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Meds, Mind, Body & Benefits => Research News & Studies => Topic started by: Jim Allen on February 15, 2022, 09:42:54 pm

Title: IMPAACT P1107 Study - HIV remission in a US woman
Post by: Jim Allen on February 15, 2022, 09:42:54 pm
A woman in the USA has been in remission for 14 months without ART after a stell cell transplant with the CCR5 delta-32 mutation.  I've added links at the end of this post, including the initial 2018 publication of this case.

i-base full write-up:
https://i-base.info/htb/42182

In Short:

Quote
The case involves a woman living with HIV who was diagnosed with acute myelogenous leukemia (AML), a life-threatening cancer, in 2017. The researchers sourced cord blood stem cells from a donor homozygous for the CCR5 delta-32 mutation that prevents expression of the CCR5 co-receptor that most HIV strains use as an entryway into cells.

The aim was to treat the cancer while also generating a new immune system made up of HIV-resistant cells, following the model that has produced three other known cases of likely HIV cures in men (Timothy Ray Brown, Adam Castillejo and the Düsseldorf patient).

A difference with prior cases is that stem cells from umbilical cord blood are less efficient at generating a new immune system after transplantation, so the woman also received stem cells from the peripheral blood of an adult relative who lacked the CCR5 delta-32 mutation.

HIV-1 remission IMPAACT P1107
https://ww2.aievolution.com/cro2201/index.cfm?do=abs.viewAbs&abs=3310

The 2018 publication of this case:
https://www.sciencedirect.com/science/article/pii/S0006497119382333

There is also a thread on the London, Berlin and Dusseldorf patients.
https://forums.poz.com/index.php?topic=70974.msg755934#msg755934
Title: Re: IMPAACT P1107 Study - HIV remission in a US woman
Post by: Da2020 on February 20, 2022, 08:03:01 pm
This is excellent news. They have also mentioned that they could potentially scale this up to 50 people/year. Still not there yet, but good news reagrdless