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Author Topic: Dovato DTG + 3TC  (Read 3531 times)

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Offline connor

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  • Posts: 11
Dovato DTG + 3TC
« on: April 09, 2019, 04:43:16 am »
Amazing medication that I highly recommend. I've had zero side effects on this and you can take with or without food. Great news about the trial I have been on since March 2016. The new dual therapy medication of Dolutegravir & Lamivudine (DTG/3TC) has been approved and will be called Dovato.

More information here...

 https://www.businesswire.com/news/home/20190408005806/en/FDA-approves-ViiV-Healthcare’s-Dovato-dolutegravirlamivudine-once-daily
04 Mar 2014 Negative test results
14 May 2014 CD4 530 VL 10,000 TDF+FTC+RAL+DRV+RTV (started meds during seroconversion. HIV-1 subtype B)
28May2014 CD4 630 VL 66,182
17 Jun 2014 CD4 704 VL UD TDF+FTC+RAL
26 Aug 2014 CD4 646 VL UD
28 Oct 2014 CD4 797 VL UD TDF+FTC+EVG/c
12 May 2015 CD4 730 VL UD
08 Sep 2015 CD4 787 VL UD
13 Nov 2015 CD4 658 VL UD DTG+3TC+ABC (hypersensitivity ABC)
20 Nov 2015 CD4 718 VL UD TDF+FTC+RAL
21 Mar 2016 CD4 889 VL UD DTG+3TC (Dual Therapy. Gemini Study)
13 Jun 2016 CD4 1006 VL UD
29 Aug 2016 CD4 1081 VL UD
021216 CD4  801  VL UD
130317 CD4 1070 UD 35%
010617 CD4 994 UD 42%
161117 CD4 1168 UD 34%
200418 CD4 982 UD 38%
041018 CD4 681 UD 33%
010419 CD4 978 UD 35%
200819 CD4 833 UD 31%
180220: Start Dovato
110820 CD4 996 UD 40%

Online Jim Allen

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Re: Dovato DTG + 3TC
« Reply #1 on: April 09, 2019, 05:40:42 am »
Glad to hear this combo is working well for you.

Best, Jim
HIV 101 - Everything you need to know
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Read more about Testing here:
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Read about Treatment-as-Prevention (TasP) here:
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You can read about HIV prevention here:
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Read about PEP and PrEP here
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Offline connor

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  • Posts: 11
Re: Dovato DTG + 3TC
« Reply #2 on: April 09, 2019, 05:57:33 am »
 Thanks Jim 🙂
04 Mar 2014 Negative test results
14 May 2014 CD4 530 VL 10,000 TDF+FTC+RAL+DRV+RTV (started meds during seroconversion. HIV-1 subtype B)
28May2014 CD4 630 VL 66,182
17 Jun 2014 CD4 704 VL UD TDF+FTC+RAL
26 Aug 2014 CD4 646 VL UD
28 Oct 2014 CD4 797 VL UD TDF+FTC+EVG/c
12 May 2015 CD4 730 VL UD
08 Sep 2015 CD4 787 VL UD
13 Nov 2015 CD4 658 VL UD DTG+3TC+ABC (hypersensitivity ABC)
20 Nov 2015 CD4 718 VL UD TDF+FTC+RAL
21 Mar 2016 CD4 889 VL UD DTG+3TC (Dual Therapy. Gemini Study)
13 Jun 2016 CD4 1006 VL UD
29 Aug 2016 CD4 1081 VL UD
021216 CD4  801  VL UD
130317 CD4 1070 UD 35%
010617 CD4 994 UD 42%
161117 CD4 1168 UD 34%
200418 CD4 982 UD 38%
041018 CD4 681 UD 33%
010419 CD4 978 UD 35%
200819 CD4 833 UD 31%
180220: Start Dovato
110820 CD4 996 UD 40%

Online Jim Allen

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Re: Dovato DTG + 3TC
« Reply #3 on: April 09, 2019, 09:10:46 am »
We have had a few threads since 2016 on this but glad its finally got the nod from the FDA and at least the name "Dovato" is something i can pronounce for a change.  ;D

https://forums.poz.com/index.php?topic=63655.msg
https://forums.poz.com/index.php?topic=68478.msg
https://forums.poz.com/index.php?topic=69989.msg

POZ.com
https://www.poz.com/article/fda-approves-viivs-twodrug-dovato-treat-hiv


Quote
The Food and Drug Administration (FDA) has approved ViiV Healthcare’s fixed-dose, single-tablet regimen Dovato (dolutegravir/lamivudine) to treat HIV among those new to antiretroviral (ARV) therapy whose virus does not have mutations associated with either of the drugs in the combination tablet.

Dovato is the second HIV regimen to be approved that includes just two ARVs rather than three or more, as has been standard. The first two-drug regimen, Juluca (dolutegravir/rilpivirine), got the nod from the FDA in November 2017. Dovato is the first to be approved for people starting HIV treatment for the first time.

Both Dovato and Juluca are based on the integrase inhibitor dolutegravir (sold separately as Tivicay). The lamivudine component of Dovato belongs to the nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) class of ARVs while the rilpivirine component of Juluca is a non-nucleoside reverse transcriptase inhibitor (NNRTI).

Dovato has a black box warning for those with hepatitis B virus (HBV). Consequently, those starting the HIV regimen should receive HBV testing. Because HBV has been shown to develop resistance to the lamivudine component of Dovato, those who are HIV/HBV coinfected and opt to take the HIV regimen are advised to receive additional hep B treatment. 
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline life2

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  • Posts: 52
Re: Dovato DTG + 3TC
« Reply #4 on: April 29, 2019, 12:23:22 am »
Great news! I tried this combo for a month based on the results of the Gemini study with great results and none of the gassy side effects of the tenofovir based regimen I've been on for six years since my diagnosis.

Pricing should be interesting as both of these drugs are available generically.

Offline gorka

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Re: Dovato DTG + 3TC
« Reply #5 on: April 29, 2019, 01:45:16 am »
I am not aware of generic DTH being approved yet

Offline life2

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  • Posts: 52
Re: Dovato DTG + 3TC
« Reply #6 on: April 29, 2019, 03:37:19 am »
DTG is offered generically under the the names Instgra, Naivex and Doluvir that I'm aware of.

Offline life2

  • Member
  • Posts: 52
Re: Dovato DTG + 3TC
« Reply #7 on: May 04, 2019, 01:07:33 am »
Well this is pretty disappointing. $27,540/yr

https://fairpricingcoalition.org/2019/04/09/dovato-approval-price/


To put this in perspective I can pay for a flight from the US to India, hotel and cash for the same combo every month for about the same cost!

But hey, at least it's more affordable :(
« Last Edit: May 04, 2019, 01:15:55 am by life2 »

Offline Almost2late

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  • Posts: 1,358
Re: Dovato DTG + 3TC
« Reply #8 on: May 18, 2019, 11:52:00 pm »
This is interesting, this is the same as my Triumeq minus the Abacavir component.  Wonder if it would work for me?

Offline PittGurl

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  • Posts: 351
Re: Dovato DTG + 3TC
« Reply #9 on: September 11, 2019, 10:25:15 pm »
Following bc i just posted on this as my dr is asking me if i want to switch from Triumeq to this
Infected ~5/16/15-7/19/15
8-2-15    CD4=286; VL=43800; 15% WB Pos Test Confirmed (waiting for genotype to start Triumeq)
9-4-15    Started Triumeq thanks to the people on board encouraging me :)
9-21-15    CD4=570; VL 26; 30% 16 days on Triumeq….
10-27-15   CD4=522; VL=UNDETECTABLE!!!; 29%    7 wks, 4 days on Triumeq
1-28-16    CD4=479; VL=UD; 31% almost 5 mo on Triumeq
4-27-16    CD4=580; VL=UD; 32%
7-28-16    CD4=991; VL=UD; 38% almost 1 year on Triumeq
8-3-16    ONE YEAR DX
10-27-16    CD4=765; VL=UD; 39%
3-8-17   CD4=709; VL=27; 39%
7-13-17   CD4=942; VL=UD; 41%
10/12/17   CD4=626; VL=UD; 39%
1/21/18    CD4=650; VL=UD; 40%
4/26/18   CD4=893; VL=UD; 39%
8/9/18   CD4=858; VL=UD; 41%
12/27/18   CD4=841; VL=UD; 41%
4/24/19   CD4=751; VL=UD; 39%
8/27/19   CD4=719; VL=UD; 36%
10/31/19   CD4=746; VL=UD; 37%

Offline life2

  • Member
  • Posts: 52
Re: Dovato DTG + 3TC
« Reply #10 on: September 14, 2019, 02:38:45 pm »
The data on this combo is pretty strong. The main concern on a switch to a two drug combo would be adherence.

Offline Kangaroo

  • Member
  • Posts: 36
Re: Dovato DTG + 3TC
« Reply #11 on: December 17, 2020, 05:57:19 pm »
I feel very happy to hear that Dolutegravir + Lavimudine has been working well for you!

I would like to have access to that treatment in my country too. Currently, I take Dolutegravir + Lamivudine + Tenofovir (300mg), I feel unsafe to use this last because of the long term effects it has reported to cause.

I will ask my doc about the possibility, and accessibility, of this 2-drug ART, but I think it will only be available if the Ministry of Health recommend it.

Please keep us posted about how is yout treatment going.
Looking at the sea again.
Tides they rise and fall and then they rise again.

29/03/2017: Confirmed POZ(VL: N/A CD4: 303)
26/04/2017: VL 66.576 CD4 575)
12/05/2017: Start of DTC + TDF + 3TC
26/06/2017: VL 58 CD4 628,5
20/07/2017: VL Undetectable
09/05/2018: VL UD CD4 650,7@32,5%
08/11/2018: VL UD CD4 617,4@31,4%
29/05/2019: VL UD CD4 677,8@33,3%
12/11/2019: VL UD CD4 730,0@34,6%
30/05/2020: VL UD CD4 801,8@36,7%
11/12/2020: VL UD CD4 652,0@39,1%

 


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