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Author Topic: A Novel Class of HIV-1 Antiviral Agents  (Read 2367 times)

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Offline Mishma

  • Member
  • Posts: 234
  • HIV drugs are our Allies but hardly our Friends
    • Marquis de Vauban
A Novel Class of HIV-1 Antiviral Agents
« on: December 08, 2015, 11:41:50 am »
http://www.nature.com/articles/srep17808


A Novel Class of HIV-1 Antiviral Agents Targeting HIV via a SUMOylation-Dependent Mechanism
Ikenna G. Madu, Shirley Li, Baozong Li, Haitang Li, Tammy Chang, Yi-Jia Li, Ramir Vega, John Rossi, Jiing-Kuan Yee, John Zaia & Yuan Chen

We have recently identified a chemotype of small ubiquitin-like modifier (SUMO)-specific protease (SENP) inhibitors. Prior to the discovery of their SENP inhibitory activity, these compounds were found to inhibit HIV replication, but with an unknown mechanism. In this study, we investigated the mechanism of how these compounds inhibit HIV-1. We found that they do not affect HIV-1 viral production, but significantly inhibited the infectivity of the virus. Interestingly, virions produced from cells treated with these compounds could gain entry and carry out reverse transcription, but could not efficiently integrate into the host genome. This phenotype is different from the virus produced from cells treated with the class of anti-HIV-1 agents that inhibit HIV protease. Upon removal of the SUMO modification sites in the HIV-1 integrase, the compound no longer alters viral infectivity, indicating that the effect is related to SUMOylation of the HIV integrase. This study identifies a novel mechanism for inhibiting HIV-1 integration and a new class of small molecules that inhibits HIV-1 via such mechanism that may contribute a new strategy for cure of HIV-1 by inhibiting the production of infectious virions upon activation from latency.

Another potential ally in our fight for treatment and a cure. Given that many HIV +
s under treatment are non-compliant due to drug toxicities and or side effects, we desperately need new drugs that are better tolerated. This is one such drug.
2016 CD4 25% UD (less than 20). 30+ years positive. Dolutegravir, Acyclovir, Clonazepam, Lisinopril, Quetiapine, Sumatriptan/Naproxen, Restasis, Latanoprost, Asprin, Levothyroxine, Restasis, Triamcinolone.

Offline TigerPoz

  • Member
  • Posts: 11
Re: A Novel Class of HIV-1 Antiviral Agents
« Reply #1 on: December 08, 2015, 07:07:55 pm »
Wow - sounds like a potential break through !!! Going to be interesting to Follow!
Best regards,

TigerPoz
2013-03-01: HIV Negative
2013-06-09:HIVRNA 540487 CD4+:320 CD8+:230
- started Atripla
2013-06-19:HIVRNA 118971 CD4+:640 CD8+:430
2013-07-10:HIVRNA    1175 CD4+:710 CD8+:480
2013-08-05:HIVRNA       31 CD4+:740 CD8+:400
2013-09-11:HIVRNA       98 CD4+:940 CD8+:930
2013-11-05:HIVRNA       UD CD4+:1000CD8+:1000 changed to Stribild
2013-12-04: HIVRNA      UD CD4+: 990 CD8+:880

Offline tryingtostay

  • Member
  • Posts: 591
Re: A Novel Class of HIV-1 Antiviral Agents
« Reply #2 on: December 10, 2015, 12:41:38 am »
Very interesting, thanks for sharing :)

 


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