute myelogenous leukemia (AML), a life-threatening cancer, in 2017. The researchers sourced cord blood stem cells from a donor homozygous for the CCR5 delta-32 mutation that prevents expression of the CCR5 co-receptor that most HIV strains use as an entryway into cells.

The aim was to treat the cancer while also generating a new immune system made up of HIV-resistant cells, following the model that has produced three other known cases of likely HIV cures in men (Timothy Ray Brown, Adam Castillejo and the Düsseldorf patient).

A difference with prior cases is that stem cells from umbilical cord blood are less efficient at generating a new immune system after transplantation, so the woman also received stem cells from the peripheral blood of an adult relative who lacked the CCR5 delta-32 mutation.

HIV-1 remission IMPAACT P1107
https://ww2.aievolution.com/cro2201/index.cfm?do=abs.viewAbs&abs=3310

The 2018 publication of this case:
https://www.sciencedirect.com/science/article/pii/S0006497119382333

There is also a thread on the London, Berlin and Dusseldorf patients.
https://forums.poz.com/index.php?topic=70974.msg755934#msg755934
« Last Edit: February 15, 2022, 10:05:40 pm by Jim Allen »
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline Da2020

  • Member
  • Posts: 36
Re: IMPAACT P1107 Study - HIV remission in a US woman
« Reply #1 on: February 20, 2022, 08:03:01 pm »
This is excellent news. They have also mentioned that they could potentially scale this up to 50 people/year. Still not there yet, but good news reagrdless

 


Terms of Membership for these forums
 

© 2022 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.