POZ Community Forums
Main Forums => Living With HIV => Topic started by: smiteler on November 23, 2010, 09:16:43 pm
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my doctor has told me i'm very close to being diabetic :o
now i know why :'(
http://www.msnbc.msn.com/id/40345008/ns/health-aids/ (http://www.msnbc.msn.com/id/40345008/ns/health-aids/)
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Protease inhibitors were the culprits? That seems like the sorta thing that a college junior majoring in Health Sciences could've figured out in a statistics class. Did we really not know they were correllated with higher insulin resistance before?
"Now that we've identified the main mechanism, we will look to develop new drugs that treat HIV but don't cause diabetes."
Unless they're talking about a mechanism of PIs which occurs with other drugs, and not PIs themselves, this all seems redundant.
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I was diagnosed with diabetes about 12 or 13 years ago. While I don't like it at all, it's not the end of the world. Just something else to deal with.
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When attempting to allay my fears about being newly Positive my doctor said "I deal with a lot of hiv+ patients as well as patients who have diabetes and if I had to pick between the two I would pick hiv." That bastard didn't tell me one was causative of the other!
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That bastard didn't tell me one was causative of the other!
Did you even read the article? It does NOT say that hiv causes diabetes (and diabetes certainly doesn't cause hiv).
From the article...
The culprit lies in the powerful drugs that prevent the development of AIDS and have extended the lives of many HIV patients, the researchers say. They hope the discovery will allow development of safer antiviral drugs.
The research, published this month in the Journal of Biological Chemistry, shows HIV protease inhibitor drugs directly interfere with the way blood sugar levels are controlled in the body. This leads to insulin resistance, a condition that occurs when the body produces enough insulin but doesn't use it properly.
(emphasis mine so Hell didn't miss the salient points again)
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I avoid sugar, but artificial sweeteners aren't too healthy either. :-\
It has to do with the liver enzymes:
1. normal people can eat grapefruit, grapefruit inhibits the releasing of insulin
2. people who take PI's or cholesterol lowering drugs mustn't eat grapefruit (or drink its juice)
because the side effects of the drugs are much severe with grapefruit
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The article mentions "first-generation protease inhibitors" and also mentions ritonavir; it would help if they were more specific about which PIs they found to have a link. It seems it may not be all of them.
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my doctor has harped on me a few times about what i eat
and asking about my family history because my levels are boarderline diabetic.
the only thing i add sugar to is my coffee,i don't drink sodas
or eat sweets and it doesn't run in my family.
so it was perplexing to me until
i read this article.
now i have ammo to show my doctor its not me.
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Eating too much sugar isn't going to lead to the development of diabetes. When one talks about insulin regulating blood sugar, it is talking about glucose. Just about anything you eat will eventually be turned into glucose, because this is what fuels your cells.
Mike
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Here's the abstract, first published in Sept, then republished in Nov:
http://www.jbc.org/content/285/47/36395.abstract
I could not find any abstract in humans.
v
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Hruz said that about 25 percent of HIV patients develop diabetes.
This is pure speculation, given the low dose of ritonavir most people on PIs take
- matt
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Did you even read the article? It does NOT say that hiv causes diabetes (and diabetes certainly doesn't cause hiv).
From the article...
The culprit lies in the powerful drugs that prevent the development of AIDS and have extended the lives of many HIV patients, the researchers say. They hope the discovery will allow development of safer antiviral drugs.
The research, published this month in the Journal of Biological Chemistry, shows HIV protease inhibitor drugs directly interfere with the way blood sugar levels are controlled in the body. This leads to insulin resistance, a condition that occurs when the body produces enough insulin but doesn't use it properly.
(emphasis mine so Hell didn't miss the salient points again)
I know what it said. Should I boldface some words for you to read? I was trying to be jocular it obviously sailed right over your head. All apologies for confusing you.
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Should I boldface some words for you to read? I was trying to be jocular it obviously sailed right over your head.
I keep on telling you people to use those emoticons :D ;D
:-* HR :-* Ann
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So if your not a pi then this is less of an issue?
I'm on truvada/selzentry
I don't think there pi's right?
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So if your not a pi then this is less of an issue?
I'm on truvada/selzentry
I don't think there pi's right?
You're right, they're not PIs: Truvada is an NtRTI + an NRTI, and Selzentry is an entry inhibitor.
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thank you!
so i guess my question would be why do dr's still prescribe the PI? I hear there bad to on all the lipo issues too. maybe i heard wrong.
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thank you!
so i guess my question would be why do dr's still prescribe the PI? I hear there bad to on all the lipo issues too. maybe i heard wrong.
Docs still prescribe PIs because people need them! Yes there are lipo issues but a positive diabetic is better than a dead PI-phobe.
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So if your not a pi then this is less of an issue?
....
I don't think there pi's right?
by the way, AM has a lovely list of all the available meds at http://www.aidsmeds.com/list.shtml. click on a med and learn all about it.
and PIs are prescribed many times because they can be an excellent booster, enhancing the effectiveness of the other meds in a regimen, therefore requiring a smaller dosage and/or gaining more bang for the buck.
IF you read the package insert on all of these meds you will learn that for nearly all meds, the majority of those in the original study had NO side effects. (issues like diabetes are simply another side effect) Side effects usually happen to well under 25% of the population else drugs companies would probably not even market these meds. Of course a higher percentage may have some side effects (nausea, vomiting, gas, etc) while getting adjusted to the meds (adjusting to the levels of these chemicals in the body, along with the bodily change in the immune system as the HIV viral load is reduced); but only a few percentage deal with side effects longer than a couple of months.
of course, your mileage may vary according to the drug you are taking and your body, but clearly the facts from the clinical trials show these meds working adequately and without long term side effects for most people who take them.