Bienvenido(a), Visitante. Por favor, ingresa o regístrate.
Febrero 28, 2024, 02:01:50 am

Ingresar con nombre de usuario, contraseña y duración de la sesión


Usuarios
  • Total de Usuarios: 37566
  • Latest: zhegal
Stats
  • Total de Mensajes: 772602
  • Total de Temas: 66269
  • Online Today: 256
  • Online Ever: 5484
  • (Junio 18, 2021, 11:15:29 pm)
Usuarios en Línea
Users: 0
Guests: 206
Total: 206

Bienvenido


Bienvenido a los Foros Comunitarios de POZ, un área de discusión contínua para personas con VIH/SIDA, sus amigos/familiares/personas que los cuidan, y otros a quienes les interese el tema del VIH/SIDA. Haz clic en los enlaces que siguen para visitar nuestros foros, o participa de la conversación al inscribirte en el sector izquierdo de esta página.

To change forums navigation language settings, click here(Members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí(Sólo miembros), Regístrate ahora

Advertencia sobre la privacidad: Ten en cuenta que estos foros están abiertos para todos y que se los puede encontrar haciendo búsquedas en Google u otros buscadores. Si eres VIH positivo y lo revelas en nuestros foros, es lo mismo que decírselo al mundo entero (o al menos al mundo entero en Internet). Si esto te preocupa, no uses un nombre de usuario o una imagen gráfica que pueda identificarte de alguna manera. No autorizamos borrar nada de los que escribas en los foros, por lo tanto piensa antes de hacerlo.

  • La información que los moderadores y miembros comparten en estos foros, está diseñada para complementar, y no para reemplazar la relación entre un individuo y su médico de cabecera.

  • Todos los miembros de estos foros, en consecuencia, no son considerados proveedores médicos con licencia. De lo contrario, los usuarios deben identificarse a sí mismos como tales.

  • Los miembros de los foros siempre deben comportarse con respeto y honestidad. La publicación de guías, incluyendo políticas de suspensiones y prohibiciones han sido establecidas por los moderadores de estos foros. Haga clic aquí para las guías de publicación de “¿Estoy infectado?” Haga clic aquí para leer las guías de publicación relacionadas con todos los otros foros comunitarios de POZ.

  • Solicitamos a todos los miembros de los foros que proporcionen referencias sobre la información relacionada con la salud/médica/científica que brinden, cuando no se trate de una experiencia personal que estén compartiendo. Por favor proporcionen enlaces con direcciones de Internet completas o citas completas de trabajos publicados que no estén disponibles en Internet. Además, todos los miembros de los foros deben publicar información que sea verdadera y correcta de acuerdo con su conocimiento.

  • Los anuncios de productos – incluyendo enlaces, banderas, contenido editorial y estudios clínicos, estudios o participación en encuestas – está estrictamente prohibido por los miembros de los foros a menos que POZ haya asegurado el permiso.

¿Has terminado de leer esta parte? Puedes cerrar esta o cualquier otra ventana en esta página haciendo click en el símbolo de cada ventana.

Autor Tema: moderna HIV vaccine  (Leído 8807 veces)

0 Usuarios y 1 Visitante están viendo este tema.

Desconectado Cosmicdancer

  • Member
  • Mensajes: 199
moderna HIV vaccine
« en: Marzo 14, 2021, 11:34:49 am »
First-in-human clinical trial confirms new HIV vaccine approach
The experimental vaccine primed the immune system as the first stage in the production of broadly neutralizing antibodies (BNABs)

A phase 1 clinical trial testing a novel vaccine approach to prevent HIV has produced promising results, IAVI and Scripps Research announced today. The vaccine showed success in stimulating production of rare immune cells needed to start the process of generating antibodies against the fast-mutating virus; the targeted response was detected in 97 percent of participants who received the vaccine.

"This study demonstrates proof of principle for a new vaccine concept for HIV, a concept that could be applied to other pathogens, as well," says William Schief, Ph.D., a professor and immunologist at Scripps Research and executive director of vaccine design at IAVI's Neutralizing Antibody Center, whose laboratory developed the vaccine. "With our many collaborators on the study team, we showed that vaccines can be designed to stimulate rare immune cells with specific properties, and this targeted stimulation can be very efficient in humans. We believe this approach will be key to making an HIV vaccine and possibly important for making vaccines against other pathogens."

Schief presented the results on behalf of the study team at the International AIDS Society HIV Research for Prevention (HIVR4P) virtual conference today.

The study sets the stage for additional clinical trials that will seek to refine and extend the approach -- with the long-term goal of creating a safe and effective HIV vaccine. As a next step, IAVI and Scripps Research are partnering with the biotechnology company Moderna to develop and test an mRNA-based vaccine that harnesses the approach to produce the same beneficial immune cells. Using mRNA technology could significantly accelerate the pace of HIV vaccine development.

HIV, which affects more than 38 million people globally, is known to be among the most difficult viruses to target with a vaccine, in large part because it constantly evolves into different strains to evade the immune system.

"These exciting findings emerge from remarkably creative, innovative science and are a testament to the research team's talent, dedication and collaborative spirit, and to the generosity of the trial participants," says Mark Feinberg, M.D., Ph.D., president and CEO of IAVI. "Given the urgent need for an HIV vaccine to rein in the global epidemic, we think these results will have broad implications for HIV vaccine researchers as they decide which scientific directions to pursue. The collaboration among individuals and institutions that made this important and exceptionally complex clinical trial so successful will be tremendously enabling to accelerate future HIV vaccine research."

The full article is here
https://www.sciencedaily.com/releases/2021/02/210203162249.htm
Summer, 2007 - &$#@?
November, 2007 - Tested poz, 300,000 vl, 560 cd4
Feb, 2008 - 57,000 vl, 520 cd4, started Atripla
2/2008 - 5/2015 - undetectable on Atripla
May, 2015 - UD, switched to Complera
September, 2015 - UD, 980 cd4, switched to Stribild (Complera interacted with acid reflux medication)
January, 2016 - Stribild, UD, 950 cd4
June, 2016 - UD, 929 cd4

Desconectado em

  • Member
  • Mensajes: 688
Re: moderna HIV vaccine
« Respuesta #1 en: Abril 08, 2021, 04:46:01 am »
https://www.refinery29.com/en-us/2021/04/10406280/hiv-vaccine-moderna-antibody-response-rate

another news story well time will tell if this one pans out . I know there have been many failed attempts . but this may just be another ? maybe not ? maybe this one has promise?  just thought this might be of interest . 

Desconectado nethan1621

  • Member
  • Mensajes: 48
Re: moderna HIV vaccine
« Respuesta #2 en: Abril 09, 2021, 05:47:05 pm »
Anyway this will be a shocking news for who kept Golden chicken for decades

Desconectado Almost2late

  • Member
  • Mensajes: 1,447
Re: moderna HIV vaccine
« Respuesta #3 en: Abril 17, 2021, 01:56:50 pm »
Not sure if a successful vaccine of this type will necessarily mean therapeutic cure.. it might just be a preventive vaccine if it works.

Rollingstone also covered it like this: What the Recent HIV Vaccine Research Findings Really Mean
Citar
Over the past year, there has been a dramatic shift in the amount of space vaccines occupy in the public consciousness. During the development and testing of the current Covid-19 vaccines, people followed the different phases of the clinical trials like an early season of American Idol. In fact, many referred to and thought of it as the “race for a vaccine.” This, of course, makes sense, given that from the very start of the pandemic, public health officials made it clear that having a safe, effective vaccine was our ticket back to some type of normalcy.

Several months into the rollout, vaccines are still very much on our radar. While that truly is a win for public health, last week there was widespread confusion over clinical trial findings first made public in February. According to several dramatic headlines and exuberant, widely shared social media posts, thanks to technology developed by Moderna for their Covid-19 vaccine, a highly effective HIV vaccine is well within reach — like a modern-day public health fairytale.

Unfortunately, that didn’t happen. But some combination of misinterpreting the study’s findings, and our ongoing thirst for vaccine news, resulted in that feel-good narrative going viral. (Sorry.)
..

https://www.rollingstone.com/culture/culture-features/hiv-aids-vaccine-moderna-covid-19-1155927/amp/

It's an interesting article.




Desconectado nethan1621

  • Member
  • Mensajes: 48
Re: moderna HIV vaccine
« Respuesta #4 en: Abril 18, 2021, 06:01:25 pm »
Vaccine trail approach is to generate rare anti body. Ultimately it will preventive as well as therapeutic.

https://www.arabnews.com/node/1844821/world

Desconectado Almost2late

  • Member
  • Mensajes: 1,447
Re: moderna HIV vaccine
« Respuesta #5 en: Abril 18, 2021, 06:53:50 pm »
Vaccine trail approach is to generate rare anti body. Ultimately it will preventive as well as therapeutic.

https://www.arabnews.com/node/1844821/world
We hope so, but while most vaccines prevent and cure disease, not all do.. and HIV is one tough mf'er to cure.

Btw, that article has some inaccurate information.. for example:
Citar
... in recent years, treatments have been discovered to allow many people with HIV to live relatively normal lives, but can cost upward of $500,000 in developed countries.

While it is quite expensive in developed countries, that's a gross exaggeration. There's more but I'm not going to waist anymore time on that gobbledygook.

Desconectado nethan1621

  • Member
  • Mensajes: 48
Re: moderna HIV vaccine
« Respuesta #6 en: Abril 18, 2021, 07:09:11 pm »
Let researchers to do their duty rather we jump to conclusions wether positive or negative. Anyway If it works , sorry for big pharma.

Desconectado Almost2late

  • Member
  • Mensajes: 1,447
Re: moderna HIV vaccine
« Respuesta #7 en: Abril 18, 2021, 07:25:15 pm »
I'm sure the researchers aren't bothered by me at all.. and I wish them well bc I appreciate them.

I'm just stating a fact, therapeutic vaccines aren't common and have only been around a few years.. most vaccines are preventive.

Like I said I hope they this mRNA HIV vaccine pans out for us, but don't go betting your life savings on it.


Desconectado nethan1621

  • Member
  • Mensajes: 48
Re: moderna HIV vaccine
« Respuesta #8 en: Abril 19, 2021, 06:14:16 am »
Just wait and see... 😁

Desconectado leatherman

  • Global Moderator
  • Member
  • Mensajes: 8,571
  • Google and HIV meds are Your Friends
Re: moderna HIV vaccine
« Respuesta #9 en: Abril 19, 2021, 06:26:49 am »
While it is quite expensive in developed countries, that's a gross exaggeration.
one important issue is that this article doesn't give a time range for that $500k. At $3000 a month (over the years my meds have cost anywhere from $2500 to $3500+ a month) that's only 14 years of meds and doesn't include any testing or physician costs. I've been taking meds for 27 years. That makes this number a gross under-estimate for people who are pre-HARRT long term survivors.
leatherman (aka Michael)

We were standing all alone
You were leaning in to speak to me
Acting like a mover shaker
Dancing to Madonna then you kissed me
And I think about it all the time
- Darren Hayes, "Chained to You"

Desconectado Almost2late

  • Member
  • Mensajes: 1,447
Re: moderna HIV vaccine
« Respuesta #10 en: Abril 19, 2021, 01:18:02 pm »
one important issue is that this article doesn't give a time range for that $500k. At $3000 a month (over the years my meds have cost anywhere from $2500 to $3500+ a month) that's only 14 years of meds and doesn't include any testing or physician costs. I've been taking meds for 27 years. That makes this number a gross under-estimate for people who are pre-HARRT long term survivors.
I assumed the article was referring to yearly cost bc that's how it's usually calculated.. a lifetime will vary from person to person and you should be well over a million.

If that's the case, with only 6yrs and 4mos under my belt I'm somewhere around the $230,000 range just for meds.. and most of that coming from Obamacare (me with some taxpayer funding), ADAP (taxpayers). Since I qualify for ADAP in my new home state, I haven't paid a nickel out of pocket for meds in almost 3yrs.
Though I was asked to switch from Triumeq ($3,300) to Tivicay/Epzicom ($2000) a month.. not mandatorily, but voluntarily to cut ADAP's cost to big pharma and I happily did.

Either way, these meds are way too expensive and someone is paying for it.. Nathan is correct in that respect..
If it works , sorry for big pharma.

#MedicareForAll

« última modificación: Abril 19, 2021, 01:22:48 pm por Almost2late »

Desconectado em

  • Member
  • Mensajes: 688
Re: moderna HIV vaccine
« Respuesta #11 en: Mayo 04, 2021, 03:42:14 pm »
someone on facebook posted this and I thought it worth passing on

https://www.youtube.com/watch?app=desktop&v=AIdOuJTASVc&fbclid=IwAR2y0cFZJK43jENvSW5fRRBdMCcArH24ysS1t_4njzSEBa3PHBG-vzyFhGU

news on a HIV Vaccine, progress 

Desconectado em

  • Member
  • Mensajes: 688
Re: moderna HIV vaccine
« Respuesta #12 en: Mayo 04, 2021, 03:48:26 pm »
national geographic article on HIV Vaccine

from may 3rd

https://www.nationalgeographic.com/science/article/the-four-decade-quest-for-an-hiv-vaccine-yields-new-hope?

they ask for your email to open the article.   then they say you can read three articles after entering your email then a subscription is needed  to national geographic to read any more  , just incase you might want to read this .

all the best
 EM 
« última modificación: Mayo 04, 2021, 03:55:23 pm por em »

 


Terms of Membership for these forums
 

© 2024 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.