JTT-705 for low cholesterol

[ZCorker]

What ever happened to JTT-705?  This is drug is supposed raise HDL Cholesterol (good cholesterol).  The last I heard, Roche was looking for investigators and was asking Heart Doctors and Endocrinologist to sign up on Roche's website.

Has anyone heard what is going on with this?  Different than Pfizer, Roche has decided not exclude hiv patients from the study.  Clinicians interested in participating can sign up on the website can sign up at

https://www.rocheinvestigators.com/

 

[veritas]

Latest research I could find:


http://www.curehunter.com/public/pubmed18789492.do


 INTRODUCTION: While elevated plasma HDL levels are inversely correlated with cardiovascular events, raising HDL with the CETP inhibitor torcetrapib, however, was associated with increased cardiovascular morbidity and mortality in the ILLUMINATE trial. Whether the deleterious clinical effects of torcetrapib represent a molecule specific off-target effect, a class effect of CETP inhibitors or both is matter of ongoing debate. As such, the aim of the present study was to investigate whether CETP-inhibition with JTT-705, a molecule distinctly different from torcetrapib, impacts on vascular function, a well-established surrogate of atherosclerotic vascular disease, as well as markers of inflammation and oxidative stress in patients with type II hyperlipidemia. METHODS AND RESULTS: Eighteen patients were randomized to receive JTT-705 600 mg/d or matching placebo for 4 weeks. Flow-mediated dilation (FMD) was measured using ultrasonography of the brachial artery. HDL-C increased by 26% from 1.14 mmol/l to 1.44 mmol/l (p=0.01) in the JTT-705 group, while triglycerides decreased from 2.52 mmol/l to 1.97 mmol/l (p=0.03). CETP- inhibition with JTT-705, however, did not change FMD (3.1+/-0.6% to 3.6+/-0.4%; p=0.48). Interestingly, in a sub group analysis of patients with lower than median HDL-C (<1.19 mmol/l), FMD increased by 41% in patients vs. patients with higher than median HDL-C (>1.19 mmol/l; p=0.01). Markers of vascular inflammation (CRP, ICAM-1, IL-6, TNF alpha), as well as plasma endothelin-1 levels all remained unchanged throughout the study. CONCLUSION: In patients with type II hyperlipidemia, CETP inhibition with JTT-705 increased HDL-C and lowered triglycerides but improved endothelial function in the subgroup of patients with low baseline HDL-C levels only.
Authors Frank Hermann, Frank Enseleit, Lukas E Spieker, Daniel Périat, Isabella Sudano, Matthias Hermann, Roberto Corti, Georg Noll, Frank Ruschitzka, Thomas F Lüscher
Journal Thrombosis research (Thromb Res) Vol. 123 Issue 3 Pg. 460-5 ( 2009) ISSN: 0049-3848 United States
PMID 18789492 (Publication Type: Journal Article) 

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