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Meds, Mind, Body & Benefits => Research News & Studies => Topic started by: bluedog7000 on April 21, 2021, 08:16:54 am

Title: Can HIV Treatment Be Taken Just 4 Days a Week? Studies are very promising
Post by: bluedog7000 on April 21, 2021, 08:16:54 am
Here's an article

https://www.poz.com/article/can-hiv-treatment-taken-just-4-days-week#lid=d5ab18bd98.613e8705e8

I wonder if this can be done with the current medications or only the future ones. I wonder if anyone has tried that and if so with what medication?
Title: Re: Can HIV Treatment Be Taken Just 4 Days a Week? Studies are very promising
Post by: Jim Allen on April 21, 2021, 08:42:19 am
Hiya.

Welcome to the forum.

I know some people have, mixed results, study results seem promising though.

What medication are you taking and how are you getting on? Is four days a week something you are considering and if so have you discussed four days a week with your doctor?

There are a number of studies into four days a week and threads on them if you are looking for more information.

Caution over French study only taking ART 4 days a week
http://i-base.info/htb/36517

FOTO: https://www.poz.com/article/hiv-efavirenz-intermittent-16959-8019

Thread:
Every Other Day: https://forums.poz.com/index.php?topic=72189.msg

Thread: Newer HIV Regimens May Require Less Strict Adherence
https://forums.poz.com/index.php?topic=73003.0

Thread: Fours days a week
https://forums.poz.com/index.php?topic=72799.msg

Title: Re: Can HIV Treatment Be Taken Just 4 Days a Week? Studies are very promising
Post by: bluedog7000 on April 21, 2021, 12:34:04 pm
I'm on Dovato now (from Biktarvy), supposedly it does less damage but not sure all about it.
Title: Re: Can HIV Treatment Be Taken Just 4 Days a Week? Studies are very promising
Post by: Matths on April 21, 2021, 03:52:54 pm
Hi there, based on what my doctor tells me and the existing literature I would not support an approach of experimenting with dosing despite some studies that might suggest otherwise. I am Dovato too and the reasoning behind this drug was to reduce the number of drugs in the single pill to reduce the overall exposure to medications over time and with doing that avoiding possible side effects that may come up with long-term exposure. But especially for the 2-drug combo pills the recommendation is to take them daily. I do not want to comment on other drugs but speak for Dovato only. As you can see on page 18/19, the half-life time for the 2 drugs in this combo is 14 hours for dolutegravir and 13-18 hours for lamivudine. That means that the drug concentration is reduced 50% at those time points after taking the pill. While missing a drug occasionally may not result in virological failure if itís a single event, doing it routinely may change that risk. Therefore, it makes most sense to not allow the drug concentration in your blood fall too low regularly and reach levels that donít control the virus. Clearly, my thinking is if I tolerate the medication well and it keeps me UD to take it regularly. And if I had side effects, Iíd rather switch medications to a regime that works rather than changing (reducing) the daily intake to any other schedule and thereby increasing my risk to end up with medication-resistant HIV. Best Matt
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211994s000lbl.pdf
Title: Re: Can HIV Treatment Be Taken Just 4 Days a Week? Studies are very promising
Post by: nethan1621 on June 01, 2021, 10:11:52 pm
Whos doing 4 days a week ?
Title: Re: Can HIV Treatment Be Taken Just 4 Days a Week? Studies are very promising
Post by: Giancarlo on October 05, 2021, 10:25:36 am
I have been doing 4 days a week for about 3 years now.
I'm on Atripla, it is an "old" medication but it works well for me and is available as a generic drug, so all in all my treatment costs "only" about 140Ä per month to my country - and 0Ä to me :)

In France, it is stated in the official guidelines that such a strategy (4 days a week) can be considered, but case by case.