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Author Topic: Improved CAR T therapy controls HIV, human testing planned next spring  (Read 2852 times)

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Offline gorka

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This is an exciting development given that early trials failed.  Wondering what sites will be participating in human trials

http://www.sandiegouniontribune.com/business/biotech/sd-me-immune-hiv-20171012-story.html

Offline Ptrk3

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Re: Improved CAR T therapy controls HIV, human testing planned next spring
« Reply #1 on: October 15, 2017, 04:27:35 pm »
Here's another news article on the same story, this one from the October 12, 2017, edition of Science Daily (HIV and AIDS):

https://www.sciencedaily.com/releases/2017/10/171012143131.htm

From the story:

"Improving on a previous attempt, scientists have developed a new strategy that could potentially be used to reengineer a patient's own immune system cells to fight HIV. The approach, described in PLOS Pathogens, shows benefit in human cell cultures and in mice...

...The new technique builds on the earlier approach that made it to clinical trials, which relied on a chimeric antigen receptor (CAR) -- a synthetic protein that when added to T cells allows them to fight a specific foe more effectively. In treatment, T cells extracted from a patient's blood would be reengineered in the lab to express HIV-specific CARs, and then infused back into the patient to fight the virus. (Other CAR-based techniques successfully enhance T cell attack of some cancer cells.)..."
HIV 101 - Basics
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You can read more about PEP and PrEP here
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