Welcome, Guest. Please login or register.
March 28, 2024, 10:29:57 am

Login with username, password and session length


Members
Stats
  • Total Posts: 772945
  • Total Topics: 66310
  • Online Today: 379
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 2
Guests: 350
Total: 352

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Future of Atripla  (Read 2159 times)

0 Members and 1 Guest are viewing this topic.

Offline Nowandthen301

  • Member
  • Posts: 7
Future of Atripla
« on: January 21, 2017, 04:17:43 pm »
I am seeing a lot of posts about newer drugs being recommended over Atripla due to side effects.  I am also seeing post about this drugs effectivity when taking as little as three days a week.

Being that the drug will go off patent relatively soon am I correct to assume it potentially will provide the biggest return for the cost some point in the future?

Are researchers looking at lower doses for people who have remained undetectable for a certain period of time rather than taking the higher dose less frequently?  I assume this lower dose would reduce side effects?  Would this lower dose cause the drug's patent to be extended in the US?

Finally why are treatment cost not more often part of the discussion?  I understand insurance covers most cost, but that only raises the price society pays for insurance and incentives drug companies to charge more (rightly or wrongly).

Sorry for all the loaded questions!

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 22,262
  • Threads: @jim16309
    • Social Media: Threads
Re: Future of Atripla
« Reply #1 on: January 21, 2017, 04:32:10 pm »
Hi

There are a number of drugs that have patents dropping including Truvada soon enough.

As for Atripla yeah its not routinely recommend as first choice anymore, there are more effective treatments for people and less side effects that said if your on Atripla and happy that is cool for you.

Quote
Are researchers looking at lower doses for people who have remained undetectable for a certain period of time rather than taking the higher dose less frequently?  I assume this lower dose would reduce side effects?  Would this lower dose cause the drug's patent to be extended in the US?

There are plenty of studies into bi therapy and even mono therapy ongoing with more modern meds, I suspect that the mid term future is down the bi therapy  route, fewer side effects to start with and lower dosages, with more targeted modern drugs rather than looking at the older combinations and cutting the days.

SWORD Study - Tivicay (dolutegravir) and Edurant (rilpivirine)
GEMINI trial - dual therapy with dolutegravir plus lamivudine

That said it has been looked at:
https://www.poz.com/article/may-possible-take-atripla-just-three-times-week

Cost of treatment is often a discussion, be it separate from the discussion of side effects etc.  Generic drugs and the switch to them for example is something often discussed when talking about PrEP. I suppose it all depends who your talking to.

On the forum we have a few threads about the costs and also costs of generic drugs as part of the insurance & benefits topic https://forums.poz.com/index.php?board=27.0 Feel free to read and/or open a thread in that section if you want to talk about the costs.
 
Jim
« Last Edit: January 21, 2017, 04:42:16 pm by JimDublin »
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

My Instagram
Threads

Offline eric48

  • Standard
  • Member
  • Posts: 1,361
Re: Future of Atripla
« Reply #2 on: January 22, 2017, 12:02:19 pm »
Are researchers looking at lower doses for people who have remained undetectable for a certain period of time rather than taking the higher dose less frequently? 

Yes... WHO has approved EFV 400 mg; hence Cipla has annouced a replacement pill, currently known as TLE-400

(Tenofovir/Lamivudine/Evafirenz 400 mg)

the press release is here:
http://www.prnewswire.com/news-releases/on-world-aids-day-mylan-announces-plans-to-be-the-first-to-market-newly-recommended-antiretroviral-treatment-for-99-per-patient-per-year-300186205.html

Will it be available every where ? I doudt so, but we will see. Since the press relaese, I haven't found anything new.

Alternatively to dosage reduction, there has been a few trials using the standard 600mg with less frequent dosing; in the US the strategy is named FOTO and is detailed here: (BTW, I am using it, but not with Efavirenz found in Atripla)

http://crine.org/our-research/research-network/foto/

For the other trials, you will have to google somewhat.
NVP/ABC/3TC/... UD ; CD4 > 900; CD4/CD8 ~ 1.5   stock : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: https://clinicaltrials.gov/ct2/show/NCT02157311 ; 2016: use of granted patent US9101633, 3 days ON, 4days OFF; 2017: added TDF, so NVP/TDF/ABC/3TC, once weekly

 


Terms of Membership for these forums
 

© 2024 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.