Welcome, Guest. Please login or register.
September 30, 2022, 11:53:53 am

Login with username, password and session length

  • Total Members: 36692
  • Latest: maxiim
  • Total Posts: 766150
  • Total Topics: 65355
  • Online Today: 129
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 1
Guests: 78
Total: 79


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: HIV-like virus edited out of prmate genome  (Read 2609 times)

0 Members and 1 Guest are viewing this topic.

Offline Cosmicdancer

  • Member
  • Posts: 197
HIV-like virus edited out of prmate genome
« on: December 13, 2020, 10:45:04 am »
This clinical research using CRISPR gene editing technology is encouraging, even though it is probably years away from human clinical trials....

HIV-like virus edited out of primate genome
Coming closer to a cure for human HIV infection

Taking a major step forward in HIV research, scientists at the Lewis Katz School of Medicine at Temple University have successfully edited SIV -- a virus closely related to HIV, the cause of AIDS -- from the genomes of non-human primates. The breakthrough brings Temple researchers and their collaborators closer than ever to developing a cure for human HIV infection.

"We show for the first time that a single inoculation of our CRISPR gene-editing construct, carried by an adeno-associated virus, can edit out the SIV genome from infected cells in rhesus macaque monkeys," said Kamel Khalili, PhD, Laura H. Carnell Professor and Chair of the Department of Neuroscience, Director of the Center for Neurovirology, and Director of the Comprehensive NeuroAIDS Center at the Lewis Katz School of Medicine at Temple University (LKSOM)....

... Of particular significance, the new work shows that the gene-editing construct developed by Dr. Khalili's team can reach infected cells and tissues known to be viral reservoirs for SIV and HIV. These reservoirs, which are cells and tissues where the viruses integrate into host DNA and hide away for years, are a major barrier to curing infection. SIV or HIV in these reservoirs lies beyond the reach of ART, which suppresses viral replication and clears the virus from the blood. As soon as ART is stopped, the viruses emerge from their reservoirs and renew replication.

In non-human primates, SIV behaves very much like HIV. "The SIV-infected rhesus macaque model studied in Dr. Burdo's lab is an ideal large animal model for recapitulating HIV infection in humans," explained Dr. Khalili.

Read the full article at the link below.
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
2/2008 - 5/2015 - undetectable on Atripla
May, 2015 - UD, switched to Complera
September, 2015 - UD, 980 cd4, switched to Stribild (Complera interacted with acid reflux medication)
January, 2016 - Stribild, UD, 950 cd4
June, 2016 - UD, 929 cd4

Offline Mindless

  • Member
  • Posts: 357
Re: HIV-like virus edited out of prmate genome
« Reply #1 on: December 19, 2020, 04:36:09 am »
This seems an interesting approach. There's an article about it also on poz website: https://www.poz.com/article/crispr-snips-simian-hiv-monkeys-cells-even-viral-reservoir

I wonder how similar is SIV in monkeys to HIV in humans and if the results actually bring any hope for human trials. If they'll ever get there.

Offline Almost2late

  • Member
  • Posts: 1,447
Re: HIV-like virus edited out of prmate genome
« Reply #2 on: December 19, 2020, 07:58:05 am »
Sounds wonderful but I'm pretty
sure they'll be dragging out this research for decades.

I recently learned how CRISPR has cured a woman of sickle cell disease here in the US.. https://www.npr.org/sections/health-shots/2020/12/15/944184405/1st-patients-to-get-crispr-gene-editing-treatment-continue-to-thrive

I believe this gene editing is the holy grail cure for HIV and possibly every disease. But the greed of the pharmaceutical industry may keep hiv+ ppl from it for a long time to come.

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 19,483
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: HIV-like virus edited out of prmate genome
« Reply #3 on: December 22, 2020, 10:53:58 pm »
A few years ago it was the same Dr. Khalili studies at the Lewis Katz School of Medicine at Temple University that sparked a hype as CRISPR-Cas9 approach was shown to work on HIV in labs on human cells and live animals (rodents). Lot was learned but the hype was just that.

Good that progress is made and this is continued to be investigated as a possible tool in advancing HIV treatment & understanding, not going to hold my breath though on the cure aspect.

https://www.poz.com/article/maybe-crispr-gene-editing-easy-way-attack-hiv (HIV developing possible resistance to CRISPR)
« Last Edit: December 22, 2020, 11:18:46 pm by Jim Allen »
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP


Terms of Membership for these forums

© 2022 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.