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Author Topic: A Question For The Triumeq Takers  (Read 2281 times)

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Offline daveR

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A Question For The Triumeq Takers
« on: November 11, 2021, 07:55:27 am »
Hello,
I have been on a two pill regime equivalent to Triumeq for seven weeks. I was switched from Complera to Biktarvy to Triumeq due to high serum creatinine levels. For the first 3 weeks everything was OK but since then I have been slowly going down hill. I expected some settling in period as it is three new drugs for me but things are getting worse.
Currently I have no energy, get out of breath walking about 750 meters, headaches, sensitive skin round the abdomen and lower back, and now coughing. I checked the Triumeq web site for the symptoms of an adverse reaction and they seem very generic. I have no rash or stomach pains but some of my issues are listed.

My question is, did anybody else taking Triumeq experience these symptoms, if so at what time frame? I shall address these with my health care provider tomorrow probably, not going to wait till March but a heads up from board members who may have experienced the same would be good.

I take it in the mornings, tried with food and without, no difference. I feel sick about 30 minutes after taking it. I also did not have the specific test to check for possible reactions prior to starting. My Dr just said take it and see how you go.

Thanks
Dave
« Last Edit: November 11, 2021, 08:05:47 am by daveR »

Offline Jim Allen

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Re: A Question For The Triumeq Takers
« Reply #1 on: November 11, 2021, 08:09:46 am »
Hiya,

No issues with Triumeq myself, except the sleep but morning dosing resolved that. Hypersensitivity was checked before I started treatment.

Anyhow, hope you feel better soon. Keep us posted.
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Offline kentfrat1783

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Re: A Question For The Triumeq Takers
« Reply #2 on: November 11, 2021, 08:24:48 am »
Hi,

I've been on Triumeq for just over 2 years and I haven't had any issues.  Proior to that I was on Atripla and had the typical side effects with that.   

Just work with your healthcare provider and see if it's due to the new Rx or if something else is going on.

Wishing you the best. 

Kenneth
10/12/2022 - CD4 316 (19%) VL <20
06/20/2022 - CD4 292 (21%) VL <20
01/25/2022 - CD4 321 (22%) VL <20
09/22/2021 - CD4 278 (19%) VL <20
02/02/2021 - CD4 225 (19%) VL <20
06/08/2020 - CD4 257 (20%) VL <20
03/17/2020 - CD4 285 (19%) VL 101       (2.00)
12/17/2019 - CD4 290 (20%) VL <20
09/17/2019 - CD4 218 (16%)
06/18/2019 - CD4 173 (16%) VL <20
03/13/2019 - CD4 170 (16%) VL <20
January 2019 - Started Triumeq
12/05/2108 - CD4 174 (18%) VL <20
08/28/2018 - CD4 166 (15%) VL <20
05/08/2018 - CD4 106 (11%) VL <20
03/05/2018 - CD4   90 (10%) VL <20
12/11/2017 - CD4   60 (  8%)
09/07/2017 - CD4   42 (  6%) VL  54        (1.70)
May 2017 - Started Atripla
05/11/2017 - CD4     2 (  1%) VL 169,969 (5.23)
OI's: PCP
Dx`d May 11, 2017
Location: USA

Offline Grendal

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Re: A Question For The Triumeq Takers
« Reply #3 on: November 11, 2021, 12:03:16 pm »
Triumeq failed me, put me into rhabdomylosis. My symptoms were rather unlike yours except the no energy part. Now doing ok with Genvoya. You’ll likely need to switch meds.

Offline daveR

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Re: A Question For The Triumeq Takers
« Reply #4 on: November 16, 2021, 01:16:02 am »
Finally got to see my Dr today. She assured me it is not hyper sensitivity to the Abacavir. She suspects the culprit is the Dolutegravir. Offered to change it for Edurant but I turned it down. I will continue and see what develops. Switch from taking it in the morning to lunch time with a larger meal. Possible the full stomach may take away the nausea. May just be a case of needing some time to let the body adjust to the new meds.

Offline daveR

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Re: A Question For The Triumeq Takers
« Reply #5 on: November 21, 2021, 10:43:09 pm »
All is well now, it seems that by pure coincidence I developed a touch of Bronchitis after I had been on the new meds for 4 weeks. Coughing, tightness in the chest and trouble breathing were nothing to do with the Triumeq. Just bad timing. The stomach is settling down, headaches have gone. Changed my routine a bit to fit the pills in, it is now breakfast, workout and then meds instead of taking the meds straight after breakfast and before working out. I believe this is helping with the nausea I was suffering.
My creatinine is now below the maximum threshold so hopefully I can stick with Triumeq for a few years.

Dave

Offline Mindless

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Re: A Question For The Triumeq Takers
« Reply #6 on: December 18, 2021, 12:14:04 am »
Hi Dave,

I'm sorry,  I had no idea you went through all this hassle with ARVs. I thought you were still on Biktarvy as we discussed last year or dso. I'm not much on the forum lately. Sorry to hear that Biktarvy didn't work for you but very good that you found an alternative.

I'm still on Dovato (DTG+Lamivudine) and didn't have big side effects apart from the first few weeks.  I was on generic Complera as you. My creatinine are at the higher threshold too, my Dr suggested a wait and see approach but yes, I'm a bit worried.

Take care!




Offline daveR

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Re: A Question For The Triumeq Takers
« Reply #7 on: December 18, 2021, 01:27:22 am »
Hi Mindless,
No problem. I was only on Biktarvy for a short while as it did not have the desired effect. Creatinine increased but I think the Dr jumped the gun. It is a pity as it was a good pill, small with no food requirements and only one pill. Now I am back to two pills as the single pill Triumeq is expensive at my hospital.
I am happy to say everything has settled down with it now, no issues. Good to see you have also found a stable regime after your earlier start. I had my Creatinine levels checked after a couple of months and they are back to normal after over 5 years of being a bit high. So no damage done. Getting off the Tenonfivir regime was a good thing to do.

Offline Shazam9cd4

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Re: A Question For The Triumeq Takers
« Reply #8 on: November 12, 2022, 08:32:38 am »
A question on this post regarding High creatinine.  I am also on Triumeq and  seem to be handling quite well.  I was diagnosed in May, taking triumeq since, and am also on Septrim prophylaxis due to very low CD4 nadir and only recently getting above 100.

Most of my blood work is with in normal range - The only issues being a steadily  rising cretinine (over last 6months 108,118 and now 124). And low GFR (58, 62 and now 54).  I am assuming this is the septrim because ive heard triumeq has little negative impact on the kidneys - mosty on the heart. 

Were you on any other drugs which may impact kidneys?   I had also been on PRoton Pump Inhibitors which are also k own to cause kidney issues. 

Thanks!

Offline daveR

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Re: A Question For The Triumeq Takers
« Reply #9 on: November 13, 2022, 08:24:36 am »
A question on this post regarding High creatinine.  I am also on Triumeq and  seem to be handling quite well.  I was diagnosed in May, taking triumeq since, and am also on Septrim prophylaxis due to very low CD4 nadir and only recently getting above 100.

Most of my blood work is with in normal range - The only issues being a steadily  rising cretinine (over last 6months 108,118 and now 124). And low GFR (58, 62 and now 54).  I am assuming this is the septrim because ive heard triumeq has little negative impact on the kidneys - mosty on the heart. 

Were you on any other drugs which may impact kidneys?   I had also been on PRoton Pump Inhibitors which are also k own to cause kidney issues. 

Thanks!

My Creatinine levels were slightly high because of my first regime, Complera. They increased slowly over a few years but were relatively stable 1.24-1.3. The switch to Triumeq did seem to cause a temporary decrease as I had a reading in normal range but it is back up to 1.24 again. I take no other medication so I am certain it was the TDF, damage is done. Kidney unction was always good prior to starting ARV's.
My Dr assures me that Triumeq has no effect on kidneys and so far they are not getting worse. From what I have read, although over 1.18 is out of range at my hospital, levels up to 1.3 are nothing to worry about and even slightly higher is OK. 

Consult your health care provider, if your HIV Dr is different from your normal health care provider just make sure they know about all of the medication you take, even some over the counter drugs from a pharmacy can impact the kidneys.

Offline Shazam9cd4

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Re: A Question For The Triumeq Takers
« Reply #10 on: November 27, 2022, 08:26:02 pm »
Hi Dave.  I suspect the culprit is my prophylactic course of Septrim.  But thats not a given.  I have been exercising and working out at increasing kevels since i ealked out of hospital and this could impact creatine levels so this weeks when i get my next set of tests done ill refrain from any seeious exertion for at least 48 hours before.  Docs arent too worried at this stage as max creatine is 1.24 but they want to watch the steadily increasing level. 

Other than that i have no other symptoms (headache, nausea, diahhrea etc) outside sensitive itchy skin which has been improving.  All other blood work moved within normal range post hospital (except cd4 and lymphocytes).   Hoping this weeks test will show stabalized kidney function, increased CD4 above 200 and UD viral load both for first time.  Fingers crossed.  Once stabilised docs want to switch me from triumeq to dovato,  and from crestor to lipitor (not sure why as crestor seems to be the  better cholesterol reducer?)

 


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