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Author Topic: Bloody diarrhea, sepsis, Shigella and poor absorption ARV  (Read 840 times)

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Offline multifan

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  • Posts: 14
Bloody diarrhea, sepsis, Shigella and poor absorption ARV
« on: February 26, 2021, 03:01:42 pm »
A three weeks ago I was hospitalized due to fever, sepsis (E. coli), Procalcitonin 2.2, bloody diarrhea (10 times per day) and Shigella infection. My CRP was 500. I didn't eat anything. Diarrhea disappears after 9 days when I got TMP/SMX. I was discharged from the hospital after two weeks with CRP 10 and low hemoglobin count 10.9. I think I could develop resistance due to poor absorption of my ARV. I took all of my ARV, even I took 2 pills extra at night during the first week.
When should I perform the VL test? I found a lab where it costs just 80USD and I don't need any reference. I'll get a result in three days. I can't stop thinking about resistance and change my meds to the worser ones. I can't work and think about anything else. I don't want to perform VL screening too early after severe inflammation, because it could elevate my VL count itself.
One pill of Triumeq daily is the best option for me. Earlier, my adherence was 100 percent. Is two weeks enough time from last diarrhea to perform VL screening? I think only it can calm me down. Currently, I can't contact my ID doc. When my ID performs VL screening, I have to wait for the result for two months.

Thank you for any advice.
« Last Edit: February 26, 2021, 03:14:50 pm by multifan »
OI - CNS Toxoplasmosis, oral candidiasis
17/05/2018  CD4 - 27  VL 188.000 Dexamethasone i.v., Sulfadiazine 2x3g, Daraprim 75mg, Leucovorin 15mg 1xd, Azithromycinum 1xweek 600mg
31/05/2018  start Triumeq
21/06/2018  discharge from hospital
08/07/2018  CD4 - 124  VL 37 Sulfadiazine 1.5g2xd, Daraprim 50mg 1xd, discontinue Azithromycinum
14/08/2018  CD4 - 110 11%
10/10/2018  CD4 -  94  9% 
16/10/2018  CD4 - 154 VL <20
16/11/2018  CD4 - 180 VL<20
20/01/2019 CD4 140 VL<20
29/06/2019 CD4 220 VL <20 13%
29/08/2019 CD4 180  13%
25/09/2019 CD4 220  14%  CD4/CD8 0.31 discontinued Daraprim/Sulfadiazine
18/05/2020 CD4 220 12%
21/08/2020 VL - 39, Chlamydia Trachomatis
08/01/2021 CD4 240 13% CD4/CD8 0.4
03/03/2021 CD4 280 14% CD4/CD8 0.3 VL<40

Online Jim Allen

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Re: Bloody diarrhea, sepsis, Shigella and poor absorption ARV
« Reply #1 on: February 26, 2021, 03:15:04 pm »
Sorry to hear you have been feeling unwell and hope you are starting to feel better.

Truimeg, If it was me and I've been through illness myself, including 10 days off meds,  I would just continue to take my meds as normal now, not stress about it and get my VL done whenever next normally due.

When is your next regular VL test due?
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline multifan

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  • Posts: 14
Re: Bloody diarrhea, sepsis, Shigella and poor absorption ARV
« Reply #2 on: February 26, 2021, 03:33:59 pm »
Thanks, now I feel much better.
I just continue to take my meds as normal now, but I can't stop stress about my VL.
Due to Covid-19 issue, there are no appointments, my ID doc performs a VL test yearly, the last one was in September. When I perform CD4 screening myself, I simply send it to my doc. My UD status is very important for me.
OI - CNS Toxoplasmosis, oral candidiasis
17/05/2018  CD4 - 27  VL 188.000 Dexamethasone i.v., Sulfadiazine 2x3g, Daraprim 75mg, Leucovorin 15mg 1xd, Azithromycinum 1xweek 600mg
31/05/2018  start Triumeq
21/06/2018  discharge from hospital
08/07/2018  CD4 - 124  VL 37 Sulfadiazine 1.5g2xd, Daraprim 50mg 1xd, discontinue Azithromycinum
14/08/2018  CD4 - 110 11%
10/10/2018  CD4 -  94  9% 
16/10/2018  CD4 - 154 VL <20
16/11/2018  CD4 - 180 VL<20
20/01/2019 CD4 140 VL<20
29/06/2019 CD4 220 VL <20 13%
29/08/2019 CD4 180  13%
25/09/2019 CD4 220  14%  CD4/CD8 0.31 discontinued Daraprim/Sulfadiazine
18/05/2020 CD4 220 12%
21/08/2020 VL - 39, Chlamydia Trachomatis
08/01/2021 CD4 240 13% CD4/CD8 0.4
03/03/2021 CD4 280 14% CD4/CD8 0.3 VL<40

Online Jim Allen

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  • Member
  • Posts: 17,201
  • Twitter @JimAllenDublin
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Re: Bloody diarrhea, sepsis, Shigella and poor absorption ARV
« Reply #3 on: February 26, 2021, 03:42:34 pm »
Well glad to hear that you are feeling better  :)

To be honest self CD4 testing is a bit of a waste, anyhow, glad my reply helped.

Quote
but I can't stop stress about my VL.

Look if it is causing that much undue stress and it's not a burden go ahead and get the VL test for peace of mind. Give it two weeks and test otherwise relax and wait for next appointment in sept.
« Last Edit: February 26, 2021, 03:44:57 pm by Jim Allen »
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline multifan

  • Member
  • Posts: 14
Re: Bloody diarrhea, sepsis, Shigella and poor absorption ARV
« Reply #4 on: February 26, 2021, 04:18:33 pm »
I don't think my CD4 screenings are performed too often. I did it because I thought about vaccinating against HepB, and good CD4 count is important for it.
Medical care in Poland is not at the high level, fortunately it is free, I don't pay anything for my HIV meds. My ID has much work with COVID-19 patients, so she has to cancel appointments with HIV patients,only urgent cases are possible.
Now, I can't stop stressing about my VL, so a good result will certainly calm me down, and a bad result will speed up the appointment with my ID.
If two weeks are enough, I'll do it next week.
« Last Edit: February 26, 2021, 04:22:45 pm by multifan »
OI - CNS Toxoplasmosis, oral candidiasis
17/05/2018  CD4 - 27  VL 188.000 Dexamethasone i.v., Sulfadiazine 2x3g, Daraprim 75mg, Leucovorin 15mg 1xd, Azithromycinum 1xweek 600mg
31/05/2018  start Triumeq
21/06/2018  discharge from hospital
08/07/2018  CD4 - 124  VL 37 Sulfadiazine 1.5g2xd, Daraprim 50mg 1xd, discontinue Azithromycinum
14/08/2018  CD4 - 110 11%
10/10/2018  CD4 -  94  9% 
16/10/2018  CD4 - 154 VL <20
16/11/2018  CD4 - 180 VL<20
20/01/2019 CD4 140 VL<20
29/06/2019 CD4 220 VL <20 13%
29/08/2019 CD4 180  13%
25/09/2019 CD4 220  14%  CD4/CD8 0.31 discontinued Daraprim/Sulfadiazine
18/05/2020 CD4 220 12%
21/08/2020 VL - 39, Chlamydia Trachomatis
08/01/2021 CD4 240 13% CD4/CD8 0.4
03/03/2021 CD4 280 14% CD4/CD8 0.3 VL<40

Offline multifan

  • Member
  • Posts: 14
Re: Bloody diarrhea, sepsis, Shigella and poor absorption ARV
« Reply #5 on: March 03, 2021, 03:38:27 pm »
Today, I performed HIV-1 RNA quantity screening, and I got the result the same day, after just 7 hours. The test was a low-cost, rapid Real-Time PCR GeneXpert, with sensitivity <40copies/ml. This kind of test allows the lab to perform only one test at the same time. They don't have to wait for samples from a few patients. My doc performs tests with sensitivity <20 copies/ml, so she has to wait a few weeks for a result.

My result is <40 copies/ul, my CD4 count raises to 280, so I'm more than happy, it calmed me down. It gave me a peace of mind. I'm waiting only for the Shigella screening, but it doesn't stress me at all.
« Last Edit: March 03, 2021, 03:42:19 pm by multifan »
OI - CNS Toxoplasmosis, oral candidiasis
17/05/2018  CD4 - 27  VL 188.000 Dexamethasone i.v., Sulfadiazine 2x3g, Daraprim 75mg, Leucovorin 15mg 1xd, Azithromycinum 1xweek 600mg
31/05/2018  start Triumeq
21/06/2018  discharge from hospital
08/07/2018  CD4 - 124  VL 37 Sulfadiazine 1.5g2xd, Daraprim 50mg 1xd, discontinue Azithromycinum
14/08/2018  CD4 - 110 11%
10/10/2018  CD4 -  94  9% 
16/10/2018  CD4 - 154 VL <20
16/11/2018  CD4 - 180 VL<20
20/01/2019 CD4 140 VL<20
29/06/2019 CD4 220 VL <20 13%
29/08/2019 CD4 180  13%
25/09/2019 CD4 220  14%  CD4/CD8 0.31 discontinued Daraprim/Sulfadiazine
18/05/2020 CD4 220 12%
21/08/2020 VL - 39, Chlamydia Trachomatis
08/01/2021 CD4 240 13% CD4/CD8 0.4
03/03/2021 CD4 280 14% CD4/CD8 0.3 VL<40

 


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