Welcome, Guest. Please login or register.
December 08, 2021, 02:02:39 am

Login with username, password and session length


Members
Stats
  • Total Posts: 762751
  • Total Topics: 64813
  • Online Today: 90
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 1
Guests: 82
Total: 83

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Maturation inhibitors?  (Read 471 times)

0 Members and 1 Guest are viewing this topic.

Offline CircularNatural

  • Member
  • Posts: 29
  • 🇦🇷 Joined Sept 2021
Maturation inhibitors?
« on: October 19, 2021, 02:17:15 pm »
As a sidenote, after my diagnosis (Aug 2021) my ID doctor offered me that if I wanted to he could refer me to an experimental trial going on here in Argentina regarding a newer drug belonging to the "Maturation inhibitor" class.
I was really anxious at that time (I needed certainties) so I asked to start treatment with generic Dovato (dolutegravir + lamivudine) instead (which I'm currently happy with, even though I've just started a month and a half ago).

I feel curious about this new class of drugs, though.

Does anybody have any information on maturation inhibitors or newer meds?

Big hugs to all
🇦🇷 "Hope is the only thing stronger than fear."

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 18,038
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: Maturation inhibitors?
« Reply #1 on: October 19, 2021, 02:32:01 pm »
Would that offer have been GSK3640254? There have been a few over the years but I think this one was the most recent.

https://www.poz.com/article/early-studies-hiv-maturation-inhibitor-shows-safe-tolerable (2019) Early Studies of HIV Maturation Inhibitor Shows Itís Safe and Tolerable

https://www.medpagetoday.com/meetingcoverage/croi/91572 (2021)
Maturation Inhibitor Shows Promise for HIV ó Encouragement from phase II study, but emergent resistance remains a problem

I don't think off the top of my head there are any Maturation Inhibitor HIV treatments in general use though. Few attempts over the last decade+ I know that, but happy to be corrected though if anyone knows an approved Maturation Inhibitor for HIV treatment?

There is this cheat sheet with a list of treatments.
https://www.poz.com/drug_charts/hiv-medications

Might split this into its own topic, still debating it with myself.

HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline CircularNatural

  • Member
  • Posts: 29
  • 🇦🇷 Joined Sept 2021
Re: Maturation inhibitors?
« Reply #2 on: October 19, 2021, 02:37:31 pm »
Yeah, that sounds probable (GSK3640254), since the article says that it's for people new to ARVs
It'll be interesting to follow this up :)
🇦🇷 "Hope is the only thing stronger than fear."

Offline CircularNatural

  • Member
  • Posts: 29
  • 🇦🇷 Joined Sept 2021
Re: Maturation inhibitors?
« Reply #3 on: October 19, 2021, 03:10:53 pm »
I'm glad I said no, though, since I also just read that there were reports of drug resistances and that it had to go paired with other 2 NNRTIs, so I'd rather stay with my current Dovato treatment (I haven't had a check-up after starting, though)
🇦🇷 "Hope is the only thing stronger than fear."

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 18,038
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: Maturation inhibitors?
« Reply #4 on: October 20, 2021, 07:43:52 am »
So as a note, I split the above posts into a new topic on "Maturation inhibitors"

The original topic can be found here: https://forums.poz.com/index.php?topic=75669.0 Dolutegravir Trumps Other HIV Meds in Cutting Viral Load
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline harleymc

  • Member
  • Posts: 1,450
Re: Maturation inhibitors?
« Reply #5 on: November 04, 2021, 03:36:54 am »
Sometimes I adore having failing eyesight. 


I misread the post title as "masturbation inhibitors"...

 


Terms of Membership for these forums
 

© 2021 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.