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Meds, Mind, Body & Benefits => Research News & Studies => Topic started by: Miss Philicia on January 28, 2010, 04:13:04 pm

Title: Premature Aging of the Brain Seen in HIV Patients
Post by: Miss Philicia on January 28, 2010, 04:13:04 pm
link (http://www.healthfinder.gov/news/newsstory.aspx?docID=635303)

Premature Aging of the Brain Seen in HIV Patients
With AIDS growing among seniors, decline in brain function a serious concern, researchers say.


TUESDAY, Jan. 26 (HealthDay News) -- Premature aging is striking the brains of people infected with the virus that causes AIDS, new research suggests.

It's not clear if the virus or the drugs that treat it -- or both -- are contributing to the aging. But one thing is clear: The blood flow in HIV patients is about the same as in those of uninfected people who are 15 to 20 years older.

"The graying of the AIDS patient community makes this infection's effects on the brain a significant source of concern," study author Dr. Beau Ances, an assistant professor of neurology at Washington University in St. Louis, said in a university news release.

"Patients are surviving into their senior years, and a number of them are coming forward to express concerns about problems they're having with memory and other cognitive functions," Ances said.

An estimated 14 percent to 18 percent of all AIDS patients in the United States are more than 50 years old, and older people face one of the highest rates of new infections. By 2015, people over the age of 50 may account for more than half of all AIDS patients.

In the study, researchers used MRI scans to study the blood flow in the brains of 26 HIV-infected people and 25 other people who weren't infected. The average age and education level of the participants were similar.
The researchers found reduced blood flow in the brains of younger HIV-infected patients who were infected recently, not just the older ones.

The study was released online in advance of publication in the Feb. 1 print issue of the Journal of Infectious Diseases.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: WillyWump on January 28, 2010, 09:24:41 pm
Yes, this is what I fear the most. With the aging of the HIV pool this is probably going to be a definite issue.  :(

-Will
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: mecch on January 28, 2010, 09:52:03 pm
Doesn't anyone have an electronic / athens login to get the real paper?  I'm off campus until the end of february.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Miss Philicia on January 28, 2010, 09:55:08 pm
Yes, this is what I fear the most. With the aging of the HIV pool this is probably going to be a definite issue.  :(

-Will

I'm just happy that in my 22nd year of infection they've begun to study this.  At least in three years when I morph into Terry Schiavo I'll at least know what's going on for a period of five minutes.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: veritas on January 29, 2010, 06:14:59 am


Here's the abstract (full paper needs to be purchased as I do not have access):

http://www.ncbi.nlm.nih.gov/pubmed/20047503?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3

Although concerning, it is certainly not unheard of, we have all heard of Aids Dementia. Here is an abstract with respect to HIV and alchohol comorbidity:

http://www.ncbi.nlm.nih.gov/pubmed/16959813?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed

If you want some unguaranteed insurance, try green tea (it won't hurt you and might help, it helped rats):

http://www.ncbi.nlm.nih.gov/pubmed/20064606?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

v

Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: minismom on January 29, 2010, 06:27:13 am
Mim's *only* 9 1/2 years into her infection, but her cognitive functions have crapped out in so many ways: memory (long-term, short-term, visual, and auditory), reasoning, learning new skills, muscle function, coordination, and the list goes on.  Unfortunatly, we'll never have a base-line of what she was (could have been / would have been) without her infection.  

It seems like studies could be done using the cognitive functions / blood flow of LTNP.  These folks have never been on medication so it would reason that if their cognition is also impaired, then it must be from the virus.  If not, then the meds would be more to blame.  If they are impaired, but not to the same degree, then we'd be looking at a combination of virus and meds.  

It is interesting that the article notes reduced blood flow in "young" pozzies and not just the older populus.  It's not clear, however, if they are referring to "young" in age or "young" in infection?  Also, what is "young"?  It does beg the need of more than just blood tests when it comes to HIV.  Baseline cognitive testing and MRI scans (and DEXA scans) along with annual or bi-annual repeats certainly need to be done.  I'd like to also see a shift from treating the virus to treating the person.  

I wonder why there's been such an influx of articles about this subject lately.

Mum
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: freewillie99 on January 29, 2010, 07:13:30 am
It's well known that regular cardiovascular exercise increases blood flow to the brain.  Think of a spinning class as insurance against going loopy.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Miss Philicia on January 29, 2010, 09:52:54 am
Green tea and jogging will do the trick, folks.  Nothing to see here, let's just move along.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: skeebo1969 on January 29, 2010, 10:06:14 am
It's well known that regular cardiovascular exercise increases blood flow to the brain.  Think of a spinning class as insurance against going loopy.

Oh yea, that will do the trick.  I prefer to just let my hair grow long and heavy...  I think it pulls all the blood to my scalp.  On it's way to the scalp it passes by the brain.  I'm still a crazy bastard though..
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Rev. Moon on January 29, 2010, 11:17:12 am
Green tea and jogging will do the trick, folks.  Nothing to see here, let's just move along.

What about poppers? They increase bloodflow to the brain. Maybe we need to increase their intake in our diets.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Miss Philicia on January 29, 2010, 11:25:11 am
What about poppers? They increase bloodflow to the brain. Maybe we need to increase their intake in our diets.

That would definitely explain why I'm still so sharp in my thinking, but I doubt I'll be getting requests for what brand I use as is currently the case in the the thread about black walnuts.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Rev. Moon on January 29, 2010, 11:31:42 am
That would definitely explain why I'm still so sharp in my thinking, but I doubt I'll be getting requests for what brand I use as is currently the case in the the thread about black walnuts.

I'd venture to say you are a Jungle Juice type of patient.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Miss Philicia on January 29, 2010, 11:44:16 am
I'd venture to say you are a Jungle Juice type of patient.

Nope.  I snag imported stuff from Fort Troff.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: veritas on January 29, 2010, 12:51:21 pm

I wouldn't scoff at the benefits of green tea and blood flow as well as other anectdotal evidence surrounding its benefit. Here are a few studies:

http://www.dailymail.co.uk/health/article-1031192/How-daily-cup-green-tea-healthy-heart-minutes.html

http://www.telegraph.co.uk/health/2234806/Green-tea-helps-prevent-heart-disease.html

http://www.usnews.com/health/family-health/articles/2008/07/09/green-tea-relaxes-your-arteries-too.html

http://www.webmd.com/food-recipes/news/20060217/green-tea-may-do-wonders-for-brain

http://www.israelnationalnews.com/News/News.aspx/123968

http://www.greentealibrary.com/GTBrainAnim05.htm

http://www.chron.com/disp/story.mpl/nation/4293866.html

v
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: freewillie99 on January 29, 2010, 01:16:20 pm
Oh yea, that will do the trick.  I prefer to just let my hair grow long and heavy...  I think it pulls all the blood to my scalp.  On it's way to the scalp it passes by the brain.  I'm still a crazy bastard though..

Heh...based on that response I'm guessing that you've already achieved loopy status, skeebo.  Keep sitting your fat ass on the sofa and chain smoking those unfiltered.  That's the ticket.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Hellraiser on January 29, 2010, 01:52:29 pm
I might take Green Tea if I could stomach the stuff.  I gag at the smell of it.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: veritas on January 29, 2010, 01:57:12 pm

Hellraiser,

Have you ever tried it with honey and a little half and half? It makes it easier to take.

v

Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: leatherman on January 29, 2010, 02:38:15 pm
I might take Green Tea if I could stomach the stuff.  I gag at the smell of it.
I'm with you on this one.  ;)

Green tea, liver and brussel sprouts are the only drink/food items that leatherman never ingests. Yuck! Since I'll never have enough hair for dreds, I'll just up my popper usage and hope that helps keep my noggin working longer. :D LOL
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: elf on January 30, 2010, 12:32:45 am
Go eat some fish  ;D :)
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Hellraiser on January 30, 2010, 02:20:06 am
Go eat some fish  ;D :)

I also hate the taste of fish.  It's just so fishy.  Surely I eat something that's good for me right?  Brocolli? Pecans?  Any fruit that isn't a melon?
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: John2038 on January 30, 2010, 10:28:17 am
Assuming no drugs interactions, nasty side effects and so, wondering if the viagra or the vinpocetine (http://www.ncbi.nlm.nih.gov/pubmed/14624946) could contribute to improve our brain condition.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Nestor on January 30, 2010, 10:36:59 am
I agree with Minismom:

Quote
It seems like studies could be done using the cognitive functions / blood flow of LTNP.  These folks have never been on medication so it would reason that if their cognition is also impaired, then it must be from the virus.  If not, then the meds would be more to blame.  If they are impaired, but not to the same degree, then we'd be looking at a combination of virus and meds.  

This sounds like something that would be worth doing.  

But actually, that New York Magazine article that caused such heated discussion here a while back already had a few interesting things to say on the topic:

At first, it says:

"Researchers are convinced that bone loss, perhaps more clearly than the other conditions, is a direct side effect of the medications, while the brain issues are more likely to be related to HIV itself."

But then it seems to take that back:

"For the problems with dementia, most researchers blame HIV itself, which it turns out can continue replicating in, and damaging, the brain despite being controlled in the bloodstream.....

But in many cases of dementia, there are no signs of viral activity around the brain, suggesting other factors may be at play. At the Manhattan HIV Brain Bank at Mount Sinai, researchers have dissected the skull contents of 250 volunteers who agreed to a series of psychological interviews and neurological exams, then promised to hand over their brains at death.... According to Dr. Susan Morgello, who directs the lab, most people who showed signs of dementia while alive do not have evidence of HIV in their autopsied brain. What they do have in common, she says, is evidence of persistent inflammation, which alone could account for the cognitive damage.

But Morgello is investigating something that’s both more surprising and less so: The inflammation might be caused as much by the patient’s emotional and psychiatric burden as the virus’s pathological course. “We have screamingly high rates of major depressive disorders, substance abuse and dependency, and post-traumatic-stress disorder...."



The vicious circle, for me at least, is that having HIV is in itself depressing!  And if someone already felt depressed before getting HIV (which is the case, I think, with many of us) getting HIV didn't exactly help reduce the depression.  

With all this, I think actively looking into anything that might have an anit-inflammatory or anti-depressant effect, such as the suggestions here about green tea or exercise, is a very reasonable thing to be doing.  

As someone who has loved green tea for most of my life, may I ask the haters of green tea a question?  Precisely what green teas have you tried?  Is it possible that they were just not very good ones, or weren't prepared properly?  


Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Miss Philicia on January 30, 2010, 10:38:14 am
I also hate the taste of fish.  It's just so fishy.  

That means what you're eating isn't very fresh, or you're choosing overly oily
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Dachshund on January 30, 2010, 10:42:28 am
Hellraiser,

Have you ever tried it with honey and a little half and half? It makes it easier to take.

v



Clear the brain and clog the arteries.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: skeebo1969 on January 30, 2010, 10:48:07 am
Heh...based on that response I'm guessing that you've already achieved loopy status, skeebo.  Keep sitting your fat ass on the sofa and chain smoking those unfiltered.  That's the ticket.

Guessing, assuming, which ever your wrong...  It's OK though, go pump some iron!
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: veritas on January 30, 2010, 10:48:43 am
John,

Early studies showed vinpocetine somewhat unsafe with therapeutic dose:

http://www.ncbi.nlm.nih.gov/pubmed/12535455?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_Discovery_RA&linkpos=3&log$=relatedreviews&logdbfrom=pubmed

Viagra, on the other hand:

http://www.ncbi.nlm.nih.gov/pubmed/17556793?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5

Yea!

v
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: veritas on January 30, 2010, 10:53:49 am


"Clear the brain and clog the arteries"


Not if you exercise !
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: freewillie99 on January 30, 2010, 11:11:39 am
Guessing, assuming, which ever your wrong...  It's OK though, go pump some iron!

lol...puff, puff...

Thanks for the suggestion.  Spoken like a true couch potato.  Although "pumping iron" is beneficial, particularly for one's bone density as we age, currently I prefer my regimen of yoga, spinning, and pilates.  Throw in some daily green tea and fish oil, and I'm doing what I can to keep inflammation at bay.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: skeebo1969 on January 30, 2010, 11:17:07 am
lol...puff, puff...

Thanks for the suggestion.  Spoken like a true couch potato.  Although "pumping iron" is beneficial, particularly for one's bone density as we age, currently I prefer my regimen of yoga, spinning, and pilates.  Throw in some daily green tea and fish oil, and I'm doing what I can to keep inflammation at bay.

You know I just browsed over your eloquent posting history since you joined the forums.  Perhaps getting off the roids and going natural will serve you better, you seem a bit testy there.   In the mean time, go pick your next fight... who will it be?
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: freewillie99 on January 30, 2010, 11:19:17 am
You know I just browsed over your eloquent posting history since you joined the forums.  Perhaps getting off the roids and going natural will serve you better, you seem a bit testy there.   In the mean time, go pick your next fight... who will it be?

LOL...how lovely.  Guess I just don't tolerate morons too well.  Congrats for making the grade!
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: leatherman on January 30, 2010, 11:24:24 am
may I ask the haters of green tea a question?  Precisely what green teas have you tried?  Is it possible that they were just not very good ones, or weren't prepared properly?
As a good ol' Southern boy, tea should be dark and have at least a cup and a half of sugar per gallon to be acceptable to drink. ;) I tried green tea from several bottled drink manufacturers, tried it when friends made it, tried it at a couple of restaurants and tried making it at home. If it's not so weak as to have no more flavor than water, then it just tastes bitter or kinda rank, IMO. For disclosure purposes, I should mention that I have been drinking at least a 2-liter bottle of Coca-Cola a day for the last 28 years. ;D

In the mean time, go pick your next fight... who will it be?
hey Skee, whaddayouknow? I didn't think this thread was gonna go all freaky. what's with willy that he thinks you're fat? that's just weird man.  :D  ;D LOL never boring around here is it?
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: skeebo1969 on January 30, 2010, 11:25:40 am
LOL...how lovely.  Guess I just don't tolerate morons too well.  Congrats for making the grade!

LOL... yes how lovely it is.   Glad I joined the ranks with all the others. ;D  
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: skeebo1969 on January 30, 2010, 11:27:21 am
hey Skee, whaddayouknow? I didn't think this thread was gonna go all freaky. what's with willy that he thinks you're fat? that's just weird man.  :D  ;D LOL never boring around here is it?

LMAO yes, especially when I think my avatar clearly shows my beautiful chest and my trim waistline!!
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: veritas on January 30, 2010, 11:33:20 am

Nestor,

Informative post !

Inflamation is certainly one of the many problems, being HIV+.

I enjoy green tea, also, at least two cups /day.

v
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Nestor on January 30, 2010, 12:11:51 pm

Why did the conversation take the turn it did?  Why have so many conversations here taken the turns they have?  I'd like to do a bit of analysis, because this sort of acrimony seems to surface a lot, and to vitiate otherwise enlightening conversations:

FreeWillie said:

Quote
It's well known that regular cardiovascular exercise increases blood flow to the brain.  Think of a spinning class as insurance against going loopy.

The first reply he recieved was:

Quote
Green tea and jogging will do the trick, folks.  Nothing to see here, let's just move along.

The very next reply was:

Quote
Oh yea, that will do the trick.  I prefer to just let my hair grow long and heavy...  I think it pulls all the blood to my scalp.  On it's way to the scalp it passes by the brain.  I'm still a crazy bastard though..

Now, all of this can come very close to sounding like sarcasm--even like mockery or ridicule.  I'm sure that they were intended to be merely good-natured, but they ran the risk of sounding otherwise.  Nobody suggested that green tea or exercise would be a magic solution or that there was "nothing more" to talk about.  If the suggestion sounded so comical to you, what else would you have us do?  The choices are 1. To become medical researchers ourselves and devote the rest of our lives to finding a cure (noble but not exactly possible for everyone) 2. To do nothing and gather roses while we may (which may not be a bad idea at all, but I doubt highly that people who take that solution are involved in these forums) 3. To make despairing noises, and 4. To look into and talk about small things that we can do that just might help mitigate the effects of problems such as the one that the OP brought before us in this thread.  That last option is called "lighting a candle rather than cursing the darkness."  I do not understand why it is often met with sarcasm or even ridicule. 

I am sure that the comments which led the conversation to degenerate were meant in good fun but it can be frustrating to post something serious and intended to be helpful and to be met immediately with something of that sort--especially when the levity is not mixed with anything in the way of a more thoughtful response. 

As an example, a few months ago someone posted saying that he was really tired every afternoon.  He said he drank starbucks coffee every day and it didn't help.  I posted a comment wondering whether life without caffeine might improve things.  I talked about my own problems with afternoon tiredness, discussed whether napping was a good idea, talked about sugar, msg, and the good and bad aspects of caffeine; finally I suggested trying life without caffeine and seeing what it would do.  One person wrote something similar to what I suggested about caffeine.  After that there was not a single serious response either from the OP or from any other person complaining about afternoon fatigue.  Instead there was just an orgy of one-liners about how they loved Starbucks so much they could kiss the coworker who brought it to them, and how it went well with M&Ms, and then a lot of talk about codeine and other things, analagous to the digression on poppers in this conversation here.  (It is telling that the same people who were reveling in their love for caffeine, candy, and various medicines were the same ones who had been complaining about exhaustion!) Not a single meaningful reply to my statement about caffeine (ironic that I should mention it here, in the same thread in which I'm talking about my love for green tea!) I was left scratching my head--why had I bothered to take the time and energy to post some serious thoughts on the question, only to have the conversation take such an unserious turn? 

My point is that it's fine to mix banter and humor with serious discussion--God knows we need some humour--but when that's all the response made to a serious statement that had been intended to be helpful, it is unsurprising that the person who originally made the statement will take affront. 



Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Nestor on January 30, 2010, 12:44:05 pm



Veritas,

When I first saw your suggestion about adding half and half to green tea, my first response--I actually started posting it--was to say "That's a sacrilege!"  Then I realised the degree to which my idea of green tea was still influenced by Japanese opinions: like all people who got their tea-drinking habits from the Han Chinese, the Japanese have traditionally regarded milk with horror.  (Ironically, today in Japan it is popular to have "Matcha au lait"--strong green tea with milk and sugar).  But I picked up my tea-drinking habits from traditional Japanese friends twenty years ago and have hardly changed them. 

Yet, all around the western periphery of China, among Manchus, Mongols, Tibetans, etc--tea is drunk with milk.  In Tibet the staple drink is green tea with salt and yak-butter.  I tasted it expecting something bizarre and was surprised to find it vaguely familiar.  After a few minutes I realized what it tasted like: a cream of vegetable soup! 

The Chinese until the Tang dynasty liked to drink tea with orange peels, onions, ginger, salt, and all sorts of other stuff in it; in the Tang a kind of purism set in--"don't add anything, that's vulgar, appreciate the taste in itself"--and has lasted to this day, with the exception of various floral additions like jasmine and the orange blossoms which suggested our Earl Grey.

So cream or milk is not a sacrilege or even a bad idea, although I wouldn't add them to any really good quality tea, just as I would not take really good quality wine and mix it with anything in a cocktail. 

Leatherman,

Now we're even, since I feel about Coca-Cola the way you do about liver and green tea, which are things I love. (I also used to hate brussels sprouts, and I still don't love them, but I finally figured out that if they are neither undercooked (as they usually are in modern restaurants) nor over-cooked (as they used to be) and if they are cooked with a lot of bacon and onions and garlic and butter and broth(no purism here!  I think most vegetables are better with bacon and onions and garlic and butter and broth) I quite like them. 

George Orwell wrote an article about tea in which he said basically the same thing you say: green tea is bad because it is not black tea, and tea is supposed to be black.  (He did, however, hate the idea of sugar in tea: he felt that once one added sugar there was no further flavor of tea.)  If you ever have a chance to try a good green Tie Guan Yin, or one of the "greener" Taiwanese oolongs, or a really nice Japanes Sencha, I would recommend it.  But I can understand how you feel.  Lately I've come to like quite spicy food, and sometimes "normal" food will taste dull to me by comparison.  I can easily see that after coca-cola or black tea, green tea will taste "like water" by comparison. 

One more thing--from your photographs you look rather thin--how is it that you can drink two gallons of coca-cola every day and remain thin, while I drink mainly water and green tea and can never lose those last 20 pounds?  I guess it must be all that bacon I cook with the vegetables.....
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Nestor on January 30, 2010, 12:46:52 pm

Back to the topic at hand (sorry for the long digression!)

Is there a relationship between blood flow and inflammation?
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Hellraiser on January 30, 2010, 01:44:40 pm
That means what you're eating isn't very fresh, or you're choosing overly oily

This might be true I actually went to a high end restaurant once and ordered fish it was much better than I expected and without the fishy taste.  The texture wasn't completely awful either.  :D
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: freewillie99 on January 30, 2010, 01:47:25 pm
This might be true I actually went to a high end restaurant once and ordered fish it was much better than I expected and without the fishy taste.  The texture wasn't completely awful either.  :D

Ever had a double Fillet 'o Fish from the Golden Arches?  Fish at it's finest!
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Hellraiser on January 30, 2010, 01:51:56 pm
LOL no thank you!  Anyway to try and un derail this thread.  I've definitely felt like my hands and feet just aren't getting the circulation they're used to.  I don't blame the virus but my recent inactivity due to the virus.  I've just not been up to the task of going to the gym recently.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Miss Philicia on January 30, 2010, 02:13:53 pm
I still think poppers help.  I'm not sure why everyone is so dismissive about this idea.  It borders on rudeness, frankly.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Nestor on January 30, 2010, 02:14:27 pm
Quote
my hands and feet just aren't getting the circulation they're used to.

Same here---my hands are fine but my feet are always freezing! But to be fair, I think that's always been the case, and was even when I was a child, so I probably can't blame HIV for that.  But between that and the headaches I periodically have, it's pretty scary to read things like this about decreased blood flow and make the connection.  

For this reason I've been trying yoga--one of the main effects of yoga is supposed to be increased circulation.  All those inversions--shoulder-stands, head-stands--are supposed to cause blood to flow in the opposite direction from normal and therefore bring fresh blood to places where it is needed, and every pose is described as "increasing blood flow" to some particular organ or region of the body.  

I have no idea how much this helps, if at alll, but I suppose it can't hurt!  Except the ego, that is: what I'm able to do generally falls so far short of the poses described in the book....

A sauna is also said to have the effect of improving circulation.  Again, no idea if it works, but it isn't a bad thing to try!  
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Nestor on January 30, 2010, 02:21:30 pm
I've always hated the smell of poppers.  Some men whom I like a lot use poppers during sex, and so I try not to say anything bad about them.  But one friend always looks really, really scary just after using poppers: his face turns purple!  That certainly doesn't make me want to try it!

Wikipedia's page on poppers says:

Quote
Acute intake of poppers may cause asphyxia, arrhythmias, cardiovascular depression, carbon monoxide poisoning, hepatorenal toxicity, methemoglobinemia, neurologic dysfunction, mucosal, pulmonary, skin irritation and facial dermatitis. With chronic use neurological damage may occur.

I don't know what kind of use qualifies as "chronic" or how great the chances of these things are, but I don't want to find out the hard way.  
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Miss Philicia on January 30, 2010, 03:04:28 pm
But one friend always looks really, really scary just after using poppers: his face turns purple! 

Well there you go.  It's obviously an effect of increased blood circulation to the noggin'.  He'll have the last laugh when you're afflicted with AIDS dementia.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Hellraiser on January 30, 2010, 03:09:19 pm
LOL, Miss Philicia has done extensive EXTENSIVE research into poppers therapy.  Don't doubt the expert.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: veritas on January 30, 2010, 03:12:00 pm

Nestor,

You asked: " Is there a relationship between blood flow and inflammation?".

Yes there is. Acute inflamation:

http://courses.washington.edu/conj/inflammation/acuteinflam.htm

Here's another:

http://my.clevelandclinic.org/symptoms/Inflammation/hic_Inflammation_What_You_Need_To_Know.aspx

Not fun !

v
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: veritas on January 30, 2010, 03:23:32 pm

Here you go Miss P,

Everything you wanted to know about poppers in Homo-Health:

http://www.homohealth.org/mens_program/sexualhealth/poppers.htm

" Nitrates improve blood flow through blocked arteries", but........
v
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Nestor on January 30, 2010, 03:26:09 pm
Thanks Veritas!

But now I'm doubly confused.  According to those articles, increased blood flow to the brain is a feature of inflammation.  Yet the whole premise of this conversation is that blood flow is something we want, and something that HIV+ people don't get enough of.  Whereas, in many other discussions, it is inflammation that is the enemy.  

How can decreased blood flow and inflammation both be characteristics of the same condition?  

Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: veritas on January 30, 2010, 03:55:50 pm

Nestor,

Inflamation is a protective effect to remove the injured stimuli. However, blood proteins are needed to heal the wound. Without the appropriate blood flow, the wound would never heal, thus, increased blood flow is desireable. The sooner the blood gets there in the appropriate amount, the better we heal.
The inflamation is a signal to the blood to "come on down". (the relationship).

v
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Rev. Moon on January 31, 2010, 01:55:09 am
LOL...how lovely.  Guess I just don't tolerate morons too well.  Congrats for making the grade!

Was there any need for name calling and personal attacks?  You have been previously warned by Ann on how you behave around this sandbox.

Dearest Nestor, since I was the first one to bring up the subject of amyl nitrites I ask for your forgiveness.

So the bottom line is that to remain alert and avoid dementia we need to include different food groups.  The menu includes fish with back walnuts, wash it down with lots of green tea and then snort a few poppers.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: veritas on January 31, 2010, 06:09:49 am

moon,

I think you should open a restaurant  -- your menu sounds therapeutic. You could name it "Brainiac" and offer two for one popper snorts at happy hour or the never ending cup of green tea tuesdays and walnut wednesdays. Of course, fish fridays.

v
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Ann on January 31, 2010, 06:19:45 am
Freewilly,

How many times do you have to be warned about personal attacks? If you post in this thread one more time, you'll earn yourself a time out. No kidding.

Ann
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: freewillie99 on January 31, 2010, 10:36:01 am
Freewilly,

How many times do you have to be warned about personal attacks? If you post in this thread one more time, you'll earn yourself a time out. No kidding.

Ann

Whatever, Ann.  I posted an innocent comment about exercise being beneficial to blood flow and received lame sarcastic bs from a moron for my trouble.  Time out?  LMAO.  No kidding.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: skeebo1969 on January 31, 2010, 02:42:56 pm


   Why do you feel the need for your comment to be validated?  My sarcastic comment against all your trouble in that very brief post of yours was me disagreeing with you.  You taking exception to it is an issue of your own, totally out of my control just like me replying is out of your control.  You can disagree with my stance on the matter just like I disagreed with yours.  All this name calling is childish and I notice it seems to be a habit of yours here on the forum anytime someone disagrees with you.     There is an ignore feature on the left, might I suggest you use it.  That way you won't be able to see my posts and you can save yourself from the TO.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Ann on January 31, 2010, 11:00:39 pm
Whatever, Ann.  I posted an innocent comment about exercise being beneficial to blood flow and received lame sarcastic bs from a moron for my trouble.  Time out?  LMAO.  No kidding.

As you saw fit to once again call another member names, I'm giving you that time out I warned you about. Still laughing?

Ann
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: NYCguy on February 18, 2010, 03:48:21 pm
Just wanted to suggest that those who don't like Green tea try a green t latte from star bucks with sugar free syrup (any flavor).  Of course it costs a kings ransom, but tastes like heaven.

I've been taking quercetin of late and keep hearing about new benefits of it being discovered, such as anti-inflammation.  I wonder if it could have any positive impact on the brain.  I also take fish oil - another brain helper.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: GNYC09 on February 18, 2010, 10:15:43 pm
You know I just browsed over your eloquent posting history since you joined the forums.  Perhaps getting off the roids and going natural will serve you better, you seem a bit testy there.   In the mean time, go pick your next fight... who will it be?

I'll take him/her/it on!

On a more serious note, Mods, freewilly (wasn't that a dolphin movie?) has a history of trollish behavior including calling people "douchebags" (a few examples below).  Perhaps a permanent ban is in order?
http://forums.poz.com/index.php?topic=13994.msg358003#msg358003
http://forums.poz.com/index.php?topic=13994.msg357568#msg357568
http://forums.poz.com/index.php?topic=28810.msg354801#msg354801

Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: leatherman on February 18, 2010, 10:48:15 pm
Perhaps a permanent ban is in order?
they're just permanent bans now  ;)

plus, this incident happened 18 days ago. you might want to send a PM to a mod as this "discussion" is already a bit old and most people have moved on  ;)
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: red_Dragon888 on February 19, 2010, 10:19:20 am
Just wanted to suggest that those who don't like Green tea try a green t latte from star bucks with sugar free syrup (any flavor).  Of course it costs a kings ransom, but tastes like heaven.

I've been taking quercetin of late and keep hearing about new benefits of it being discovered, such as anti-inflammation.  I wonder if it could have any positive impact on the brain.  I also take fish oil - another brain helper.
Every little bit helps I say.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: freewillie99 on February 19, 2010, 03:18:53 pm
I'll take him/her/it on!

On a more serious note, Mods, freewilly (wasn't that a dolphin movie?) has a history of trollish behavior including calling people "douchebags" (a few examples below).  Perhaps a permanent ban is in order?
http://forums.poz.com/index.php?topic=13994.msg358003#msg358003
http://forums.poz.com/index.php?topic=13994.msg357568#msg357568
http://forums.poz.com/index.php?topic=28810.msg354801#msg354801



Hey, GNYC09...

Thanks for trolling, er...playing.  heh.

Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Ann on February 19, 2010, 06:11:07 pm
Hey, GNYC09...

Thanks for trolling, er...playing.  heh.



Freewilly, do you really want the permanent ban some have advocated for? After all, you have been a problem in these forums more than once. Keep it up and a ban will be arranged. Just for you. Either adjust your attitude to other forum members or be gone.

Ann
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: GNYC09 on February 19, 2010, 07:42:59 pm
Hey, GNYC09...

Thanks for trolling, er...playing.  heh.


you're funny!  :-*
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: northernguy on February 20, 2010, 01:25:17 am
I really notice the short term memory loss.  For example, last night I went out for dinner. Today had to wrack my brain for several minutes to recall where it was I had been the night before.  Stuff like that never happened a couple years ago.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Tempeboy on February 20, 2010, 02:13:53 am
This is an emerging and worrying issue, HIV gets into the brain from the point of transmission - and HIV activity in the brain can cause a range of symptoms of mood, cognition ( memory, concentration ), tremors, fatigue and isolative behaviour.

HIV Treatments improve symptoms - but not all treatments penetrate the Blood Brain Barrier effectively.
Link to further information - http://www.natap.org/2008/IAS/IAS_69.htm

Locally people are reviewing their combinations to ensure they are getting the maximum benefits in terms of 'brain penetrating HIV drugs' possible - with the fewest side effects of course.  Many of our local HIV Psychiatrists and Neurologist are suggesting low dose SSRI antidepressants for people with mild symptoms.

There are many supplements that are reported to help as well - alpha lipoic acid, green tea (if you don't like the taste it is available is supplement form) even black or white tea, omega 3's, astragalus, spriulina and others.

But exercise seems to be one of the best protectors - and cognitive enhancers - and acohol abstainence.

Now where did I put my gin?
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: Hellraiser on February 20, 2010, 01:53:34 pm
I really notice the short term memory loss.  For example, last night I went out for dinner. Today had to wrack my brain for several minutes to recall where it was I had been the night before.  Stuff like that never happened a couple years ago.

How old are you?

I was competitive in academic trivia in both high school and college, have won scholarships out of it and I've been having a lot of trouble remembering pretty basic stuff for a few years now.  I've kind of always chalked it up to I'm no longer in my early 20s so maybe I've lost my "edge", or now that I'm on Atripla it might be the mental fuzziness, or maybe I've just been out of school for so long the academic stuff isn't as readily available.  I'm definitely not as swift as I used to be however, which is a somewhat worrisome trend.
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: elf on February 21, 2010, 02:31:47 pm
In my case it's more like:

Premature Laziness in the Brain Seen in HIV Patients

 ;D
I could learn Dutch, Norwegian and improve my Spanish and English,
but I'm so lazy   ??? I only study for my exams, I think I should broaden my horizons.  :D
And I should quit Facebook :o

I hate being so lazy.  :-\
Title: Re: Premature Aging of the Brain Seen in HIV Patients
Post by: northernguy on February 21, 2010, 07:43:34 pm
How old are you?

45, so not over the hill quite yet.  ;D