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Meds, Mind, Body & Benefits => Nutrition & HIV => Topic started by: bimazek on January 31, 2007, 02:45:34 am
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treatment interruption - use vitamin E study says
on: January 29, 2007, 06:40:42 PM
vitamin E supplementation may interfere with the emergence of drug-resistant HIV-1 variants archived in the resting cell reservoir and delay or limit virus rebound upon treatment interruptions.
: AIDS. 2005 May 20;19
In vitro suppression of latent HIV-1 activation by vitamin E: potential clinical implications.
* Heredia A,
* Davis C,
* Amoroso A,
* Taylor G,
* Le N,
* Bamba D,
* Redfield RR.
Division of Clinical Research, Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, MD, USA.
We evaluated the effect of vitamin E in controlling HIV-1 production upon activation of the patients' reservoir of resting CD4 lymphocytes in tissue culture experiments. The addition of vitamin E to patients' cultures resulted in significantly reduced levels of p24 virus production (P = 0.0015). These results suggest that vitamin E supplementation may interfere with the emergence of drug-resistant HIV-1 variants archived in the resting cell reservoir and delay or limit virus rebound upon treatment interruptions.
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Administration of vitamin E suppresses CD95L mRNA expression and protects T cells of HIV-1-infected individuals from CD95-mediated apoptosis.
Our data suggest that the survival and differentiation of HIV-specific CD8(+) T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells.
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