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Author Topic: Tivicay  (Read 50668 times)

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Offline Cluffmasta

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  • Posts: 22
Tivicay
« on: August 27, 2013, 01:06:05 pm »
I start Tivicay tonight and was wondering if anyone has started this new drug as well? Side effects are suppose to be minimal which i'm looking forward to, switching from Isentress.

Offline Ann

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Re: Tivicay
« Reply #1 on: August 28, 2013, 04:34:45 am »
Hi Cluff, welcome to the forums!

Tivicay is the brand-name of the much-awaited dolutegravir. As far as I know, you're the first person to be prescribe this new med in these forums. Congrats!

A lot of people are very excited about this med - it's slated to become Sustiva's replacement as a preferred first-line treatment. Without the Sustiva side-effects. (It's also not in the same class as Sustiva.)

It would be great if you kept this thread updated to let us know how it goes. Thanks!

http://www.gsk.com/media/press-releases/2013/viiv-healthcare-announces-u-s--approval-of-tivicay---dolutegravi.html

Ann

PS - what other meds are you on? Truvada? Kivexa?
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Nymphomaniac: a woman as obsessed with sex as an average man. Mignon McLaughlin

HIV is certainly character-building. It's made me see all of the shallow things we cling to, like ego and vanity. Of course, I'd rather have a few more T-cells and a little less character. Randy Shilts

Offline Cluffmasta

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Re: Tivicay
« Reply #2 on: August 28, 2013, 12:34:21 pm »
Thanks for your reply Ann. My Dr. said I'm the first patient to try it in the clinic other than her patients she has had in a clinical trial. I have taken Truvada and Isentress for about 4 1/2 years, switched to Stribild in June 2013 - not a good pill for me. I have been back on the Truvada and Isentress for about two weeks again and remember why I wanted to switch, terrible headaches and diarrhea. My labs are good - VL undetectable  CD4 - 700 CD4% - 49 The side effects have just been the unpleasant part.

So we will see how the Tivicay works, hoping for the best! Took it last night around 10pm and so far it seems to be just fine! My Dr. said to expect a little nausea the first week until my body adjusts to it. There is a little nausea present but nothing to complain about. All I can say so far is SO FAR SO GOOD!

Offline Miss Philicia

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Re: Tivicay
« Reply #3 on: August 28, 2013, 01:07:37 pm »
I see my doctor on Sept. 10th and mostly likely will be switching from Isentress to Tivicay as this plan was previously discussed with him several appointments ago. I'll let you know when/if it happens.
"I’ve slept with enough men to know that I’m not gay"

Offline surf18

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Re: Tivicay
« Reply #4 on: August 29, 2013, 01:58:14 pm »
Yep  I have appointment next week. I'll be switching too.
Keep us up to date

Offline Jeff G

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Re: Tivicay
« Reply #5 on: August 29, 2013, 02:16:56 pm »
You youngsters with your newfangled HIV meds ... when I first got pozzed up we only had AZT and took a 180 of them before noon and liked it .

Im looking forward to updates , thinking about changing myself . 
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Offline Miss Philicia

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Re: Tivicay
« Reply #6 on: August 29, 2013, 05:01:49 pm »
I am not young and I also took AZT. I'm making this switch for a couple good clinical reasons and fully encouraged to do so by my physician, thankuverymuch. I will be able to reduce my current HIV regimen from 7 pills per day taken twice daily, half with food restrictions to two pills once daily with no pill restrictions. Furthermore he expects me to either greatly reduce or eliminate my need for 12 pills daily for diarrhea side effects. Anyway, going from 19 pills to 2 sounds like a pretty good reason both as a patient and the cost to the taxpayer (though I'll still be taking pills for other bullshit: lyrica, diovan, prescription vit. d etc.)
"I’ve slept with enough men to know that I’m not gay"

Offline the4realone

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Re: Tivicay
« Reply #7 on: August 30, 2013, 04:24:27 pm »
I was subscribed Tivicay as well Cluffmasta ---- I got it yesterday along with Epzicom ---- my doctors were waiting for it to be approved for me because of chronic kidney disease --- I did not take it yet ... this will be my first time beginning treatment --- my diagnosis was on January 1, 2013 --- and doctors believe I was just infected late summer early fall last year due to acute sero-conversion and the fact that when I was tested in November 2012 while in hospital test came back negative

Well I will be starting, if not tonight then certainly before next weekend --- been getting some good encouragement ... concerned about what side effects will be especially since I already deal with some for other meds I am taking for other health conditions ... wishing you the best

Offline mikeyb39

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Re: Tivicay
« Reply #8 on: September 03, 2013, 06:56:21 pm »
I take isentress now and I wonder if it is what is causing my headaches or migraines if you will.  Does anyone think this new drug will make any difference in that?   its in the same class category. 

Anyone else feel the isentress causes you actual headaches.  I get bad migraines from time to time, it seems more frequent when I switched meds a year or so ago.
11/02/2010  cd4-251, vl-591000
12/09/2010  started Atripla
02/18/2011  cd4-425, vl-800
06/10/2011  cd4-447, vl-70
10/10/2011  cd4-666, vl-80
01/05/2012  swiched med (prezista,norvir ,isentress, )
02/10/2012  cd4-733, vl-UD  Viread removed
06/10/2012  cd4-614, vl-UD
12/14/2012  cd4-764, vl-UD
09/01/2013  cd4-785, vl-UD
03/06/2014. cd4- 1078, VL-UD
09/05/2014  cd4-850 , VL-UD
09/05/2014 switched meds isentress, prezcobix -still only two antivirals
10/14/2015  cd4-600 , VL-UD

Offline Cluffmasta

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  • Posts: 22
Re: Tivicay
« Reply #9 on: September 03, 2013, 07:58:34 pm »
  Anyone else feel the isentress causes you actual headaches.  I get bad migraines from time to time, it seems more frequent when I switched meds a year or so ago.
When I take Isentress it gives me terrible headaches! My Dr. switched me to Stribild in June, headaches went away but it gave me terrible anxiety. I had to switch back to Truvada and Isentress for two weeks and my headaches returned, luckily my Dr. was able to get the Tivicay relatively quick for me. I have been on Tivicay now for 7 days and while I still get a little head pressure it is nothing like the Isentress caused  :)

Offline the4realone

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Re: Tivicay
« Reply #10 on: September 05, 2013, 06:33:17 pm »
Tonight September 5, 2013 @6:15pm goes down in history as the first night that I took ARV's/ART ... I did wait as I wanted until I got my most recent lab results ... they came in this morning and made the final decision to begin this evening ... keep me in your prayers it was a major step For ME ... I will keep you all updated on how it goes and is going --- 1 Tivicay and 1 Epzicom daily

Offline surf18

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Re: Tivicay
« Reply #11 on: September 05, 2013, 07:12:54 pm »
I have to wait. My insurance does not cover it yet.

Offline GoForIt

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  • Posts: 214
Re: Tivicay
« Reply #12 on: September 06, 2013, 06:25:33 pm »
Please post more information about any side-effects or feelings while being on Tivicay.

I am going to be also starting Tivicay and Epzicom as soon as my labs come back that confirm I am not allergic to the Epzicom.

While Tivicay sounds like the latest and greatest medication to be on, there is almost no actual reviews or patient comments about it which makes me slightly anxious to know how others are feeling while taking Tivicay. 

I hope that it is working great for you and would really appreciate to hear more from you and your thoughts on Tivicay.

Thanks.
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline Cluffmasta

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  • Posts: 22
Re: Tivicay
« Reply #13 on: September 06, 2013, 07:34:52 pm »
I hope that it is working great for you and would really appreciate to hear more from you and your thoughts on Tivicay.

I have now been on the Tivicay for about 12 days now! The first two to three day I had a hard time sleeping but I went from taking my daily meds in the morning to starting them at night. I take truvada and Tivicay right before I go to bed now, around 10pm. I think my body was just adjusting to taking the medications at night, now I sleep just fine. The only side effect I have noticed is a little head pressure, I wouldn't even call it a headache! The Isentress gave me terrible headaches and the Tivicay has yet to do what the Isentress caused. So far being on the Truvada and Tivicay has been the best regimen I have been on.  :D

Offline GoForIt

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Re: Tivicay
« Reply #14 on: September 07, 2013, 02:29:19 pm »
That is good news to hear.  Thanks for replying so quick.

I was just diagnosed in early August and have probably been living poz for the last 3-4 years without knowing.  My T-Cells are 506 and VL is about 10,500 according to my first test.  I also just got re-tested to make sure there was no false positive or at least establish some kind of base-line idea, which I am waiting for the results of.

I have not started any treatment yet but my doctor recommended Tivicay over Atripla.  Originally he was going to start me on Tivicay and Truvada but then he read that Tivicay will be coming in a combined pill very soon of Tivicay/Epzicom (because its made by the same company).  This is why he is starting me on these two so that once its in the one pill form it will be easier to adhere to.  He also informed me that Tivicay has almost no side-effects in comparison to Atripla's common rash/nightmares/drunk feeling/and empty stomach requirement. 

So it SOUNDS like Tivicay is a much nicer option to have instead of the Atripla but I would really like to hear more about your day-by-day experience with Tivicay as I will be starting also very soon.  Anyone else who is taking Tivicay or Epzicom I  would also like to hear from too.  Thanks!
« Last Edit: September 07, 2013, 02:31:21 pm by GoForIt »
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline GoForIt

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  • Posts: 214
Re: Tivicay
« Reply #15 on: September 07, 2013, 02:31:45 pm »
This post was made by mistake but I can't figure out how to remove it.  Was trying to quote you on my original post but it reposted....bleh
« Last Edit: September 07, 2013, 02:34:57 pm by GoForIt »
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline the4realone

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  • Posts: 16
Re: Tivicay
« Reply #16 on: September 10, 2013, 07:26:59 am »
Tivicay and Epzicom Honestly it is going very well for me ... my first night or two some crazy dreams which made me jump up with anxiety and disoriented BUT I don't believe it was the meds but rather brought on by my phobia and anxiety about taking the meds ... Now I am dealing with some insomnia sleeping for like 3-4 Hours at night and then up for 3-4 before I can go back to sleep but even if that is one of the side effects .... hey those are minimal to me .... none of the other things that I feared at all .... I take at 6pm every evening and enjoy my evening right up to going to bed with absolutely no problems at all ... I do get dry pasty mouth at night and through the day ... I just keep me some water and mints or something close to my bed and when out and about ... Again though, not sure it is even from Tivicay and Epzicom because I am on a number of other meds as well .... So my final word is I give them KUDOS for this pairing especially for me who have never been on ART before now.

Offline Matts

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Re: Tivicay
« Reply #17 on: September 12, 2013, 10:52:16 am »
DLG should be the first choice  for first-line therapy, because it's quite resistant against mutations- says a Canadian study:

"Conclusions
Our findings suggest that DTG may be intrinsically resistant to the emergence of resistance and that this drug should be used in first-line therapy to minimize the emergence of possible drug resistance. The finding that a secondary mutation, i.e. H51Y, may simultaneously reduce viral replication and enzymatic activity, while augmenting levels of drug resistance in the presence of a primary resistance mutation, i.e. R263K, could potentially be advantageous not only for HIV treatment but for strategies aimed at HIV eradication as well.....

One caveat of the above arguments is that viruses that fail to achieve integration will not help us to deal with the problem of the HIV reservoir in individuals previously infected by HIV, even if such subjects have been treated with drugs such as DTG. However, it is possible that the withholding of all anti-HIV drugs from treated subjects might result in an activation of latent viruses from reservoirs. In this context, viruses that fail to achieve efficient integration, such as those decribed here, might fail to effectively repopulate reservoirs and multiple cycles of on/off therapy might diminish the size of the latent reservoir over time. While awaiting the results of further clinical studies involving DTG, these are concepts that could be studied in animal models. "

http://www.retrovirology.com/content/10/1/22



Dovato

Offline GoForIt

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Re: Tivicay
« Reply #18 on: September 12, 2013, 11:29:20 am »
DLG should be the first choice  for first-line therapy, because it's quite resistant against mutations- says a Canadian study:

One caveat of the above arguments is that viruses that fail to achieve integration will not help us to deal with the problem of the HIV reservoir in individuals previously infected by HIV, even if such subjects have been treated with drugs such as DTG. However, it is possible that the withholding of all anti-HIV drugs from treated subjects might result in an activation of latent viruses from reservoirs. In this context, viruses that fail to achieve efficient integration, such as those decribed here, might fail to effectively repopulate reservoirs and multiple cycles of on/off therapy might diminish the size of the latent reservoir over time. While awaiting the results of further clinical studies involving DTG, these are concepts that could be studied in animal models. "

http://www.retrovirology.com/content/10/1/22

What does this mean exactly?  Does this mean that it could be bad to use this drug because you may need to activate those reservoir viruses later on?  A little confused about that second paragraph.
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline Matts

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Re: Tivicay
« Reply #19 on: September 12, 2013, 02:51:40 pm »
You can forget the second paragraph- It's about a trial in monkeys to eradicate HIV with DLG and two special mutations. Its very complicated- I dont understand it fully so far.
There are two known mutations for DLG: H51Y and R263K. If You put them together and inject them intentionally the HIV gets so weak that it cant integrate anymore( if I understand it correctly). But its only theoretical so far.

It is only important that it is very unlikely that treatment-naives ever get these mutations. Because of that DLG is recommendable for them.
Have fun with Tivicay :)
Dovato

Offline wolfter

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Re: Tivicay
« Reply #20 on: September 12, 2013, 03:01:27 pm »
My doctor just switched out my Isentress  to Tivicay.  I'm yet again a guinea pig as I'm his first.   ;)  Hoping this cures the extreme insomnia.
Being honest is not wronging others, continuing the dishonesty is.

Offline Cluffmasta

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  • Posts: 22
Re: Tivicay
« Reply #21 on: September 12, 2013, 08:28:28 pm »
Who else is taking the Tivicay, what are you experiencing? It has mostly been great for me, however I have had a lot of constipation since starting it. Let us know how it is working for you!

Offline wolfter

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Re: Tivicay
« Reply #22 on: September 12, 2013, 09:58:05 pm »
I imagine there aren't many here on Vivicay since it was approved less than a month ago.  I can't find relevant information on it.  I should have listened to my doctor more intently.

Not sure why some of us have to take it twice daily and others take it once a day.  Hell, I already forgot what other med I will still be taking with it.  He also said something about personalizing this drug combo?

Damn short term memory. :(
Being honest is not wronging others, continuing the dishonesty is.

Offline GoForIt

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  • Posts: 214
Re: Tivicay
« Reply #23 on: September 13, 2013, 08:40:43 pm »
I imagine there aren't many here on Vivicay since it was approved less than a month ago.  I can't find relevant information on it.  I should have listened to my doctor more intently.

Not sure why some of us have to take it twice daily and others take it once a day.  Hell, I already forgot what other med I will still be taking with it.  He also said something about personalizing this drug combo?

Damn short term memory. :(

just type into Google "Tivicay"...ViiV makes it...but its called Tivicay...
Also you'll find out that some take it twice daily because of higher levels of resistance.

I got prescribed it with epzicom because they will be coming together in 1 pill shortly and 1 pill is easier than 2.  So might as well get used to them both since I will eventually switch to the 1 new pill that has both of them. 

Want to hear from anyone else who is on Tivicay currently though and what their combination is as well as side effects....
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline Miss Philicia

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  • celebrity poster, faker & poser
Re: Tivicay
« Reply #24 on: September 13, 2013, 09:15:05 pm »
There's info about every drug (even things in clinical trials) on this web site -- you don't need to google it.

http://www.aidsmeds.com/archive/Tivicay_2422.shtml
"I’ve slept with enough men to know that I’m not gay"

Offline wolfter

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Re: Tivicay
« Reply #25 on: September 13, 2013, 09:58:30 pm »
I guess I should have specified that I couldn't find a lot of information from individual users in regards to their experiences.

The clinical and technical information is all available within this site without "googling"   ;)
Being honest is not wronging others, continuing the dishonesty is.

Offline GoForIt

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  • Posts: 214
Re: Tivicay
« Reply #26 on: September 16, 2013, 08:17:56 pm »
Picked up my first bottle of Tivicay and Truvada today. 

Found out by gene test that I have the gene that causes the severe allergic reaction to Epzicom so I cannot ever take epzicom.

Still not sure exactly when the best time to take these two meds would be.  At night or in the morning?

I was hoping I could take Epzicom because GSK will be making the Tivicay/Epzicom pill in one early next year and it would be easier then having to fill 2 medications but oh well at least I was able to find out through a test that Epzicom is not for me before ever taking it.

Still very interested to hear from others about how their Tivicay experience is going.

Really hoping that Tivicay doesn't have some underlying severe allergic side effect the way Epzicom did with the heart as they are both made by GSK. 

The clinical trials say nothing but great things but I am still very skeptical as there are not many actual opinions to go by.
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline Schnauzer

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Re: Tivicay
« Reply #27 on: September 24, 2013, 01:09:04 pm »
I got prescribed it with epzicom because they will be coming together in 1 pill shortly and 1 pill is easier than 2.  So might as well get used to them both since I will eventually switch to the 1 new pill that has both of them. 


How shortly?
One good turn gets most of the blankets.

Offline GoForIt

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Re: Tivicay
« Reply #28 on: September 24, 2013, 01:35:14 pm »

How shortly?

The word is early 2014 on that.

On another note I have been taking Truvada & Tivicay for a week now with no noticeable side effects.
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline NycJoe

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Re: Tivicay
« Reply #29 on: September 30, 2013, 06:42:55 pm »
I just got a script for this and very excited to try something other than Atripla for fewer side effects.  I will definitely give everyone an update once I start and see how my numbers go along with any possible side effects.

Joe

Offline Cluffmasta

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Re: Tivicay
« Reply #30 on: October 03, 2013, 07:06:12 pm »
5 weeks now on Tivicay and Truvada, Only noticable side effect that has lingered is a dull headache. I had my labs done last week and Tivicay has kept my VL undetectable still! I am super pleased with this medication!  :)

Offline GoForIt

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Re: Tivicay
« Reply #31 on: October 11, 2013, 03:47:08 pm »
Been on Tivicay and Truvada for 3 weeks now.  Took my labs at 2 weeks and am pleased to say I am Undetectable.  What used to take 3-6 months to be undetectable now only takes 2 weeks.  Pretty cool.  Hope to see a CD4 raise in the coming months.  No side effects from Tivicay and Truvada with me.
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline Cluffmasta

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Re: Tivicay
« Reply #32 on: October 11, 2013, 06:21:30 pm »
Awesome news GoForIt! Glad that it is working well for both of us!  :D

Offline GoForIt

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Re: Tivicay
« Reply #33 on: October 11, 2013, 06:46:16 pm »
Awesome news GoForIt! Glad that it is working well for both of us!  :D

Thanks Cluffmasta! 
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline Valmont

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Re: Tivicay
« Reply #34 on: October 11, 2013, 08:01:26 pm »
Great, Cluff !!! 

And about side effects, does it bother in your normal life?
Apr 2011: Diagnotized
Jun 2011: CD4: 504  VL: 176.000
Dic 2011: CD4: 714  VL: 95.000
May 2012: CD4: 395 VL: 67.000
Jun 2012: CD4: 367
Agu 2012: Starting Emtricitabine 200 mg / Tenofovir 300 mg and Efavirenz 600 mg (2 pills) different brands or VIRADAY/ATRIPLA/Mylan....
Sep 2012: VL: 138
Dic 2012: CD4: 708 VL: <34  %CD4: 32%
Jan 2013: CD4: 707 VL: <20
May 2013: CD4: 945 VL: <34 %CD4: 33%
Agu 2013: CD4: 636 VL: <34 %CD4: 50%
Dic 2013: Latent TB, started Isoniazid

Offline friskyguy

  • Member
  • Posts: 109
Re: Tivicay
« Reply #35 on: October 12, 2013, 01:52:28 pm »
Hi all,

Does anyone know how well this newbie med penetrates into the brain / CSF or can point to some research on this?  any ranking?

From what I have read so far it looks like a safe med but protection from replication in the brain is a high priority and as we know some meds have better penetration than others.

Thanks
Sero converted Sept '10 / Confirmed + Dec '10
Jan '11, VL 9,500 / CD4 482 (32%)
Feb '11, VL 5,800 / CD4 680 (37%)
start Atripla
Mch '11, VL UD / CD4 700 (42%)
Jun  '11, VL UD / CD4 750 (43%)
swap to Kivexa and Efav. due to osteopenia diag. (DEXA) / kidney issues ( decline in eGFR to 77 )
start supplements - Vit D3 / Omega 3 / multivitamin / mini aspirin
Dec '11,  VL UD <20 /  CD4 670 (49%)  / CD4:CD8 = 1.4
all labs now within normal ranges
Mch '12,  VL UD / CD4 600 (51%)
Sep '12,  VL UD / CD4 810 (51%)
Mch '13   VL UD / CD4 965 (56%)
Sep '13   VL UD / CD4 (not taken)
Dec '13   VL UD / CD4 901 (35%) / CD4:CD8 = 1.1  /  eGFR > 100

Offline Cluffmasta

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  • Posts: 22
Re: Tivicay
« Reply #36 on: October 15, 2013, 11:57:14 am »
Hey Valmont, the headache does not bother me during the day! It seemed to be worse the first week starting the Tivicay but has since gone away to almost nothing at all!

Offline Valmont

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  • Posts: 338
Re: Tivicay
« Reply #37 on: October 15, 2013, 07:52:47 pm »
That is great, thanks for your answer...  I hope you the best with this medecine, it seems very interesting to me...
Apr 2011: Diagnotized
Jun 2011: CD4: 504  VL: 176.000
Dic 2011: CD4: 714  VL: 95.000
May 2012: CD4: 395 VL: 67.000
Jun 2012: CD4: 367
Agu 2012: Starting Emtricitabine 200 mg / Tenofovir 300 mg and Efavirenz 600 mg (2 pills) different brands or VIRADAY/ATRIPLA/Mylan....
Sep 2012: VL: 138
Dic 2012: CD4: 708 VL: <34  %CD4: 32%
Jan 2013: CD4: 707 VL: <20
May 2013: CD4: 945 VL: <34 %CD4: 33%
Agu 2013: CD4: 636 VL: <34 %CD4: 50%
Dic 2013: Latent TB, started Isoniazid

Offline eric48

  • Standard
  • Member
  • Posts: 1,361
Re: Tivicay
« Reply #38 on: October 18, 2013, 05:45:14 pm »
...it seems very interesting to me...

Here too... I'm dying of ... jealousy

Hoping everyone will be happy with it and looking forward t have it approved AND covered, here as well

Eric
NVP/ABC/3TC/... UD ; CD4 > 900; CD4/CD8 ~ 1.5   stock : 6 months (2013: FOTO= 5d. ON 2d. OFF ; 2014: Clin. Trial NCT02157311 = 4days ON, 3days OFF ; 2015: https://clinicaltrials.gov/ct2/show/NCT02157311 ; 2016: use of granted patent US9101633, 3 days ON, 4days OFF; 2017: added TDF, so NVP/TDF/ABC/3TC, once weekly

Offline wolfter

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  • Posts: 5,470
Re: Tivicay
« Reply #39 on: November 14, 2013, 12:00:00 pm »
Curious how you all are doing on this drug.  I'm getting my script to switch out the Isentress to Tivicay for sleep issues. 

Wolfie
Being honest is not wronging others, continuing the dishonesty is.

Offline Miss Philicia

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  • Posts: 24,793
  • celebrity poster, faker & poser
Re: Tivicay
« Reply #40 on: November 14, 2013, 01:55:49 pm »
Curious how you all are doing on this drug.  I'm getting my script to switch out the Isentress to Tivicay for sleep issues. 

Wolfie

Just so you know, difficulty sleeping/insomnia is also a possibility with Tivicay though I don't know what the % comparison is with their respective clinical trials, and of course Tivicay will have less information about this because not many patients are on it.

And, of course, difficulty sleeping/insomnia could ultimately be just general and exist regardless of these two medications. Anyway, good luck.
"I’ve slept with enough men to know that I’m not gay"

Offline GoForIt

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  • Posts: 214
Re: Tivicay
« Reply #41 on: November 14, 2013, 02:39:15 pm »
I've been on it for 2 months now and I feel blessed that I have no side-effects.  Going to get new labs done after 3 months.  It worked fast to bring VL down to UD in 2 weeks from being treatment naive.  They say headache and insomnia were reported in trials but I have not experienced either.  I take mine around 10pm and usually fall asleep between 10-12pm each night...usually earlier rather than later so no insomnia here.  I feel very lucky I was able to skip over Atripla which was so recommended the past 7 years or so which has CNS issues and sleep issues.  Tivicay is a great medicine in terms of low side-effect profile and its effectiveness.
« Last Edit: November 14, 2013, 02:44:18 pm by GoForIt »
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline Cluffmasta

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Re: Tivicay
« Reply #42 on: November 15, 2013, 12:12:34 pm »
Hey Wolfter! I switched out the Isentress for the Tivicay in August and it has been the best decision I have made in my treatment regimen the past 5 years! No Side effects other than a slight headache here and there. I too like GoForIt take it with Truvada around 10pm or 11pm and sleep just fine. The Isentress gave me terrible headaches and diarrhea and have had none of that while on the Tivicay. Just had second round of labs done and it has kept my VL undetectable and boosted my CD4 a little as well! Excited to hear how you do on it too! Keep us posted!

Offline wolfter

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Re: Tivicay
« Reply #43 on: November 15, 2013, 12:30:26 pm »
I've created quite a list for doctor when I see him this coming Thursday.  (I got ready yesterday before I realized I had the wrong week)  He indicated I'll have to take it twice a day.  I'm finding little information on the Web.  I'll take it along with my Truvada and Intellence. 

My biggest concern is if I should have issues with the change, can I go back to my existing combo.  I'd hate to trade out insomnia for something worse.   :o
Being honest is not wronging others, continuing the dishonesty is.

Offline Cluffmasta

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Re: Tivicay
« Reply #44 on: November 15, 2013, 01:41:33 pm »
When I switched in August I had the same concern about being able to switch back if I did not like any new side effects.. My Dr. told me there was no issue and that I could switch back to taking the Isentress and Truvada. Hopefully you will have the same outcome as I have with no side effects at all with the Tivicay!

Offline Miss Philicia

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  • celebrity poster, faker & poser
Re: Tivicay
« Reply #45 on: November 15, 2013, 02:25:15 pm »
Of course you can switch back. Changing medication regimens doesn't cause resistance, unless you had developed resistance before the change.
"I’ve slept with enough men to know that I’m not gay"

Offline oksikoko

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  • Writing the congressman again
Re: Tivicay
« Reply #46 on: November 15, 2013, 03:55:54 pm »
I've created quite a list for doctor when I see him this coming Thursday.  (I got ready yesterday before I realized I had the wrong week)  He indicated I'll have to take it twice a day.  I'm finding little information on the Web.  I'll take it along with my Truvada and Intellence. 

The only thing I've seen regarding once vs. twice dosing is this:

"If efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin are coadministered, then the dose is TIVICAY 50 mg twice daily."

-or-

"INSTI-experienced with certain INSTI-associated resistance substitutions or clinically suspected INSTI resistance."

Maybe he suspects you have integrase inhibitor resistance?
Code: [Select]
2014-11-14: CD4 Wars Episode II: Return of the Stribild (released in Europe as Stribild II: Werewolf Bitch)
2014-11-06:                ☣ VL (→) 12,627      ☣ CD4 (→) 639
2014-??-??: off treatment  ☣ VL (?)              ☣ CD4 (?)
2013-10-03:                ☣ VL (=) undetectable ☣ CD4 (+) 1105
2013-05-23:                ☣ VL (=) undetectable ☣ CD4 (-) 945
2013-02-25:                ☣ VL (-) undetectable ☣ CD4 (+) 1123
2012-12-16: Enter Stribild
2012-11-20: HIV+           ☣ VL (→) 132,683      ☣ CD4 (→) 920
2012-04-01: HIV-
Dates in this signature file conform to ISO 8601. ;-)

If no one complains, nothing will ever change.

Offline wolfter

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Re: Tivicay
« Reply #47 on: November 15, 2013, 10:03:51 pm »
The only thing I've seen regarding once vs. twice dosing is this:

"If efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin are coadministered, then the dose is TIVICAY 50 mg twice daily."

-or-

"INSTI-experienced with certain INSTI-associated resistance substitutions or clinically suspected INSTI resistance."

Maybe he suspects you have integrase inhibitor resistance?

My resistance profile if full.  :) 
Of course you can switch back. Changing medication regimens doesn't cause resistance, unless you had developed resistance before the change.

I just worry.  I've developed resistance twice to different combos even with being adherent.  Never did get a probable reason from my previous idiot doctor.
Being honest is not wronging others, continuing the dishonesty is.

Offline uncertain

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  • Trying to find my way
Re: Tivicay
« Reply #48 on: November 18, 2013, 06:51:21 am »
I was diagnosed sero converted and put on isentress truvada prezista norvir in September, the headaches and muscle aches seem to have come after about 7 weeks, not sure which of the meds, but would the docs want to keep me on them for 3 months.  Does Tivocay give less headaches than Isentress.  My Isentress headaches are mild, but I nees asprin.
The candle that burns twice as bright burns half as long....

Offline Cluffmasta

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  • Posts: 22
Re: Tivicay
« Reply #49 on: November 18, 2013, 10:26:31 pm »
Hey uncertain! One of the reasons I switched from Isentress to Tivicay was because of all the headaches I was getting from the Isentress! I was having to take ibuprofen everyday. The first week or two on Tivicay I had some head pressure but nothing like on Isentress! No more daily headaches now. I love what it has done for me and I no longer have to take ibuprofen everyday, which in return has been much more pleasant on my stomach. Been on Tivicay for about 3 months now :)

 


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