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Author Topic: Engineered B cells in Mice produce broadly neutralizing anti-HIV antibodies  (Read 1325 times)

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Offline Jim Allen

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Early days and we know most of these things don't pan out but an interesting read, although, the media hype around this one is the usual nonsense::)

A study by Dr. Adi Barzel and PhD student Alessio Nehmad used CRISPR gene-editing genetically engineered type B white blood cells (with one coding for Staphylococcus aureus Cas9 (saCas9) and the other for 3BNC117, an anti-HIV bNAb) to produce neutralizing antibodies against HIV in mice and lab dishes.

Abstract:
https://www.nature.com/articles/s41587-022-01328-9

https://www.genengnews.com/virology/hiv/could-a-one-shot-treatment-for-patients-with-hiv-be-on-the-horizon/

In Full: Thanks to genengnews.com.

https://www.nature.com/articles/s41587-022-01328-9.epdf?sharing_token=zmq5yP07hfwhLuRf-WoU79RgN0jAjWel9jnR3ZoTv0O4VgULSyAEQr4OdsIEhFjnxDnQfSzX7Dbd5lWp5IQgafD3BGY2LPeXH_HBB43jKhs2Ml-H4Z6XzKi0bwhZjpaZHpOCw1eNw3_KfL1dwKLXLUiaJwuyiMDnr7B5QTWc2Lhdb2AB_LmvopFeYW2nFclDR5pB_p1g3Wzk1Gou6ZtRmZUVOeTJ5q1r8VxDGrDQ5-M%3D&tracking_referrer=www.genengnews.com

Another study using an anti-HIV-1 antibody for viral suppression was also recently posted:


Viral suppression with anti-HIV-1 antibody - Phase 1b 3BNC117 & 10-1074
https://forums.poz.com/index.php?topic=76091.msg
« Last Edit: June 15, 2022, 11:05:57 am by Jim Allen »
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Offline jeju

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Quote
Researchers at Tel Aviv University have developed a new and unique treatment method that could possibly be developed into a vaccine or a one-time treatment for HIV/AIDS. The new technique utilizes type B white blood cells that would be genetically engineered inside the patient's body to secrete anti-HIV antibodies in response to the virus.

https://www.thehealthsite.com/news/one-time-treatment-for-hiv-aids-a-single-injection-is-all-that-you-may-need-887252/
« Last Edit: June 15, 2022, 11:30:02 am by Jim Allen »
If I'm not dead there's a reason

Offline Da2020

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Canít agree more with media nonsense. They havenít even tested it in vivo

 


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