ICCARE Project - short intra weekly cycles study

[puxcca]

Hey guys,

Quick question: has anyone heard about the ICCARE Project?
They published a study on the efficacy of intermittent treatment...

Four Days a Week or Less on Appropriate Anti HIV Drug Combinations Provided Long Term Optimal Maintenance in 94 Patients. The ICCARRE* PROJECT
http://www.valas.fr/IMG/pdf/the_iccarre_project_leibowitch_et_al_re-edited_ms_29_dec_2014.pdf

Their website (french): http://www.association-iccarre.org

[zach]

Sounds like the FOTO strategy.

Are you HIV+? Considering participating?

[Giancarlo]

It is indeed the same as FOTO.
I talked briefly about ICCARE here, a few years ago:
http://forums.poz.com/index.php?topic=50418.msg609686#msg609686

Now, things have changed a bit as a clinical trial has started: https://clinicaltrials.gov/ct2/show/NCT02157311?term=ANRS+162+4D&rank=1
I think the study is still ongoing, although the previous link says it has been completed. I haven't seen any communication about its results anyway.

In the meantime, my (French) doc doesn't want to hear about it...

[zach]

i've said this before a few times, and am reminded of it every time this kind of information comes up again

i wish i had known about strategies like FOTO when i was initially diagnosed and put on atripla. it overwhelmed me, at a time i didn't know to question how i was being medicated. i didn't cope well at all, and ended up abandoning treatment. out of ignorance, i didn't seek another solution. that was one of the greatest mistakes of my life. physically i've never fully come back from the second fight with AIDS.

but i found this board, and started learning. now i realize there are many different solutions to the riddle.

[Giancarlo]

Now, things have changed a bit as a clinical trial has started: https://clinicaltrials.gov/ct2/show/NCT02157311?term=ANRS+162+4D&rank=1
I think the study is still ongoing, although the previous link says it has been completed. I haven't seen any communication about its results anyway.

Some (promising) results of the ANRS-4D trial have been presented today at AIDS2016 in Durban.
Among the 100 patients who started a 4 days a week regimen, 96 still had a viral load below 50 copies/mL after 48 weeks, 1 quit the trial because she went pregnant, and 3 had a detectable viral load at weeks 4, 12, and 40 (respectively, 785, 124, and 969 copies/mL), but with a drop of the viral load below the detection threshold upon return to the 7 days a week treatment regimen, without appearance of resistance.
http://www.eurekalert.org/pub_releases/2016-07/a-sca071816.php

Next steps: a randomized trial comparing two groups of patient (ANRS QUATUOR), which is expected to start at the end of the year.

[Giancarlo]

Just found out that you can download the e-poster on the AIDS2016 conference website:
http://programme.aids2016.org/PAGMaterial/eposters/0_5947.pdf