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Author Topic: Dolutegravir / kidney elevation  (Read 1431 times)

0 Members and 1 Guest are viewing this topic.

Offline sanitex

  • Member
  • Posts: 485
Dolutegravir / kidney elevation
« on: March 18, 2021, 05:44:52 pm »
Hi
 What should  I do about my kidney elevation 1.66
I'm I in a danger zone at the  moment.  :😭😭😭
27/12/07 cd4 20 vl 1m
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl un
16/10/08 cd4 196 vl un
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl un 23%
24/2/12 cd4 545 vl un 26%
22/2/12 chge trv to Recovir-em.10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ml.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs testquantitative Anti-HBs pos
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 24%
24/7/14 tevir
24/9/14 cd4 517 vl <40 22%
16/3/15 cd4 545 vl  85 24%
12/4/16 cd4 626 vl <40 25%
16/8/16 cd4 396 vl <40 27% changNVP/recovir-em 22/7
8/12/16 cd4 511 vl ud 23%
5/6/16 cd4 688 vl ud %27
17/9 /20  chng TLD

Offline Almost2late

  • Member
  • Posts: 1,371
Re: Dolutegravir / kidney elevation
« Reply #1 on: March 18, 2021, 09:45:49 pm »
1.66 is high.. I'm no doctor but if I were you, I'd see my doctor again, get retested and ask him about it.. until then I'd keep myself well hydrated and lay off alcohol, caffeine and smoking.

You might see a better result after retesting.. and it may not be your treatment causing it.

I had high creatinine level but it was due to the truvada TDF and was switched off it. I still take dolutegravir.

Talk to doc.

Offline sanitex

  • Member
  • Posts: 485
Re: Dolutegravir / kidney elevation
« Reply #2 on: March 18, 2021, 11:53:04 pm »
Thanks for the advice  but I don't  drink alcohol much like that but I took lemon with hot water every morning  I don't  if its the cause .. is like  I'm having  BP of 140 / 90 ups and down .
27/12/07 cd4 20 vl 1m
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl un
16/10/08 cd4 196 vl un
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl un 23%
24/2/12 cd4 545 vl un 26%
22/2/12 chge trv to Recovir-em.10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ml.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs testquantitative Anti-HBs pos
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 24%
24/7/14 tevir
24/9/14 cd4 517 vl <40 22%
16/3/15 cd4 545 vl  85 24%
12/4/16 cd4 626 vl <40 25%
16/8/16 cd4 396 vl <40 27% changNVP/recovir-em 22/7
8/12/16 cd4 511 vl ud 23%
5/6/16 cd4 688 vl ud %27
17/9 /20  chng TLD

Offline spikey

  • Member
  • Posts: 13
Re: Dolutegravir / kidney elevation
« Reply #3 on: March 20, 2021, 10:29:19 am »

Thanks for the advice  but I don't  drink alcohol much like that but I took lemon with hot water every morning  I don't  if its the cause .. is like  I'm having  BP of 140 / 90 ups and down .

Consume adequate amount of liquid and stay off strenuous workout few days prior to the test. I tanked my creatinine level last time (160) and it was caused by working out too hard at the gym. I had to to another round of test and result returned to normal range again.

18-01-16-DX
24-02-16 CD4 104 VL 1.04 M
25-02-16 Prophylaxis
09-03-16 COMBIVIR+SUSTIVA
11-08-16 CD4 335 VL 53
24-10-16 COMBIVIR+TIVICAY
10-01-17 TRUVADA +TIVICAY
00-02-17 CD4 336 VL -UD
08-01-18 CD4 667 VL -UD
04-06-18 CD4 705 VL
06-08-18 TIVICAY+DESCOVY
17-06-19 CD4 740

Offline sanitex

  • Member
  • Posts: 485
Re: Dolutegravir / kidney elevation
« Reply #4 on: March 22, 2021, 12:12:38 pm »
Consume adequate amount of liquid and stay off strenuous workout few days prior to the test. I tanked my creatinine level last time (160) and it was caused by working out too hard at the gym. I had to to another round of test and result returned to normal range again.
Thanks  for the advice,
But I'm suspecting my viral load might  rebounds to detectable   I rechecked my kidney today 1.7 last week was 1.66 all different  hospitals  .I think  I'll try  not to do exercise before doing another  test
27/12/07 cd4 20 vl 1m
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl un
16/10/08 cd4 196 vl un
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl un 23%
24/2/12 cd4 545 vl un 26%
22/2/12 chge trv to Recovir-em.10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ml.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs testquantitative Anti-HBs pos
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 24%
24/7/14 tevir
24/9/14 cd4 517 vl <40 22%
16/3/15 cd4 545 vl  85 24%
12/4/16 cd4 626 vl <40 25%
16/8/16 cd4 396 vl <40 27% changNVP/recovir-em 22/7
8/12/16 cd4 511 vl ud 23%
5/6/16 cd4 688 vl ud %27
17/9 /20  chng TLD

Offline sanitex

  • Member
  • Posts: 485
Re: Dolutegravir / kidney elevation
« Reply #5 on: March 22, 2021, 12:14:16 pm »
Pls someone should  help me on what to do either  to recheck  my cd4 and viral  load  ..
27/12/07 cd4 20 vl 1m
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl un
16/10/08 cd4 196 vl un
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl un 23%
24/2/12 cd4 545 vl un 26%
22/2/12 chge trv to Recovir-em.10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ml.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs testquantitative Anti-HBs pos
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 24%
24/7/14 tevir
24/9/14 cd4 517 vl <40 22%
16/3/15 cd4 545 vl  85 24%
12/4/16 cd4 626 vl <40 25%
16/8/16 cd4 396 vl <40 27% changNVP/recovir-em 22/7
8/12/16 cd4 511 vl ud 23%
5/6/16 cd4 688 vl ud %27
17/9 /20  chng TLD

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 17,220
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: Dolutegravir / kidney elevation
« Reply #6 on: March 22, 2021, 12:38:35 pm »
Hiya.

Why would you need to recheck CD4 and Viral Load? When was it last checked and was there an issue?

Regarding the serum creatinine level of 1.66, have you spoken to your doctor? I think the advice to make sure you are drinking healthy amounts can't hurt. Maybe you could retest this to see what's what in a few weeks depending on what the doc says.
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline sanitex

  • Member
  • Posts: 485
Re: Dolutegravir / kidney elevation
« Reply #7 on: March 22, 2021, 01:17:17 pm »


Why would you need to recheck CD4 and Viral Load? When was it last checked and was there an issue?

Regarding the serum creatinine level of 1.66, have you spoken to your doctor? I think the advice to make sure you are drinking healthy amounts can't hurt. Maybe you could retest this to see what's what in a few weeks depending on what the doc says.


My last viral test was june last year and it was undetectable before I changed  to TLD on September last year ..
I test for kidney last week  with another  clinic it was 1.66 that was fasting  test then  today I rest  with another  clinic without fasting  from another  hospital  the result came  out 1.7 and  I took  almost 1 litter of water before  testing  .
27/12/07 cd4 20 vl 1m
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl un
16/10/08 cd4 196 vl un
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl un 23%
24/2/12 cd4 545 vl un 26%
22/2/12 chge trv to Recovir-em.10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ml.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs testquantitative Anti-HBs pos
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 24%
24/7/14 tevir
24/9/14 cd4 517 vl <40 22%
16/3/15 cd4 545 vl  85 24%
12/4/16 cd4 626 vl <40 25%
16/8/16 cd4 396 vl <40 27% changNVP/recovir-em 22/7
8/12/16 cd4 511 vl ud 23%
5/6/16 cd4 688 vl ud %27
17/9 /20  chng TLD

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 17,220
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: Dolutegravir / kidney elevation
« Reply #8 on: March 22, 2021, 01:27:55 pm »
And in Sept last year, you were already 1.5 correct?

If I was you I would drink plenty of fluids, talk to your doctor about this and getting a VL done as it's been nearly 9 months and you have not checked since switching.

You are on TDF 300 mg, 3TC 300 mg, and DTG 50 mg. - i.e TLD? Maybe its time to switch away from anything with TDF but that's something to discuss with the doctor.
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline sanitex

  • Member
  • Posts: 485
Re: Dolutegravir / kidney elevation
« Reply #9 on: March 22, 2021, 11:49:20 pm »
I was with heart doctor  yesterday after evaluation and echocardiogram and Ecg he told  me that I have enlarged heart due to untreated BP for almost a year plus  that it's  the cuase of my creatine increase. In short I'm  confused. He pressed me on arbitel-Am 40 and tothema also doppel herz ..
 However in Nigeria I don't think they have different options like Thailand as per to change TDF.
Pls which one  is better  than TDF
27/12/07 cd4 20 vl 1m
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl un
16/10/08 cd4 196 vl un
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl un 23%
24/2/12 cd4 545 vl un 26%
22/2/12 chge trv to Recovir-em.10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ml.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs testquantitative Anti-HBs pos
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 24%
24/7/14 tevir
24/9/14 cd4 517 vl <40 22%
16/3/15 cd4 545 vl  85 24%
12/4/16 cd4 626 vl <40 25%
16/8/16 cd4 396 vl <40 27% changNVP/recovir-em 22/7
8/12/16 cd4 511 vl ud 23%
5/6/16 cd4 688 vl ud %27
17/9 /20  chng TLD

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 17,220
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: Dolutegravir / kidney elevation
« Reply #10 on: March 23, 2021, 12:08:04 am »
So the heart doctor started you on treatment for the BP and they feel that could be the cause.

When do you next see your HIV clinic/doctor?

HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline sanitex

  • Member
  • Posts: 485
Re: Dolutegravir / kidney elevation
« Reply #11 on: March 23, 2021, 07:00:52 am »
My hiv doctor  said they will switch me to abacavir lamivudine and dolutegravir.
How's  abacavir reaction is good to switch bcoz there's no other option again.
27/12/07 cd4 20 vl 1m
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl un
16/10/08 cd4 196 vl un
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl un 23%
24/2/12 cd4 545 vl un 26%
22/2/12 chge trv to Recovir-em.10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ml.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs testquantitative Anti-HBs pos
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 24%
24/7/14 tevir
24/9/14 cd4 517 vl <40 22%
16/3/15 cd4 545 vl  85 24%
12/4/16 cd4 626 vl <40 25%
16/8/16 cd4 396 vl <40 27% changNVP/recovir-em 22/7
8/12/16 cd4 511 vl ud 23%
5/6/16 cd4 688 vl ud %27
17/9 /20  chng TLD

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 17,220
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: Dolutegravir / kidney elevation
« Reply #12 on: March 23, 2021, 08:53:07 am »
My hiv doctor  said they will switch me to abacavir lamivudine and dolutegravir.
How's  abacavir reaction is good to switch bcoz there's no other option again.

As fixed-dose (single pill)? If you could get 3TC & DTG as separate pills that might be an option as well.

Anyhow, ABC/3TC and DTG is the same combo I take, my own experience is fine. 2 of the components you already take, it's just the ABC is new for you.

Try it and see how you get on.
 
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline sanitex

  • Member
  • Posts: 485
Re: Dolutegravir / kidney elevation
« Reply #13 on: March 23, 2021, 04:38:39 pm »
My ID doctor later changed his mind  and told me to wait for another  month before switching to single dose  of (ziagen) he want me  to retest again  by a month and test my viral load  tomorrow.
27/12/07 cd4 20 vl 1m
10/4 /08 cd4 86 vl 63
1/7/08  cd4 186 vl un
16/10/08 cd4 196 vl un
23/1/09 cd4 248 vl un
10/9/11 cd4 418 vl <40 %22
13/12/11 cd4 410 vl un 23%
24/2/12 cd4 545 vl un 26%
22/2/12 chge trv to Recovir-em.10/9/11 cd4 418 vl <40 %22
7/7/12 cd4 359 vl <40 22%
23/8/12 cd4 400 vl <40 23%,
testosterone test 7.5 ng/ml and
thyroid (TSH)1.32 ml.
13/12/2012 cd4 523 24% vl <40
18/3/2013 cd4  513  23% vl <40
03/8/2013 cd4 429 22% vl <40
13/11/2013 cd4 455 23% vl <40
Anti-HBs testquantitative Anti-HBs pos
Titer 16.95 mlu/ml <10.00
22/3/14 cd4 396 vl <40 24%
24/7/14 tevir
24/9/14 cd4 517 vl <40 22%
16/3/15 cd4 545 vl  85 24%
12/4/16 cd4 626 vl <40 25%
16/8/16 cd4 396 vl <40 27% changNVP/recovir-em 22/7
8/12/16 cd4 511 vl ud 23%
5/6/16 cd4 688 vl ud %27
17/9 /20  chng TLD

 


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