High Creatinine after changing medication

[ilovemonday]

Hi all,

I am writing here to share my nervouseness due tonmy latest lab result.
So, i have been on medication TLE for 7 years and my test result was fine. Recently, after moving to Thai, due to the unavailbilitu of TLE, I changed my medication to TLD. However, in the two months, my creatinine level is rising beyond the range. It freaked me out. I thought it was due to the protein supplement I took (i started working out). Then, i decide to stop the supplement and take another test after two weeks. The result is unfortunately remaining high. How should I do with this condition guys? My doctor says to keep my medication or change to another regimen. It stressed me out. 

[Jim Allen]

What exactly do you mean by high? Any specifics?

You only just switched and then stopped the protein powder two weeks ago. Switching can get some labs out of wack, not to mention the supplements, and if it were me, I would give it another couple of weeks to settle back without the supplements and then retest before making any decisions.

If you do end up switching HIV meds again, do you know what options are available or what you want?

[ilovemonday]

Hi Jim, thanks for response.

What I mean high is above the normal level which is 1.2 mg/dL. While mine is 1.4 mg/dL. Before taking my current med, I was fine with 1.1 mg/dL.

I am trying to meet specialist to consult abt my condition. Actually I don't want to change regimen again as I am afraid it will affect in reseitance or something.
I was fine in TLE but in the country I am living now, TLE is mostly discontinued and the doctor I had consult with changed the regimen to TLD (tenofovir, lamivudine, and Dolutegravir)

[harleymc]

We are not doctors, any advice from us is useless.

Talk to your doctor.

[Loa111]

My  creatinine levels increased too. I had a good discussion with ID Doc & pharmacist about it.  I was taking creatine & protein powder etc too. I would go off it about 7- 10 days before getting bloods done at my ID appoint which is every 4 months. So that's 3 1/2 months of supplements before.

My levels were still up. So the doc & pharma advised to go off the creatine for a week or two  longer before next appointment for bloods (so 2 - 4 weeks off). I complied with this, and my levels went back down.

Also they know I take creatine & protein powder ongoing & have noted it. They are not a big fan of people taking supplements as it can throw readings off.

My next appointment is mid-October and I am off supplements a couple of weeks alredy to prepare whcih will give me over 1 month clear. I'll go back on creatine & protein mix the day after my appointment for another 3 months.

[Jim Allen]

Hi Jim, thanks for response.

What I mean high is above the normal level which is 1.2 mg/dL. While mine is 1.4 mg/dL. Before taking my current med, I was fine with 1.1 mg/dL.

I am trying to meet specialist to consult abt my condition. Actually I don't want to change regimen again as I am afraid it will affect in reseitance or something.
I was fine in TLE but in the country I am living now, TLE is mostly discontinued and the doctor I had consult with changed the regimen to TLD (tenofovir, lamivudine, and Dolutegravir)

1.1 to 1.4

With these results I wouldn't stress too much.

I would retest in another few weeks time, if possible , stay off any supplements and see what the results are at that time and what the doctor says.

[Jim Allen]

Actually I don't want to change regimen again as I am afraid it will affect in reseitance or something

.

If the viral load remained supressed and your not switching every few days this realistically shouldn't be a concern. I'm sure your doctor can provide the same reassurance should you need to switch again.

Keep us posted but try not to stress about it

[leatherman]

If the viral load remained supressed and your not switching every few days this realistically shouldn't be a concern.

resistance to a medication happens when a medication is taken haphazardly. Skipping doses every few days allows the levels of meds in your system to dip below the level to adequately disrupt the lifecycle of HIV. HIV can then develop a resistance to a medication.

If you are undetectable and change to another regimen, levels of medications will remain high enough to continue damaging HIV and resistance to the previous medication doesn't have time to occur.

[Tonny2]

           ojo.            Hello there!!!…you always have to talk to your doctor about anything you put in your mouth, no pun intended…either a new med or over the counter meds, even supplements. According to my ID doctor, that kind of protein is bad for people hiv negative let alone for people like us that take medications who are bad for our kidneys so watch out!!!…hoping your level get to normal…as your doctor about whey protein…hugs

[ilovemonday]

Hi guys,
i visited a few doctors including kidney specialist in few weeks ago and here my update.

- my kidney is in normal condition, I did some blood test, urine, and usg. Creatinine still high  nephrologyst just recommend to drink more water.
- based on the internal medicine doctor, this high creatinine is due to the dolutegravir. In some cases, dolutegravir tends to play with the kidney test result giving false high crratinine. This is as dolutegravir may inhibit the secretion of cr. No actual failure on the kidney and he suggest to continue my medication.

[Jim Allen]

Glad to hear its fine.

How are you otherwise doing/feeling?

[ilovemonday]

hi all,

I just want to update related to my condition. 3 months ago, my doctor suggest me to do a "research" by changing my medication back to efavirens and check the creatinine level after two months. Last week, i got the result and mu creatinine finally back to normal 1.1 from 1.4. We conclude that the rising of my creatinine is confirmed due to dolutegravir which gives false positive