moderna HIV vaccine

[Cosmicdancer]

First-in-human clinical trial confirms new HIV vaccine approach
The experimental vaccine primed the immune system as the first stage in the production of broadly neutralizing antibodies (BNABs)

A phase 1 clinical trial testing a novel vaccine approach to prevent HIV has produced promising results, IAVI and Scripps Research announced today. The vaccine showed success in stimulating production of rare immune cells needed to start the process of generating antibodies against the fast-mutating virus; the targeted response was detected in 97 percent of participants who received the vaccine.

"This study demonstrates proof of principle for a new vaccine concept for HIV, a concept that could be applied to other pathogens, as well," says William Schief, Ph.D., a professor and immunologist at Scripps Research and executive director of vaccine design at IAVI's Neutralizing Antibody Center, whose laboratory developed the vaccine. "With our many collaborators on the study team, we showed that vaccines can be designed to stimulate rare immune cells with specific properties, and this targeted stimulation can be very efficient in humans. We believe this approach will be key to making an HIV vaccine and possibly important for making vaccines against other pathogens."

Schief presented the results on behalf of the study team at the International AIDS Society HIV Research for Prevention (HIVR4P) virtual conference today.

The study sets the stage for additional clinical trials that will seek to refine and extend the approach -- with the long-term goal of creating a safe and effective HIV vaccine. As a next step, IAVI and Scripps Research are partnering with the biotechnology company Moderna to develop and test an mRNA-based vaccine that harnesses the approach to produce the same beneficial immune cells. Using mRNA technology could significantly accelerate the pace of HIV vaccine development.

HIV, which affects more than 38 million people globally, is known to be among the most difficult viruses to target with a vaccine, in large part because it constantly evolves into different strains to evade the immune system.

"These exciting findings emerge from remarkably creative, innovative science and are a testament to the research team's talent, dedication and collaborative spirit, and to the generosity of the trial participants," says Mark Feinberg, M.D., Ph.D., president and CEO of IAVI. "Given the urgent need for an HIV vaccine to rein in the global epidemic, we think these results will have broad implications for HIV vaccine researchers as they decide which scientific directions to pursue. The collaboration among individuals and institutions that made this important and exceptionally complex clinical trial so successful will be tremendously enabling to accelerate future HIV vaccine research."

The full article is here
https://www.sciencedaily.com/releases/2021/02/210203162249.htm

[em]

https://www.refinery29.com/en-us/2021/04/10406280/hiv-vaccine-moderna-antibody-response-rate

another news story well time will tell if this one pans out . I know there have been many failed attempts . but this may just be another ? maybe not ? maybe this one has promise?  just thought this might be of interest . 

[nethan1621]

Anyway this will be a shocking news for who kept Golden chicken for decades

[Almost2late]

Not sure if a successful vaccine of this type will necessarily mean therapeutic cure.. it might just be a preventive vaccine if it works.

Rollingstone also covered it like this: What the Recent HIV Vaccine Research Findings Really Mean

Over the past year, there has been a dramatic shift in the amount of space vaccines occupy in the public consciousness. During the development and testing of the current Covid-19 vaccines, people followed the different phases of the clinical trials like an early season of American Idol. In fact, many referred to and thought of it as the “race for a vaccine.” This, of course, makes sense, given that from the very start of the pandemic, public health officials made it clear that having a safe, effective vaccine was our ticket back to some type of normalcy.

Several months into the rollout, vaccines are still very much on our radar. While that truly is a win for public health, last week there was widespread confusion over clinical trial findings first made public in February. According to several dramatic headlines and exuberant, widely shared social media posts, thanks to technology developed by Moderna for their Covid-19 vaccine, a highly effective HIV vaccine is well within reach — like a modern-day public health fairytale.

Unfortunately, that didn’t happen. But some combination of misinterpreting the study’s findings, and our ongoing thirst for vaccine news, resulted in that feel-good narrative going viral. (Sorry.)

..

https://www.rollingstone.com/culture/culture-features/hiv-aids-vaccine-moderna-covid-19-1155927/amp/

It's an interesting article.

[nethan1621]

Vaccine trail approach is to generate rare anti body. Ultimately it will preventive as well as therapeutic.

https://www.arabnews.com/node/1844821/world

[Almost2late]

Vaccine trail approach is to generate rare anti body. Ultimately it will preventive as well as therapeutic.

https://www.arabnews.com/node/1844821/world

We hope so, but while most vaccines prevent and cure disease, not all do.. and HIV is one tough mf'er to cure.

Btw, that article has some inaccurate information.. for example:

... in recent years, treatments have been discovered to allow many people with HIV to live relatively normal lives, but can cost upward of $500,000 in developed countries.

While it is quite expensive in developed countries, that's a gross exaggeration. There's more but I'm not going to waist anymore time on that gobbledygook.

[nethan1621]

Let researchers to do their duty rather we jump to conclusions wether positive or negative. Anyway If it works , sorry for big pharma.

[Almost2late]

I'm sure the researchers aren't bothered by me at all.. and I wish them well bc I appreciate them.

I'm just stating a fact, therapeutic vaccines aren't common and have only been around a few years.. most vaccines are preventive.

Like I said I hope they this mRNA HIV vaccine pans out for us, but don't go betting your life savings on it.

[nethan1621]

Just wait and see... 😁

[leatherman]

While it is quite expensive in developed countries, that's a gross exaggeration.

one important issue is that this article doesn't give a time range for that $500k. At $3000 a month (over the years my meds have cost anywhere from $2500 to $3500+ a month) that's only 14 years of meds and doesn't include any testing or physician costs. I've been taking meds for 27 years. That makes this number a gross under-estimate for people who are pre-HARRT long term survivors.

[Almost2late]

one important issue is that this article doesn't give a time range for that $500k. At $3000 a month (over the years my meds have cost anywhere from $2500 to $3500+ a month) that's only 14 years of meds and doesn't include any testing or physician costs. I've been taking meds for 27 years. That makes this number a gross under-estimate for people who are pre-HARRT long term survivors.

I assumed the article was referring to yearly cost bc that's how it's usually calculated.. a lifetime will vary from person to person and you should be well over a million.

If that's the case, with only 6yrs and 4mos under my belt I'm somewhere around the $230,000 range just for meds.. and most of that coming from Obamacare (me with some taxpayer funding), ADAP (taxpayers). Since I qualify for ADAP in my new home state, I haven't paid a nickel out of pocket for meds in almost 3yrs.
Though I was asked to switch from Triumeq ($3,300) to Tivicay/Epzicom ($2000) a month.. not mandatorily, but voluntarily to cut ADAP's cost to big pharma and I happily did.

Either way, these meds are way too expensive and someone is paying for it.. Nathan is correct in that respect..

If it works , sorry for big pharma.

#MedicareForAll

[em]

someone on facebook posted this and I thought it worth passing on

https://www.youtube.com/watch?app=desktop&v=AIdOuJTASVc&fbclid=IwAR2y0cFZJK43jENvSW5fRRBdMCcArH24ysS1t_4njzSEBa3PHBG-vzyFhGU

news on a HIV Vaccine, progress 

[em]

national geographic article on HIV Vaccine

from may 3rd

https://www.nationalgeographic.com/science/article/the-four-decade-quest-for-an-hiv-vaccine-yields-new-hope?

they ask for your email to open the article.   then they say you can read three articles after entering your email then a subscription is needed  to national geographic to read any more  , just incase you might want to read this .

all the best
 EM