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Author Topic: Descovy and Orlistat Interactions  (Read 1326 times)

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Offline sydbb

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Descovy and Orlistat Interactions
« on: May 12, 2022, 10:53:41 pm »
Hello all, I have a question and hope someone has the knowledge to help me. Im currently taking Taficita(PrEP), generic version of Descovy. I just started the over the counter drug Orlistat - a medication that helps prevent the absorption of fat from food. I've done some research online, it seems that Orlistat has interactions with antiviral medications in general since Orlistat reduces the absorption of HIV drugs especially if it's lipophilic.

According to "https://www.hiv-druginteractions.org/interactions/87600", they should be taken 4-5 hours apart. But according to "https://www.webmd.com/interaction-checker/default.htm" the interaction is very serious.

Does anyone have knowledge in this subject? Theoretically do they interact if taken 4-5 hours apart? Thanks!

Offline Jim Allen

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Re: Descovy and Orlistat Interactions
« Reply #1 on: May 12, 2022, 11:11:25 pm »
Hiya,

Orlistat may theoretically reduce the absorption and therapeutic efficacy of antiretroviral agents. *

Using an interaction checker is something I recommend that people do, however, when something does flag you will need to check with your healthcare provider.

*MHRA. Medicines and Healthcare Products Regulatory Agency "Orlistat: theoretical interaction with antiretroviral HIV medicines. Available from: URL: http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON392868 " ([2014 Mar]):
« Last Edit: May 12, 2022, 11:22:41 pm by Jim Allen »
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Offline sydbb

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Re: Descovy and Orlistat Interactions
« Reply #2 on: June 02, 2022, 04:38:35 pm »
Hiya,

Orlistat may theoretically reduce the absorption and therapeutic efficacy of antiretroviral agents. *

Using an interaction checker is something I recommend that people do, however, when something does flag you will need to check with your healthcare provider.

*MHRA. Medicines and Healthcare Products Regulatory Agency "Orlistat: theoretical interaction with antiretroviral HIV medicines. Available from: URL: http://www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON392868 " ([2014 Mar]):


Thank you very much, I've asked my doctor and he said it's ok to take both at least 5 hours apart. Hopefully he's right and this doesn't effect the efficacy of PrEP, since there is no return if breakthrough infection happens.

Offline Jim Allen

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Re: Descovy and Orlistat Interactions
« Reply #3 on: June 05, 2022, 01:48:20 pm »
You're welcome.
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

 


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